Social stress‐potentiated methamphetamine seeking

Blouin, Ashley M.; Pisupati, Swathi; Hoffer, Colton G.; Hafenbreidel, Madalyn; Jamieson, Sarah E.; Rumbaugh, Gavin; Miller, Courtney A.

doi:10.1111/adb.12666

Cited by 9 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Less is known about the stagesetting effects of stress in other drug classes. Blouin et al (2019) have found that social defeat stress potentiates methamphetamineinduced reinstatement and the corresponding Fos response in the basolateral amygdala following self-administration in rats. However, the degree to which stress can potentiate drug seeking with other classes of drugs and the degree to which there is circuit and mechanistic overlap awaits further investigation.…”

Section: G Ener Aliz Ati On Of Find Ing S Cross Drug CL a Ss E Smentioning

confidence: 99%

Neurochemical mechanisms and neurocircuitry underlying the contribution of stress to cocaine seeking

Caccamise

Newenhizen

Mantsch

2021

Journal of Neurochemistry

View full text Add to dashboard Cite

In individuals with substance use disorders, stress is a critical determinant of relapse susceptibility. In some cases, stressors directly trigger cocaine use. In others, stressors interact with other stimuli to promote drug seeking, thereby setting the stage for relapse. Here, we review the mechanisms and neurocircuitry that mediate stress-triggered and stress-potentiated cocaine seeking. Stressors trigger cocaine seeking by activating noradrenergic projections originating in the lateral tegmentum that innervate the bed nucleus of the stria terminalis to produce beta adrenergic receptor-dependent regulation of neurons that release corticotropin releasing factor (CRF) into the ventral tegmental area (VTA). CRF promotes the activation of VTA dopamine neurons that innervate the prelimbic prefrontal cortex resulting in D1 receptor-dependent excitation of a pathway to the nucleus accumbens core that mediates cocaine seeking. The stage-setting effects of stress require glucocorticoids, which exert rapid non-canonical effects at several sites within the mesocorticolimbic system. In the nucleus accumbens, corticosterone attenuates dopamine clearance via the organic cation transporter 3 to promote dopamine signaling. In the prelimbic cortex, corticosterone mobilizes the endocannabinoid, 2-arachidonoylglycerol (2-AG), which produces CB1 receptor-dependent reductions in inhibitory transmission, thereby increasing excitability of neurons which comprise output pathways responsible for cocaine seeking. Factors that influence the role of stress in cocaine seeking, including prior history of drug use, biological sex, chronic stress/co-morbid stress-related disorders, adolescence, social variables, and genetics are discussed.Better understanding when and how stress contributes to drug seeking should guide the development of more effective interventions, particularly for those whose drug use is stress related.

show abstract

Section: G Ener Aliz Ati On Of Find Ing S Cross Drug CL a Ss E Smentioning

confidence: 99%

Neurochemical mechanisms and neurocircuitry underlying the contribution of stress to cocaine seeking

Caccamise

Newenhizen

Mantsch

2021

Journal of Neurochemistry

View full text Add to dashboard Cite

show abstract

“…Indeed, unresolved PTSD is largely considered to be a chronic stress disorder [ 103 ]. These studies are paralleled by pre-clinical studies in rodents reporting that stress triggers relapse to Meth and increases drug-seeking [ 8 , 104 ].…”

Section: Mechanisms Of Stress and Meth Vascular Toxicitymentioning

confidence: 99%

“…Stress is a well-documented risk factor for the development of addiction and the vulnerability to relapse. The effects of stress also influence patterns of alcohol and Meth abuse [ 8 ] and can further contribute to a triad of Meth, alcohol abuse, and stress.…”

Section: Introductionmentioning

confidence: 99%

Toxic Effects of Methamphetamine on Perivascular Health: Co-morbid Effects of Stress and Alcohol Use Disorders

