Social stress-related behavior affects hippocampal cell proliferation in mice

Mitra, Rupshi; Sundlass, Karan; Parker, Karen J.; Schatzberg, Alan F.; Lyons, David M.

doi:10.1016/j.physbeh.2006.05.047

Cited by 84 publications

(64 citation statements)

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“…In addition, as behavioural and gonadal hormone profiles are more divergent for breeders and subordinates than male and female naked mole-rats, we hypothesized that DCX expression would vary with social status. In line with prior research demonstrating a neurogenic advantage for dominant versus subordinate individuals (Gould et al, 1997;1998;Czeh et al, 2001;Van der Hart et al, 2002;Kozorovitskiy and Gould, 2004;Mitra et al, 2006;Simon et al, 2005;Yap et al, 2006;Czeh et al, 2007, Thomas et al, 2007van Bokhoven et al, 2011), and reproductively active versus inactive animals , we predicted that breeding naked mole-rats would demonstrate higher DCX expression than subordinates. Finally, we expected that DCX…”

Section: The Present Studysupporting

confidence: 77%

“…Conversely, aversive interactions with dominant and aggressive conspecifics reduce cell proliferation and survival in the DG, suggesting that hippocampal neurogenesis is sensitive to status and social threat cues (Gould et al, 1997;1998;Czeh et al, 2001;Van der Hart et al, 2002;Kozorovitskiy and Gould, 2004;Mitra et al, 2006;Simon et al, 2005;Yap et al, 2006;Czeh et al, 2007, Thomas et al, 2007van Bokhoven et al, 2011).…”

Section: Social Control Of Adult Neurogenesismentioning

confidence: 99%

“…In fish, birds, tree shrews, primates, and traditional laboratory rodents, subordinate individuals have reduced cell proliferation and/or neurogenesis in the hippocampus (Gould et al, 1997;1998;Yap et al, 2006Czeh et al, 20012002;van der Hart et al, 2002;Kozorovitskiy and Gould, 2004;Pravosudov et al, 2005;Simon et al, 2005;Czeh et al, 2007;Thomas et al, 2007;Van Bokhoven et al, 2011;Maruska et al, 2012). Though extrahippocampal neurogenesis has received considerably less attention, what few studies have been done report that status-associated differences are not observed in the BLA (Mitra et al, 2006) or SVZ (Czeh et al, 2007). It has been suggested that stress induced by contact with dominant conspecifics, and concomitant elevations in circulating glucocorticoids (GCs), suppress subordinate neurogenesis across vertebrates, resulting in behavioural inhibition (Thomas et al, 2007;Lehmann et al, 2013).…”

Section: Adult Neurogenesis and Social Factorsmentioning

confidence: 99%

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Social regulation of adult neurogenesis in a eusocial mammal

et al. 2014

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The present study examined social status and adult neurogenesis in the naked mole rat. These animals live in large colonies with a strict reproductive dominance hierarchy; one female and 1-3 males breed, while other members are subordinate and reproductively suppressed. We examined whether social status affects doublecortin (DCX; a marker for immature neurons) immunoreactivity in the dentate gyrus, piriform cortex (PCx), and basolateral amygdala (BLA) by comparing breeders to subordinates. We also examined subordinates removed from their colony and paired with opposite-or same-sex conspecifics for 6 months. Breeders had reduced DCX immunoreactivity in all areas, with BLA effects confined to females. Effects of housing condition were region-specific, with higher PCx DCX immunoreactivity observed in oppositethan same-sex paired subordinates regardless of gonadal status. The opposite pattern was observed in the BLA. Future work will clarify whether findings are attributable to status differences in stress, behavioural plasticity, or life stage.iii

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Section: The Present Studysupporting

confidence: 77%

Section: Social Control Of Adult Neurogenesismentioning

confidence: 99%

Section: Adult Neurogenesis and Social Factorsmentioning

confidence: 99%

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Social regulation of adult neurogenesis in a eusocial mammal

et al. 2014

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“…Alternatively, and considering that physical and psychological stress lead to a decrease in hippocampal cell proliferation and neurogenesis [51][52][53], rewarded running may pose a 'stressful' situation, in which running is no more performed on a strictly voluntary basis.…”

Section: Running For a Rewardmentioning

confidence: 99%

A reward increases running-wheel performance without changing cell proliferation, neuronal differentiation or cell death in the dentate gyrus of C57BL/6 mice

