As a tropical climate region in the world, Indonesia has high vulnerable to floods disaster. In West Java, flood is annual disaster that occurs in the eastern region of Cirebon Regency. On 2018, there are thirteen sub-districts in the region have flood up to 2 meters. The study aims to determine the flood hazard and vulnerability in the eastern region of Cirebon Regency. The analysis of flood hazard includes six parameters such as elevation, slope, rainfall, infiltration capacity, distance to river, and surface runoff. Whereas, the flood vulnerability analysis includes parameters of land use, population, and road network. All parameters is analysed using overlay analysis with geographic information system to result the flood hazard and vulnerability model. The results shows the eastern region of Cirebon Regency has flood hazard in very high category reach 22.98 percent, high 33.54 percent, medium 21.80 percent, low 16.60 percent and 5.07 very low percent. Meanwhile, the flood vulnerability map show the cultivation land and built-up land use are most affected by the disaster. The potential number of vulnerable population is very high and high category reach 609,738 peoples who spread in the southeast of region. Whereas, the flood vulnerability to road network reach 3.3 to 6.84 km / km2. The flood hazard occurs in the alluvial plains, floodplains, and back swamps between Cisanggarung and Ciberes watersheds who known as suitable for settlement. Thus, up-land management is sustainable effort to resolve the problem.