Rodríguez

Yamamoto

2021

View full text Add to dashboard Cite

: Methamphetamine (Meth) abuse presents a worldwide problem and commonly occurs with stress and/or alcohol use disorders. Regardless, the biological causes and consequences of these co-morbidities are unclear. Whereas the mechanisms of Meth, stress and alcohol abuse have been examined individually and well-characterized, these processes overlap significantly and can impact the neural and peripheral consequences of Meth. This review focuses on the deleterious cardio- and cerebrovascular effects of Meth, stress, alcohol abuse and their comorbid effects on the brain and periphery. Points of emphasis are on the composition of the blood brain barrier and their effects on the heart and vasculature. The autonomic nervous system, inflammation, and oxidative stress are specifically highlighted as common mediators of the toxic consequences to vascular and perivascular health. Given that a significant portion of the Meth abusing population also presents with stress and alcohol use disorders prompts a need to understand the mechanisms underlying their comorbidities. Little is known about their possible convergent effects and therefore, the purpose of this critical review is to identify shared mechanisms of Meth, chronic stress and alcohol abuse that contribute to the dysfunction of vascular health and underscore the need for studies that directly address their interactions.

show abstract

“…Using the SA paradigm, it has been demonstrated that exposure to social stress increases the reinforcing effects of drugs of abuse[ 136 - 139 ]. Recently, resilience to these effects has also been studied using different types of social stress and drugs of abuse, such as cocaine[ 140 - 143 ], methamphetamine[ 144 ] and alcohol[ 145 - 147 ].…”

Section: Behavioral Paradigms To Study Stress-related Psychiatric Disordersmentioning

confidence: 99%

“…Interestingly, the defeat latency during the episode of SD correlated with reinstatement values and c-Fos-immunoreactivity in the basolateral amygdala; priming-induced reinstatement and c-Fos were both potentiated in rapidly defeated rats. Conversely, these effects were not observed in rats that were undefeated during the social encounter, but inactivation of the basolateral amygdala induced potentiation of reinstatement, suggesting that this structure mediates resilience against SD stress[ 144 ]. The positive correlation between reinstatement and passive coping (high values of reinstatement in animals with lower latency defeat) was reported in another study, although the authors questioned its real meaning, and proposed that active coping behaviors during SD episodes were associated with the magnitude of reinstatement[ 257 ].…”

Section: Resilience To the Effects Of Social Defeat On The Rewarding Properties Of Drugs Of Abusementioning

confidence: 99%

Resilience to the effects of social stress on vulnerability to developing drug addiction

Calpe-López¹,

Martínez-Caballero²,

García-Pardo³

et al. 2022

WJP

View full text Add to dashboard Cite

We review the still scarce but growing literature on resilience to the effects of social stress on the rewarding properties of drugs of abuse. We define the concept of resilience and how it is applied to the field of drug addiction research. We also describe the internal and external protective factors associated with resilience, such as individual behavioral traits and social support. We then explain the physiological response to stress and how it is modulated by resilience factors. In the subsequent section, we describe the animal models commonly used in the study of resilience to social stress, and we focus on the effects of chronic social defeat (SD), a kind of stress induced by repeated experience of defeat in an agonistic encounter, on different animal behaviors (depression- and anxiety-like behavior, cognitive impairment and addiction-like symptoms). We then summarize the current knowledge on the neurobiological substrates of resilience derived from studies of resilience to the effects of chronic SD stress on depression- and anxiety-related behaviors in rodents. Finally, we focus on the limited studies carried out to explore resilience to the effects of SD stress on the rewarding properties of drugs of abuse, describing the current state of knowledge and suggesting future research directions.

show abstract

Social stress‐potentiated methamphetamine seeking

Cited by 9 publications

References 42 publications

Neurochemical mechanisms and neurocircuitry underlying the contribution of stress to cocaine seeking

Neurochemical mechanisms and neurocircuitry underlying the contribution of stress to cocaine seeking

Toxic Effects of Methamphetamine on Perivascular Health: Co-morbid Effects of Stress and Alcohol Use Disorders

Resilience to the effects of social stress on vulnerability to developing drug addiction

Contact Info

Product

Resources

About