Social Cognition in Individuals with Progressive Multiple Sclerosis: A Pilot Study Using TASIT-S

Genova, Helen M.; McDonald, Skye

doi:10.1017/s1355617719001371

Cited by 13 publications

(7 citation statements)

References 16 publications

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“…Previous studies have indicated that MS can impair emotion perception in visual (Cotter et al., 2016) and auditory (Kraemer et al., 2013) modalities. The current study extended a recent pilot study (Genova and MacDonald, 2020) to indicate that pwMS show equivalent impairments on a more ecologically valid multimodal emotion perception task. On a video‐based task which included dynamic visual and auditory information pwMS were less accurate at identifying emotions compared with healthy counterparts.…”

Section: Discussionsupporting

confidence: 75%

“…(2019) found no effect of MS. Genova, Cagna, Chiaravalloti, DeLuca, and Lengenfelder (2016) have shown that pwMS score worse than controls on multimodal assessments of another aspect of theory of mind: understanding sarcasm and lies. However, to date there is only one study that we are aware that looked directly at the effects of MS on multimodal emotion perception: Genova and MacDonald (2020) reported in a pilot study that 15 participants with progressive MS were impaired on The Awareness of Social Inference Test—Short Form (TASIT‐S). In the current study, as well as unimodal emotion labelling tasks, participants completed the full version of the TASIT multimodal emotion perception task.…”

Section: Introductionmentioning

confidence: 99%

“…However, theory of mind assessments are by their nature cognitively complex, and there is little direct evidence to date on the role of executive function and processing speed in more straightforward multimodal emotion perception in MS. In a pilot study of 15 pwMS, Genova and MacDonald (2020) reported that there were not significant correlations between a brief version of the emotion perception task (TASIT‐S) and measures of speed or executive function. However, it would be useful to further explore this issue in a larger sample with the full‐length multimodal task.…”

Section: Introductionmentioning

confidence: 99%

“…The dependent variable was the percentage accuracy. A recent study indicated that pwMS were impaired compared with healthy controls on a shortened version of this task (Genova & MacDonald, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Multiple sclerosis, emotion perception and social functioning

Radlak

Cooper

Summers

et al. 2021

Journal of Neuropsychology

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People with multiple sclerosis (MS) can experience problems in interpreting others’ emotions from faces or voices. However, to date little is known about whether difficulties in emotion perception in MS are related to broader aspects of social functioning. Also, there are few studies reporting the effect of MS on more ecologically valid assessments of emotion perception using multimodal videos. The current study looks at (1) the effect of MS on perceiving emotions from faces, voices and multimodal videos; (2) the possible role of slowed processing and executive dysfunction in emotion perception problems in MS and (3) the relationship between emotion perception and broader social functioning in MS. 53 people with MS and 31 healthy controls completed tasks of emotion perception and cognition, and assessed their levels of social support and social participation. Participants with MS performed worse than demographically matched controls on all measures of emotion perception. Emotion perception performance was related to cognitive measures in those with MS. Also, significant associations were found between emotion perception difficulties in MS and poorer social function. In particular, people with MS who had poorer emotion perception also reported lower levels of social support from their friends, and regression analysis showed that this prediction was maintained even when disease severity and cognitive function were taken into account. These results show that problems with emotion perception in MS extend to more realistic tasks and may predict key aspects of social functioning.

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multiple sclerosis, emotion perception and social functioning

Radlak

Cooper

Summers

et al. 2021

Journal of Neuropsychology

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“…Cognitive impairment has been recognized as a common symptom in MS, with an estimated lifetime occurrence of 40-65% (5)(6)(7). The cognitive domains generally affected include executive functioning, information processing speed, attention, and memory (8,9), and social cognition (10)(11)(12)(13)(14). Social cognition, a basic means for the individual to perceive, encode, store, retrieve, and regulate information regarding other people and the self (15), has a remarkable impact on interpersonal communication and QoL (16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis

et al. 2021

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Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. Studies have shown that MS disrupts several social cognitive abilities [including empathy and theory of mind (ToM)]. Overall ToM deficits in MS are well documented, but how the specific ToM subcomponents and empathic capacity are affected remains unclear. For this meta-analysis, we searched PubMed, Web of Science, and Embase from inception to July 2020. Effect sizes were calculated using Hedges g with a random-effects model. Thirty-three studies were included. Relative to healthy controls (HCs), patients with MS were moderately impaired in overall empathy (g = −0.67), overall ToM (g = −74), cognitive ToM (g = −0.72), and the overlapping domains of cognitive empathy/affective ToM (g = −0.79); no group differences were identified for affective empathy (g = −0.19). Compared with HCs, patients with relapsing-remitting MS (RRMS) and progressive MS were impaired in overall empathy, overall ToM, cognitive ToM, and cognitive empathy/affective ToM, without significant RRMS–progressive MS differences in impairment degree. We conducted the first meta-analytic review investigating the empathy and ToM functioning patterns in patients with MS and examined the overlapping and distinct subcomponents of these constructs. The findings suggest differential impairment of the core aspects of social cognitive processing in patients with MS, which may importantly inform the development of structured social cognitive MS interventions.

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The neural substrates of social cognition deficits in newly diagnosed multiple sclerosis patients

Ziccardi,

Genova,

Colato

et al. 2024

Ann Clin Transl Neurol

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ObjectiveCognitive and affective symptoms in multiple sclerosis (MS) can be independently impaired and have different pathways of progression. Cognitive alterations have been described since the earliest MS stages; by contrast, the social cognition (SC) domain has never been investigated in the first year from MS diagnosis. We aimed to evaluate SC and unravel its neural bases in newly diagnosed MS patients.MethodsSeventy MS patients underwent at diagnosis a 3 T‐MRI and a neuropsychological/SC assessment (median time between diagnosis and MRI/cognitive evaluation = 0 months). We tested two matched reference samples: 31 relapsing–remitting MS patients with longer course (mean ± SD disease duration = 7.0 ± 4.5 years) and 38 healthy controls (HCs). Cortical thicknesses (CTh) and volumes of brain regions were calculated.ResultsNewly diagnosed MS patients performed significantly lower than HCs in facial emotion recognition (global: p < 0.001; happiness: p = 0.041, anger: p = 0.007; fear: p < 0.001; disgust: p = 0.004) and theory of mind (p = 0.005), while no difference was found between newly diagnosed and longer MS patients. Compared to lower performers, higher performers in facial emotion recognition showed greater volume of amygdala (p = 0.032) and caudate (p = 0.036); higher performers in theory of mind showed greater CTh in lingual gyrus (p = 0.006), cuneus (p = 0.024), isthmus cingulate (p = 0.038), greater volumes of putamen (p = 0.016), pallidum (p = 0.029), and amygdala (p = 0.032); patients with higher empathy showed lower cuneus CTh (p = 0.042) and putamen volume (p = 0.007).InterpretationsSC deficits are present in MS patients since the time of diagnosis and remain persistent along the disease course. Specific basal, limbic, and occipital areas play a significant role in the pathogenesis of these alterations.

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Social Cognition in Individuals with Progressive Multiple Sclerosis: A Pilot Study Using TASIT-S

Cited by 13 publications

References 16 publications

Multiple sclerosis, emotion perception and social functioning

Multiple sclerosis, emotion perception and social functioning

Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis

The neural substrates of social cognition deficits in newly diagnosed multiple sclerosis patients

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