SNR and functional sensitivity of BOLD and perfusion-based fMRI using arterial spin labeling with spiral SENSE at 3 T

Perthen, Joanna E.; Bydder, Mark; Restom, Khaled; Liu, Thomas T.

doi:10.1016/j.mri.2007.10.008

Cited by 30 publications

(29 citation statements)

References 24 publications

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“…Based on previous imaging parameters (Ances et al 2010; Perthen et al 2008a, b; Restom et al 2008), CBF measurements were obtained by arterial spin labeling (ASL). Four axial slices, that included the LN, were acquired in a linear fashion from bottom to top.…”

Section: Methodsmentioning

confidence: 99%

HIV and Chronic Methamphetamine Dependence Affect Cerebral Blood Flow

Ances

Vaida

Cherner

et al. 2011

J Neuroimmune Pharmacol

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Human immunodeficiency virus (HIV) and methamphetamine (METH) dependence are independently associated with neuronal dysfunction. The coupling between cerebral blood flow (CBF) and neuronal activity is the basis of many task-based functional neuroimaging techniques. We examined the interaction between HIV infection and a previous history of METH dependence on CBF within the lenticular nuclei (LN). Twenty-four HIV−/METH−, eight HIV−/METH+, 24 HIV+/METH−, and 15 HIV+/METH+ participants performed a finger tapping paradigm. A multiple regression analysis of covariance assessed associations and two-way interactions between CBF and HIV serostatus and/or previous history of METH dependence. HIV+ individuals had a trend towards a lower baseline CBF (−10%, p=0.07) and greater CBF changes for the functional task (+32%, p=0.01) than HIV− subjects. Individuals with a previous history of METH dependence had a lower baseline CBF (–16%, p= 0.007) and greater CBF changes for a functional task (+33%, p=0.02). However, no interaction existed between HIV serostatus and previous history of METH dependence for either baseline CBF (p=0.53) or CBF changes for a functional task (p=0.10). In addition, CBF and volume in the LN were not correlated. A possible additive relationship could exist between HIV infection and a history of METH dependence on CBF with a previous history of METH dependence having a larger contribution. Abnormalities in CBF could serve as a surrogate measure for assessing the chronic effects of HIV and previous METH dependence on brain function.

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Section: Methodsmentioning

confidence: 99%

HIV and Chronic Methamphetamine Dependence Affect Cerebral Blood Flow

Ances

Vaida

Cherner

et al. 2011

J Neuroimmune Pharmacol

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“…This reduction in SNR may in part undermine the accuracy of quantitative CBF estimates. Moreover, the SNR disadvantage may lead to reduced sensitivity for neuronal events (Perthen et al, 2008), and may potentially have led to the lower reliability scores in CBF-based functional connectivity measurements (Jann et al, 2015a;Viviani et al, 2011). This may be exacerbated by ASL's need for longer TRs compared to techniques such as slice-accelerated BOLD , limiting the statistical power of CBF-based FC for a given acquisition duration.…”

Section: Perfusion-based Functional Connectivity Mappingmentioning

confidence: 99%

Characterizing Resting-State Brain Function Using Arterial Spin Labeling

2015

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Arterial spin labeling (ASL) is an increasingly established magnetic resonance imaging (MRI) technique that is finding broader applications in studying the healthy and diseased brain. This review addresses the use of ASL to assess brain function in the resting state. Following a brief technical description, we discuss the use of ASL in the following main categories: (1) resting-state functional connectivity (FC) measurement: the use of ASL-based cerebral blood flow (CBF) measurements as an alternative to the blood oxygen level-dependent (BOLD) technique to assess resting-state FC; (2) the link between network CBF and FC measurements: the use of network CBF as a surrogate of the metabolic activity within corresponding networks; and (3) the study of resting-state dynamic CBF-BOLD coupling and cerebral metabolism: the use of dynamic CBF information obtained using ASL to assess dynamic CBF-BOLD coupling and oxidative metabolism in the resting state. In addition, we summarize some future challenges and interesting research directions for ASL, including slice-accelerated (multiband) imaging as well as the effects of motion and other physiological confounds on perfusion-based FC measurement. In summary, this work reviews the state-of-the-art of ASL and establishes it as an increasingly viable MRI technique with high translational value in studying resting-state brain function.

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“…Such background modulation, if not properly accounted for, can substantially confound flow quantification via the location the subject's head is placed in the coil. A few ASL studies have incorporated correction of coil sensitivity in the post-processing (Perthen et al, 2008).…”

Section: Introductionmentioning

confidence: 99%