Social bonding: regulation by neuropeptides

Lieberwirth, Claudia; Wang, Zuoxin

doi:10.3389/fnins.2014.00171

Cited by 70 publications

(53 citation statements)

References 187 publications

(288 reference statements)

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“…This point is somewhat contradictory to much of the literature in this regard [54]. One possible explanation to this finding is that the subjects in our study had severe form of conduct problems, wherein the presence of CU traits are relatively common.…”

Section: Discussioncontrasting

confidence: 55%

Salivary oxytocin in adolescents with conduct problems and callous-unemotional traits

Levy

Bloch

Bar-Maisels

et al. 2015

Eur Child Adolesc Psychiatry

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Callous-unemotional (CU) traits correlate with the severity and prognosis of conduct disorder in youth. The neuropeptide oxytocin (OT) has been linked to prosocial behaviors, including empathy and collaboration with others. This study discusses a possible role for OT in the biology of delinquent behavior. We hypothesized that in delinquent youth OT secretion will correlate with the severity of conduct problems and specifically with the level of CU traits. The study group included 67 male adolescents (mean age 16.2 years) undergoing residential treatment, previously assessed by an open clinical interview and history for the psychiatric diagnosis. Staff based Inventory of Callous-Unemotional traits for psychopathy and Strength and Difficulties Questionnaire were administered, and patients' medical and social personal files were systematically coded for previous history of antisocial acts using the Brown-Goodwin Questionnaire. Salivary OT was assayed by ELISA. Salivary OT levels were inversely correlated with conduct problems severity on Strength and Difficulties Questionnaire (r = -0.27; p ≤ 0.01). Recorded history of antisocial acts did not correlate with current OT levels. Odds ratio (OR) for significant CU traits among subjects with conduct problems was increased in low-OT (OR = 14, p ≤ 0.05) but not in high-OT subjects (OR = 6, p ≥ 0.05). Children with conduct problems and low levels of salivary OT are at risk for significant CU traits. These results suggest a possible role for salivary OT as a biomarker for CU traits and conduct problems severity.

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Section: Discussioncontrasting

confidence: 55%

Salivary oxytocin in adolescents with conduct problems and callous-unemotional traits

Levy

Bloch

Bar-Maisels

et al. 2015

Eur Child Adolesc Psychiatry

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“…OT and AVP modulate bonding behavior in diverse lineages [17]. Blockade of OTR and AVPR1a homologs in monogamous cichlid fishes reduces affiliative behavior during bond formation [18], and exogenous OT delivery promotes affiliative behavior toward conspecific and human partners in dogs [19].…”

Section: Social Neuropeptides In Pair Bondingmentioning

confidence: 99%

Neurobiological mechanisms of social attachment and pair bonding

Johnson

Young

2015

Current Opinion in Behavioral Sciences

154

138

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Species have evolved diverse social behavior and mating strategies in response to selective forces in their environments. While promiscuity is the predominant mating strategy across most vertebrate taxa, convergent evolution of monogamous mating systems has occurred multiple times across distant lineages. Monogamous behavior is thought to be facilitated by a neurobiological capacity to form and maintain selective social attachments, or pair bonds, with a mating partner. The neural mechanisms of pair bonding behavior have been investigated most rigorously in Microtine rodents, which exhibit diverse social organizations. These studies have highlighted mesolimbic dopamine pathways, social neuropeptides (oxytocin and vasopressin), and other neural systems as integral factors in the formation, maintenance, and expression of pair bonds.

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“…Nonapeptides (the mammalian peptides OT and vasopressin) modulate socially relevant mechanisms of behavior and physiology by influencing sensory processing, integrating sensorimotor information, assigning valence to stimuli and influencing the context-dependent coupling of relevant brain areas [Goodson and Thompson, 2010]. Nonapeptides are important modulators of affiliation [Lieberwirth and Wang, 2014] and, in birds, group size [Goodson et al, 2009]. VIP is perhaps best known as a prolactin-releasing factor in birds [El Halawani et al, 1997] and mammals [Kato et al, 1978], but VIP fibers and receptors are widely distributed throughout socially relevant brain areas, and recent work highlights VIP's role in modulating grouping, affiliation, pair-bonding, aggression and seasonal rhythms [for a review, see Kingsbury, 2015].…”

mentioning

confidence: 99%

Seasonal Variation in Group Size Is Related to Seasonal Variation in Neuropeptide Receptor Density

Wilson

Goodson

Kingsbury³

2016

Brain Behav Evol

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In many species, seasonal variation in grouping behavior is widespread, with shifts towards territoriality in the breeding season and grouping in the winter. Compared to the hormonal and neural mechanisms of seasonal territorial aggression, the mechanisms that promote seasonal grouping have received little attention. We collected brains in spring and winter from wild-caught males of two species of emberizid sparrows that seasonally flock (the field sparrow, Spizella pusilla, and the dark-eyed junco, Junco hyemalis) and two species that do not seasonally flock (the song sparrow, Melospiza melodia, and the eastern towhee, Pipilo erythrophthalmus). We used receptor autoradiography to quantify seasonal plasticity in available binding sites for three neuropeptides known to influence social behavior. We examined binding sites for ¹²⁵I-vasoactive intestinal polypeptide (VIP), ¹²⁵I-sauvagine (SG, a ligand for corticotropin-releasing hormone receptors) and ¹²⁵I-ornithine vasotocin analog (OVTA, a ligand for the VT3 nonapeptide). For all species and ligands, brain areas that exhibited a seasonal pattern in binding density were characterized by a winter increase. Compared to nonflocking species, seasonally flocking species showed different binding patterns in multiple brain areas. Furthermore, we found that winter flocking was associated with elevated winter ¹²⁵I-VIP binding density in the medial amygdala, as well as ¹²⁵I-VIP and ¹²⁵I-OVTA binding density in the rostral arcopallium. While the functional significance of the avian rostral arcopallium is unclear, it may incorporate parts of the pallial amygdala. Our results point to this previously undescribed area as a likely hot spot of social modulation.

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Social bonding: regulation by neuropeptides

Cited by 70 publications

References 187 publications

Salivary oxytocin in adolescents with conduct problems and callous-unemotional traits

Salivary oxytocin in adolescents with conduct problems and callous-unemotional traits

Neurobiological mechanisms of social attachment and pair bonding

Seasonal Variation in Group Size Is Related to Seasonal Variation in Neuropeptide Receptor Density

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