Social impairment and stigma in genetic generalized epilepsies

Gabriel, Denis; Samões, Raquel; Freitas, Joel; Lopes, João; Ramalheira, João; Silva, António Martins da; Chaves, João

doi:10.1016/j.yebeh.2019.106886

Cited by 14 publications

(17 citation statements)

References 57 publications

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“…In a recent study by Gabriel et al, 28% of 226 people with GGE felt stigmatized. Fifty‐one (22%) were unemployed, which was more than the number of people with refractory epilepsy (n = 39, 17%) 7 …”

Section: Discussionmentioning

confidence: 99%

“…It is also a phase involving important choices, like education and future work. In addition to medical concerns, people with epilepsy are often faced with other people's anxiety and concerns regarding seizures, which may give rise to stigma and exclusion 5–7 . Being diagnosed with epilepsy in adolescence represents a negative influence and may increase the risk of dropout.…”

Section: Introductionmentioning

confidence: 99%

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Predictors of high school dropout, anxiety, and depression in genetic generalized epilepsy

et al. 2020

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Affective disorders are overrepresented in epilepsy, and people with epilepsy may be at risk of dropping out from school. The aim of the present study was to assess factors influencing high school dropout, anxiety, and depression in genetic generalized epilepsy (GGE). One hundred and ten people with GGE aged 19‐40 years underwent a clinical interview, including the Hospital Anxiety and Depression Scale (HADS) questionnaire. Potential predictors of high school dropout were analyzed with logistic regression, and factors influencing total HADS score were analyzed with linear regression. Having felt excluded because of epilepsy was significantly associated with high school dropout (odds ratio 7.80, P = .009), as was total HADS score (odds ratio 1.22, P = .005). If a participant was currently employed or undergoing education, previous high school dropout was less likely (odds ratio 0.07, P = .005). High school dropout was associated with increased current anxiety and depression (β = 0.32, P = .005). Epilepsy severity (current drug resistance, current polytherapy, and active generalized tonic‐clonic seizures) was not associated with high school dropout, nor with total HADS score. The issue of stigma in epilepsy must be thoroughly addressed in comprehensive care and may be as important as seizure control when it comes to education and quality of life.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predictors of high school dropout, anxiety, and depression in genetic generalized epilepsy

et al. 2020

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“…The CAE/JAE group also showed a higher prevalence of depression (17%) when compared to control (0%); however, both disorders failed to show statistical significance. Another study by Gabriel et al 22 found that patients with JAE had more mood disorders (19.6%), but less anxiety (17.4%) than the general population (19.3% and 25.8%, respectively), although this difference failed to reach significance.…”

Section: Human Studiesmentioning

confidence: 93%

“…Seven human studies describing the association of AS with depression and anxiety were included. With two exceptions, 21,22 all studies were conducted in a pediatric population with the Kiddie Schedule for Affective Disorders and Schizophrenia as the most commonly used diagnostic tool. The participants' characteristics, diagnostic tools, and outcomes are described in Table 1.…”

Section: Human Studiesmentioning

confidence: 99%

Absence seizures and their relationship to depression and anxiety: Evidence for bidirectionality

et al. 2021

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Absence seizures (AS), presenting as short losses of consciousness with staring spells, are a common manifestation of childhood epilepsy that is associated with behavioral, emotional, and social impairments. It has also been suggested that patients with AS are more likely to suffer from mood disorders such as depression and anxiety. This systematic review and meta-analysis synthesizes human and animal models that investigated mood disorders and AS. Of the 1019 scientific publications identified, 35 articles met the inclusion criteria for this review. We found that patients with AS had greater odds of developing depression and anxiety when compared to controls (odds ratio = 4.93, 95% confidence interval = 2.91-8.35, p < .01). The included studies further suggest a strong correlation between AS and depression and anxiety in the form of a bidirectional relationship. The current literature emphasizes that these conditions likely share underlying mechanisms, such as genetic predisposition, neurophysiology, and anatomical pathways. Further research will clarify this relationship and ensure more effective treatment for AS and mood disorders.

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“…Like Guillermo Kahlo, the patients had demanding professions, for example, civil engineering and computer programming. Depressive mood disorders and other psychiatric comorbidities are also common in persons with juvenile absence epilepsy [21].…”

Section: Guillermo Kahlo’s Seizuresmentioning

confidence: 99%

Portrait of My Father: Frida Kahlo’s Intimate Relation to Epilepsy

Carrazana

2021

Eur Neurol

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The painting Portrait of My Father (1951) by the Mexican painter, Frida Kahlo, is discussed by the author within the context of epilepsy and biographical events in the lives of both Frida and her father, the German Mexican photographer Guillermo Kahlo. The biographical accounts of the photographer’s seizures are suggestive of juvenile absence epilepsy but cannot discount the possibility of posttraumatic epilepsy of mesial frontal origin.

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Social impairment and stigma in genetic generalized epilepsies

Cited by 14 publications

References 57 publications

Predictors of high school dropout, anxiety, and depression in genetic generalized epilepsy

Predictors of high school dropout, anxiety, and depression in genetic generalized epilepsy

Absence seizures and their relationship to depression and anxiety: Evidence for bidirectionality

<b><i>Portrait of My Father:</i></b> Frida Kahlo’s Intimate Relation to Epilepsy

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