Klaus

Hauser

Slomianka

et al. 2009

Behavioural Brain Research

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A reward increases running-wheel performance without changing cell proliferation, neuronal differentiation or cell death in the dentate gyrus of C57BL/6 mice Klaus, F; Hauser, T; Slomianka, L; Amrein, I; Lipp, H P Klaus, F; Hauser, T; Slomianka, L; Amrein, I; Lipp, H P (2009). A reward increases running-wheel performance without changing cell proliferation, neuronal differentiation or cell death in the dentate gyrus of C57BL/6 mice. A reward increases running-wheel performance without changing cell proliferation, neuronal differentiation or cell death in the dentate gyrus of C57BL/6 mice Abstract Exercise is one of the best-known stimulators of adult hippocampal neurogenesis, but it is not known if voluntary changes in the intensity of exercise are accompanied by changes in neurogenesis. In this study we investigated whether a reward influences the performance in a running wheel and the rate of cell proliferation, neuronal differentiation and cell death in C57BL/6 mice. Mice had free access to a running wheel during the first week of the experiment. In the second week, animals were rewarded for their performance and compared to normal voluntary running and control mice. A reward significantly increased the performance by 78% when compared to the non-rewarded performance of the first week.The performance of the non-rewarded runners remained relatively constant. Fourteen days of exercise significantly increased cell proliferation by 27% and the number of doublecortin immunoreactive cells by 46%. A reward and the associated increase of performance did not modulate proliferation, cell death or the number of cells entering the neuronal lineage. We suggest that, in C57BL/6 mice, either exercise increases adult hippocampal neurogenesis to a ceiling value, which is reached by a performance at or below the level achieved by voluntary wheel running, or that a possible positive effect of increased running-wheel activity is balanced by stress resulting from rewarded running, which is no longer performed on a strictly voluntary basis. We suggest that, in C57BL/6 mice, either exercise increases adult hippocampal neurogenesis to a ceiling value, which is reached by a performance at or below the level achieved by voluntary wheel running, or that a possible positive effect of increased is balanced by stress resulting from rewarded running, which is no longer performed on a strictly voluntary basis.

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“…Hippocampal cells are sensitive to stress, and although some positive effects have been reported, numerous studies in many different species provide evidence for a stress-induced reduction in cell proliferation in the dentate gyrus (Gould et al, 1997, Gould et al, 1998, Tanapat et al, 2001, Malberg and Duman, 2003, Brain et al, 2004, Mitra et al, 2006. Social stress also has been shown to cause a reduction in locomotor activity, social motivation and interactions (Blanchard et al, 2001, Denmark et al, 2010, Sandi and Haller, 2015.…”

Section: Effect Of Social Status On Neurogenesismentioning

confidence: 99%

Trading new neurons for status: Adult hippocampal neurogenesis in eusocial Damaraland mole-rats

Oosthuizen

Amrein

2016

Neuroscience

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Highlights• The hippocampal architecture of the Damaraland mole-rat corresponds largely to that of other mole-rat species.• No gender differences are found in hippocampal neurogenesis of Damaraland mole-rats.• Neurogenesis is unrelated to relative age in Damaraland mole-rats.• There is an inverse relationship between social status and neurogenesis in Damaraland mole-rats. 1 AbstractDiversity in social structures, from solitary to eusocial, is a prominent feature of subterranean African mole-rat species. Damaraland mole-rats are eusocial, they live in colonies that are characterized by a reproductive division of labour and a subdivision into castes based on physiology and behaviour. Damaraland mole-rats are exceptionally long lived and reproductive animals show delayed aging compared to non-reproductive animals. In the present study, we described the hippocampal architecture and the rate of hippocampal neurogenesis of wild derived, adult Damaraland mole-rats in relation to sex, relative age and social status or caste. Overall, Damaraland mole-rats were found to have a small hippocampus and low rates of neurogenesis. We found no correlation between neurogenesis and sex or relative age. Social status or caste were the most prominent modulator of neurogenesis. An inverse relationship between neurogenesis and social status was apparent, with queens displaying the lowest neurogenesis while the worker mole-rats had the most. As there is no natural progression from one caste to another, social status within a colony was relatively stable and is reflected in the level of neurogenesis. Our results correspond to those found in the naked mole-rat, and may reflect an evolutionary and environmentally conserved trait within social mole-rat species.

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Social stress-related behavior affects hippocampal cell proliferation in mice

Cited by 84 publications

References 31 publications

Social regulation of adult neurogenesis in a eusocial mammal

Social regulation of adult neurogenesis in a eusocial mammal

A reward increases running-wheel performance without changing cell proliferation, neuronal differentiation or cell death in the dentate gyrus of C57BL/6 mice

Trading new neurons for status: Adult hippocampal neurogenesis in eusocial Damaraland mole-rats

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