Social stress response in adolescents with bipolar disorder

Casement, Melynda D.; Goldstein, Tina R.; Gratzmiller, Sarah M; Franzen, Peter L.

doi:10.1016/j.psyneuen.2018.02.017

Cited by 8 publications

(3 citation statements)

References 68 publications

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“…hypothalamic–pituitary–adrenal [HPA] axis) and autonomic (i.e. heart rate) responses to stress 6,7 . Few studies have investigated the underlying neurobiology that may contribute variation in stress response in bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%

Neural functional connectivity changes to psychosocial stress in young adults with bipolar disorder and preliminary associations with clinical trajectories

et al. 2021

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Background: Stress-related mechanisms are implicated in the pathophysiology of bipolar disorder and may contribute to heterogeneity in illness course. Yet, there is a lack of study investigating the neural mechanisms underlying the stress response in this condition. This study investigated changes in amygdala activation and functional connectivity in response to acute psychosocial stress in young adults with bipolar disorder and explored relations with clinical phenotype and prospective mood symptoms.Methods: 42 young adults [19 with bipolar disorder, age mean ± SD =21.4 ± 2.2 years] completed a modified version of the Montreal Imaging Stress Task. Amygdala activation and functional connectivity with prefrontal cortex (PFC) regions of interest was calculated for control and stress conditions. Main effects of group, condition, and group by condition interaction on amygdala activation and connectivity were modeled. A subset of bipolar participants completed 1-year follow-up assessments.Relations between neural responses to stress with concurrent substance use and prospective mood symptoms were explored.Results: There were no between-group differences in amygdala activation or functional connectivity during the control condition. Increased right amygdala-right rostral PFC (rPFC) functional connectivity to stress was observed in bipolar disorder, compared to typically developing controls. In bipolar disorder, greater increase in right amygdala-right rPFC functional connectivity to stress was associated with less frequent cannabis use, and prospectively with shorter duration and lower severity of depression symptoms over follow-up. Conclusion:Results from this preliminary study suggest differences in frontolimbic functional connectivity responses to stress in young adults with bipolar disorder and associations with cannabis use and prospective mood symptoms.

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Section: Introductionmentioning

confidence: 99%

Neural functional connectivity changes to psychosocial stress in young adults with bipolar disorder and preliminary associations with clinical trajectories

et al. 2021

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“…Different models of HF-HRV are functions used to describe and quantify the pattern of HF-HRV changes over time. Given the typical HF-HRV decrease following a cognitively stressful test (Vazan et al, 2017) the quadratic model has been found to describe brain-regulated HF-HRV acute stress response effectively (Casement et al, 2018; Lin et al, 2017b), and we found it to be superior to other models (see “Results”). This model reflects the U-shape of the HF-HRV response: high at baseline, lower during the task, and rebounded after rest.…”

Section: Methodsmentioning

confidence: 87%

The mediating role of hippocampal networks on stress regulation in amnestic mild cognitive impairment

McDermott

Ren

Lin

2019

Neurobiology of Stress

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Objectives To examine the role of the hippocampus in stress regulation in older adults with amnestic mild cognitive impairment (aMCI). Methods This study combined resting-state functional MRI, structural MRI, self-reported chronic stress exposure, and an electrocardiography-based acute stress protocol to compare aMCI group (n = 17) to their cognitively healthy counterparts (HC, n = 22). Results For the entire sample, there was a positive correlation between chronic stress exposure and acute stress regulation. The aMCI group showed significantly smaller volumes in the right hippocampus than HC. The two groups did not differ in chronic stress exposure or acute stress regulation. In the HC group, the left hippocampal connectivity with inferior parietal lobe was significantly correlated with both the chronic stress and acute stress. In the aMCI group, the left hippocampal connectivity with both the right insula and the left precentral gyrus was significantly correlated to chronic stress exposure and acute stress regulation. Additionally, the left hippocampal connectivity with right insula significantly mediated the relationship between chronic stress exposure and acute stress regulation in aMCI group. Conclusions Extra hippocampal networks may be recruited as compensation to attend the maintenance of relatively normal stress regulation in aMCI by alleviating the detrimental effects of chronic stress exposure on acute stress regulation.

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“…However, only relatively few human studies have simultaneously assessed HPA axis and ANS activity to investigate their direct association [119,120], while most of these studies are conducted in patients [121] or through subjective stress exposure paradigms [122,123].…”

Section: Hpa Axis Influence On Ans Reactivitymentioning

confidence: 99%

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Social stress response in adolescents with bipolar disorder

Cited by 8 publications

References 68 publications

Neural functional connectivity changes to psychosocial stress in young adults with bipolar disorder and preliminary associations with clinical trajectories

Neural functional connectivity changes to psychosocial stress in young adults with bipolar disorder and preliminary associations with clinical trajectories

The mediating role of hippocampal networks on stress regulation in amnestic mild cognitive impairment

The balance within

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