Social isolation is associated with reduced neurogenesis, impaired spatial working memory performance, and altered anxiety levels in male rats

Karimian, Morteza; Famitafreshi, Hamidreza; Fanaei, Hamed; Attari, Fatemeh; Fatima, Sulail

doi:10.2147/oaap.s84327

Cited by 10 publications

(8 citation statements)

References 43 publications

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“…Similarly, the study by Famitafreshi et al supported our findings, demonstrating the adverse effects of SI on the hippocampus and cerebral cortex, which have a key role in learning, memory, and cognitive functions, as well as dopamine levels [70,71]. On the other hand, treatment with PUN in the SI and/or MnCl 2 -intoxicated groups significantly ameliorated all the pervious alternations, compared to their corresponding control groups (SI, MnCl 2 , or SI with MnCl 2 ).…”

Section: Discussionsupporting

confidence: 91%

Punicalagin’s Protective Effects on Parkinson’s Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway

Salem,

Abu-Elfotuh,

Alzahrani

et al. 2023

Pharmaceutics

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Parkinson’s disease (PD) is a gradual deterioration of dopaminergic neurons, leading to motor impairments. Social isolation (SI), a recognized stressor, has recently gained attention as a potential influencing factor in the progress of neurodegenerative illnesses. We aimed to investigate the intricate relationship between SI and PD progression, both independently and in the presence of manganese chloride (MnCl2), while evaluating the punicalagin (PUN) therapeutic effects, a natural compound established for its cytoprotective, anti-inflammatory, and anti-apoptotic activities. In this five-week experiment, seven groups of male albino rats were organized: G1 (normal control), G2 (SI), G3 (MnCl2), G4 (SI + MnCl2), G5 (SI + PUN), G6 (MnCl2 + PUN), and G7 (SI + PUN + MnCl2). The results revealed significant changes in behavior, biochemistry, and histopathology in rats exposed to SI and/or MnCl2, with the most pronounced effects detected in the SI rats concurrently exposed to MnCl2. These effects were associated with augmented oxidative stress biomarkers and reduced antioxidant activity of the Nrf2/HO-1 pathway. Additionally, inflammatory pathways (HMGB1/RAGE/TLR4/NF-ᴋB/NLRP3/Caspase-1 and JAK-2/STAT-3) were upregulated, while dysregulation of signaling pathways (PI3K/AKT/GSK-3β/CREB), sustained endoplasmic reticulum stress by activation PERK/CHOP/Bcl-2, and impaired autophagy (AMPK/SIRT-1/Beclin-1 axis) were observed. Apoptosis induction and a decrease in monoamine levels were also noted. Remarkably, treatment with PUN effectively alleviated behaviour, histopathological changes, and biochemical alterations induced by SI and/or MnCl2. These findings emphasize the role of SI in PD progress and propose PUN as a potential therapeutic intervention to mitigate PD. PUN’s mechanisms of action involve modulation of pathways such as HMGB1/RAGE/TLR4/NF-ᴋB/NLRP3/Caspase-1, JAK-2/STAT-3, PI3K/AKT/GSK-3β/CREB, AMPK/SIRT-1, Nrf2/HO-1, and PERK/CHOP/Bcl-2.

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Section: Discussionsupporting

confidence: 91%

Punicalagin’s Protective Effects on Parkinson’s Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway

Salem,

Abu-Elfotuh,

Alzahrani

et al. 2023

Pharmaceutics

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“…Additionally, Akillioglu et al (2015) found that rodents deprived from contact with the progenitor showed changes in the hippocampus as well as impaired spatial memory. In addition, a study accomplished by Karimian and Attari (2015) reported that in a sample of twenty male rats, neurogenesis in the dentate gyrus of the hippocampus was significantly lower in isolated rats when compared to the group of social rats. Further studies with animal models also suggest that rodents exposed to long-term social isolation display decreased BDNF expression in the hippocampus, although the mechanisms underlying this results are not known (Eckert and Abraham, 2012; Murínová et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Attachment Dimensions and Spatial Navigation in Female College Students: The Role of Comfort With Closeness and Confidence in Others

et al. 2019

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There is preliminary evidence suggesting that hippocampal functioning is associated with attachment style. However, it is unknown if attachment is also associated with hippocampal-related cognitive function such as spatial learning and recall. This study aims to verify if attachment dimensions are associated with spatial learning and recall. Sixty-five female participants were recruited and were evaluated using the Adult Attachment Scale-R and tested on a virtual maze navigation task (VMT) at one moment (exploratory trial + 3 trials) and 24 h later (3 trials). There was a significant Moment × Trial × Close-Depend interaction for the outcome time, F (2,126) = 3.807, p = 0.025, with post hoc analysis indicating that the High Close-Depend group displayed significant improvements between Trial 1 and Trial 3 in the post-test assessment. Conversely, the Low Close-Depend group displayed significant improvements between Trial 1and Trial 3 but on the pre-test assessment. Furthermore, the Low Close-Depend group presented significant better performance in pre-test Trial 3 in comparison to the High Close-Depend group. Thereby, it seems that low comfort with proximity and trust in others is associated with reduced spatial recall, although spatial learning performance was actually superior in these participants. It is possible that reduced exposure to social interaction and meaningful relationships may be reduced in the Low Close-Depend group, leading to modifications in hippocampal function and, ultimately, reduced spatial recall. Oppositely, participants in the High Close-Depend group may not display typical spatial learning in the proposed task as they are more willing to freely explore the presented environment.

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“…Psychosocial stressors can include the disruption of social contact as well as agonistic encounters with conspecifics or predators. For social animals, prolonged disruptions in social interaction can negatively impact neurogenesis, although the nature and extent of this impact may vary with factors such as age, sex, and species [72,73,74,138]. Isolation from age-matched conspecifics and repeated isolation from offspring reduces new cell proliferation or survival in the hippocampus [82], a finding consistent with other studies highlighting volumetric and morphological changes in the ventral hippocampus during chronic stress [139,140,141,142].…”

Section: Conclusion and Future Directionmentioning

confidence: 99%

The Impact of Ethologically Relevant Stressors on Adult Mammalian Neurogenesis

2019

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Adult neurogenesis—the formation and functional integration of adult-generated neurons—remains a hot neuroscience topic. Decades of research have identified numerous endogenous (such as neurotransmitters and hormones) and exogenous (such as environmental enrichment and exercise) factors that regulate the various neurogenic stages. Stress, an exogenous factor, has received a lot of attention. Despite the large number of reviews discussing the impact of stress on adult neurogenesis, no systematic review on ethologically relevant stressors exists to date. The current review details the effects of conspecifically-induced psychosocial stress (specifically looking at the lack or disruption of social interactions and confrontation) as well as non-conspecifically-induced stress on mammalian adult neurogenesis. The underlying mechanisms, as well as the possible functional role of the altered neurogenesis level, are also discussed. The reviewed data suggest that ethologically relevant stressors reduce adult neurogenesis.

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Social isolation is associated with reduced neurogenesis, impaired spatial working memory performance, and altered anxiety levels in male rats

Cited by 10 publications

References 43 publications

Punicalagin’s Protective Effects on Parkinson’s Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway

Punicalagin’s Protective Effects on Parkinson’s Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway

Attachment Dimensions and Spatial Navigation in Female College Students: The Role of Comfort With Closeness and Confidence in Others

The Impact of Ethologically Relevant Stressors on Adult Mammalian Neurogenesis

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