The off-grid solar photovoltaic (PV) system is a significant step towards electrification in the remote rural regions, and it is the most convenient and easy to install technology. However, the strategic problem is in identifying the potential of solar energy and the economic viability in particular regions. This study, therefore, addresses this problem by evaluating the solar energy potential and economic viability for the remote rural regions of the Sindh province, Pakistan. The results recommended that the rural regions of Sindh have suitable solar irradiance to generate electricity. An appropriate tilt angle has been computed for the selected rural regions, which significantly enhances the generation capacity of solar energy. Moreover, economic viability has been undertaken in this study and it was revealed that the off-grid solar PV power generation system provides electricity at the cost of Pakistani Rupees (PKR) 6.87/kWh and is regarded as much cheaper than conventional energy sources, i.e., around PKR 20.79/kWh. Besides, the off-grid solar PV power generation system could mitigate maximum CO2 annually on the condition that all of the selected remote rural regions adopt the off-grid solar PV system. Therefore, this study shall help the government to utilize the off-grid solar PV power generation system in the remote rural regions of Pakistan.