Social Behaviour Risk Factors for Drug Resistant Tuberculosis in Mainland China: A Meta-Analysis

Zhao, Pei; Xj, Li; Sf, Zhang; Xs, Wang; Liu, CY

doi:10.1177/147323001204000205

Cited by 57 publications

(57 citation statements)

References 14 publications

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“…A similar report also came from mainland China (8). The 2002–2007 global survey conducted by WHO also showed that the highest prevalence of MDR-TB among newly diagnosed and previously treated TB cases was 22% and 60%, respectively (5).…”

Section: Discussionsupporting

confidence: 53%

“…The consistent findings across decades in the majority of studies and in this meta-analysis probably indicate how much the Mycobacterium TB is predisposed to develop resistance when it is exposed to anti-TB drugs. This may be related to poor patient's adherence to treatment schedule, as previous reports showed (8). …”

Section: Discussionmentioning

confidence: 86%

“…Several of the studies compared the resistance of new TB and previously TB treated cases without further stratifying the initial treatment pattern by duration, adherence to anti-TB drugs, and defaulting from taking drugs, which were attributed as important risk factors for occurrence of resistance (7, 8). …”

Section: Discussionmentioning

confidence: 99%

“…Resistant TB strains can be acquired or new resistant TB strains can emerge due to different factors: previous use of quinolones (6), inappropriate TB treatment (7), poor adherence to anti-TB drugs, long-lasting illnesses, previous TB treatment (8, 9). Very recently, WHO concluded that people living with HIV are facing the emerging threats of drug resistant TB (4), which was also noted in another report (10).…”

Section: Introductionmentioning

confidence: 99%

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A meta-analysis of Drug resistant Tuberculosis in Sub-Saharan Africa: How Strongly Associated with previous Treatment and HIV Co-infection?

Berhan¹,

Berhan²,

Yizengaw³

2013

Ethiop J Health Sci

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BackgroundIn Sub-Saharan Africa, the fight against tuberculosis (TB) has encountered a great challenge because of the emergence of drug resistant TB strains and the high prevalence of HIV infection. The aim of this meta-analysis was to determine the association of drug-resistant TB with anti-TB drug treatment history and HIV co-infection.MethodsAfter electronic based literature search in the databases of Medline, HINARI, EMBASE and the Cochrane library, article selection and data extraction were carried out. HIV co-infection and previous history of TB treatment were used as predictors for the occurrence of any anti-TB drug resistant or multiple drug resistant TB (MDR-TB). The risk ratios for each included study and for the pooled sample were computed using the random-effects model. Heterogeneity test, sensitivity analyses and funnel plots were also done.ResultsThe pooled analysis showed that the risk of developing drug-resistant TB to at least one anti-TB drug was about 3 times higher in individuals who had a previous history of anti-TB treatment than new TB cases. The risk of having MDR-TB in previously anti-TB treated TB cases was more than 5-fold higher than that of new TB cases. Resistance to Ethambutol and Rifampicin was more than fivefold higher among the previously treated with anti-TB drugs. However, HIV infection was not associated with drug-resistant TB.ConclusionThere was a strong association of previous anti-TB treatment with MDR-TB. Primary treatment warrants special emphasis, and screening for anti-TB drugs sensitivity has to be strengthened.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A meta-analysis of Drug resistant Tuberculosis in Sub-Saharan Africa: How Strongly Associated with previous Treatment and HIV Co-infection?

Berhan¹,

Berhan²,

Yizengaw³

2013

Ethiop J Health Sci

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“…Previous treatment has repeatedly been reported as the key factor contributing to the risk of MDR and XDRTB [30,31]. In the current study TB therapy in the past was the most significant risk factor for acquiring drug resistance with each additional treatment episode doubling the risk of MDR development.…”

Section: Discussionmentioning

confidence: 54%

Resistance profile and risk factors of drug resistant tuberculosis in the Baltic countries

et al. 2015

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Risk factors for multidrug resistance among previously treated patients with tuberculosis in eastern China: a case–control study

Chen

Huai

Zhong

et al. 2013

International Journal of Infectious Diseases

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Social Behaviour Risk Factors for Drug Resistant Tuberculosis in Mainland China: A Meta-Analysis

Abstract: Previous treatment, poor quality DOTS, poor treatment adherence, long term illness, age 40 - 60 years and poverty are associated with a greater risk of drug resistant TB in mainland China.

Cited by 57 publications

References 14 publications

A meta-analysis of Drug resistant Tuberculosis in Sub-Saharan Africa: How Strongly Associated with previous Treatment and HIV Co-infection?

A meta-analysis of Drug resistant Tuberculosis in Sub-Saharan Africa: How Strongly Associated with previous Treatment and HIV Co-infection?

Resistance profile and risk factors of drug resistant tuberculosis in the Baltic countries

Risk factors for multidrug resistance among previously treated patients with tuberculosis in eastern China: a case–control study

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