Social interactions unmask sex differences in humoral immunity in voles

Klein, Sabra L.; Nelson, Randy J.

doi:10.1006/anbe.1998.1038

Cited by 28 publications

(14 citation statements)

References 35 publications

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“…These signals also can be critical for establishing sex differences in the immunocompetence. For example, humoral immune response to keyhole limpet haemocyanin (KLH) were approximately equal in male and female meadow voles and prairie voles, when they were housed individually [122]. Housing in pairs revealed the sex-related differences of humoral immunity in polygynous meadow vole, but there were no differences in monogamous prairie vole.…”

Section: Immunosuppressive Effects Of Sexual Chemical Signalsmentioning

confidence: 99%

The Role of the Immune System in Behavioral Strategies of Reproduction

Мошкин

Gerlinskaya

Evsikov

2000

Journal of Reproduction and Development

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Abstract. Since both reproduction and immunocompetence are costly, the negative reciprocal relationships between these functions were found in many species. Due to reproductive immunosuppression, some fraction of seasonally breeding populations of small mammals reproduces in the first breeding season, while others reproduce in the next one. Elevation of breeding efforts under the increased risk of mortality and the reproductive delay until recovery are the polar variants of mating behavior of parasitized individuals. However the parasite-induced changes of odor, visual or acoustic signals limit the mating success of the infected hosts. The direct influence of the immune system, regularly activated by infections, to chemicals signals can be answer to the question: why these signals are honest? Decrease of a strange infection risk by kin breeding can be a satisfactory strategy of an isolated population. Nevertheless, many species follow the inbreeding avoidance strategy, where the major histocompatibility complex (MHC) genes play key role in kin recognition. The advantage of MHC heterozygosity was found at the all steps of the breeding cycle; including mating choice, fertilization, pre-and postnatal development. So, the relationships between immune system and neuroendocrine regulation of behavior give proximate explanations of the evolutionary stable strategies of breeding behavior.

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Section: Immunosuppressive Effects Of Sexual Chemical Signalsmentioning

confidence: 99%

The Role of the Immune System in Behavioral Strategies of Reproduction

Мошкин

Gerlinskaya

Evsikov

2000

Journal of Reproduction and Development

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“…19,26). These studies demonstrated that sex differences in cell-mediated and humoral immune function are enhanced by social housing in polygynous voles (18,20). Therefore, in general, short days enhance immune responses (25,31), and nonagonistic social relationships facilitate recovery from immune challenges (5,11,17).…”

mentioning

confidence: 91%

“…It has been hypothesized that the energetic savings attained by seasonal suspension of reproduction liberates energy for immune function, thereby enhancing immune responses in short-day animals (7). Although additional environmental cues (e.g., temperature, food availability, precipitation, and social cues) have also been studied separately or in conjunction with photoperiod manipulation (8,10,20,28), photoperiod generally appears to be the most influential cue for seasonal adaptations.…”

mentioning

confidence: 99%

Social environment modulates photoperiodic immune and reproductive responses in adult male white-footed mice(Peromyscus leucopus)

Pyter¹,

Neigh²,

Nelson³

2005

American Journal of Physiology-Regulatory, Integrative and Comp

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Social cues may interact with photoperiod to regulate seasonal adaptations in photoperiod-responsive rodents. Specifically, photoperiod-induced adjustments (e.g., reproduction and immune function) may differ among individuals in heterosexual pairs, same-sex pairs, or isolation. Heterosexual cues may be more influential, based on their potential fitness value, than same-sex cues or no social cues. The present study examined the effects of pair (with a male or female) or individual housing on reproductive and immune responses in male white-footed mice ( Peromyscus leucopus) maintained in long or short photoperiods. Female pairing did not affect reproductive responses in short-day males. In long days, however, the presence of a female increased both testosterone concentrations and testes mass compared with individually housed and male-paired mice, respectively. Short-day, individually housed males enhanced delayed-type hypersensitivity (DTH) responses compared with single-housed mice in long days, but all paired groups decreased DTH responses regardless of photoperiod. The lack of enhanced DTH response in male mice paired with females coincided with reduced circulating corticosterone concentrations in both photoperiod treatments. Together, these results suggest that social environment may have important modulatory effects on photoperiod-regulated immune responses in male white-footed mice.

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“…Assessing immune responses can be difficult because the vertebrate immune system is an inter-related system (Roitt et al 1998) and encountering multiple threats may influence the ability of individuals to produce strong immune response simultaneously (Mosmann et al 1986a, Graham 2002. Many studies report a negative correlation between antibody mediated immunity and cutaneous swelling in response to a mitogen, a generalized measure of cell-mediated immunity (Klein and Nelson 1999, González et al 1999, Buchanan et al 2003, Faivre et al 2003. For example, house sparrows Passer domesticus producing strong humoral immune responses showed weak cell-mediated inflammation in response to a mitogen (Buchanan et al 2003), while prior wounding reduced cell-mediated immune responses in white-footed mice Peromyscus leucopus (Martin et al 2006c).…”

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confidence: 99%

The ability to mount multiple immune responses simultaneously varies across the range of the tree swallow

Ardia¹

2007

Ecography

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Variation in immune responses is an important part of life history variation. When correlations between multiple immune measures are reported, studies report different patterns. I tested whether the correlation between levels of immune response was consistent across a species range. The ability of tree swallows Tachycineta bicolor to simultaneously produce immune responses to both a humoral immune response and T-cell mediated local inflammation to PHA was tested at three sites that span the breeding range. Females in Tennessee maintained stronger PHA responses than did females in either New York or Alaska. In New York and Alaska, individuals that produced strong PHA responses produced low levels of antibodies to a humoral challenge of sheep red blood cells (SRBC). However, in Tennessee, individuals that showed strong local PHA inflammation also mounted strong responses to SRBC. Increasing daily daytime temperatures led to increased PHA response, but there were no differences in the effect of temperature among sites. These results indicate spatial and/or temporal variation occurs in the ability to produce multiple immune responses simultaneously; this pattern suggests important geographic (or temporal) differences in factors driving investment in immune activity. In addition, these results suggest that studies extrapolating results across populations should be careful to consider geographic variation in immune activity.

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Social interactions unmask sex differences in humoral immunity in voles

Cited by 28 publications

References 35 publications

The Role of the Immune System in Behavioral Strategies of Reproduction

The Role of the Immune System in Behavioral Strategies of Reproduction

Social environment modulates photoperiodic immune and reproductive responses in adult male white-footed mice(Peromyscus leucopus)

The ability to mount multiple immune responses simultaneously varies across the range of the tree swallow

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