Socio-personal factors affecting adherence to treatment in patients with type 2 diabetes: A systematic review and meta-analysis

Shahabi, Nahid; Fakhri, Yadolah; Aghamolaei, Teamur; Hosseini, Zahra; Homayuni, Atefeh

doi:10.1016/j.pcd.2023.03.005

Cited by 5 publications

(4 citation statements)

References 67 publications

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“…Another contributor to clinical outcomes in T2D patients is socioeconomic status. A recent systematic review and meta-analysis evaluated several studies showing that employment can lead to non-adherence to T2D treatment [64]. Thus, gender disparities may have an economic effect in terms of medication adherence and costs.…”

Section: Medication Adherence In Metabolic and Cardiovascular Disease...mentioning

confidence: 99%

Gender-Related Factors in Medication Adherence for Metabolic and Cardiovascular Health

Venditti,

Bleve,

Morano

et al. 2023

Metabolites

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This review explores the impact of gender on medication adherence in the context of metabolic and cardiovascular diseases. Optimal adherence to medication is crucial for achieving treatment goals and preventing adverse outcomes in chronic diseases. The review examines specific conditions such as type 2 diabetes, hypercholesterolemia, arterial hypertension, cardiovascular diseases, and heart failure. In type 2 diabetes, female sex, younger age, new drug prescription, non-white ethnicity, low education level, and low income were identified as predictors of non-adherence. Depressive disorders were also found to influence adherence. In hypercholesterolemia, women exhibited poorer adherence to statin therapy compared to men, with statin-related side effects and patient perception being significant factors. Adherence to anti-hypertensive therapy showed conflicting results, with studies reporting both higher and lower adherence in women. Limited evidence suggests that women may have poorer adherence after acute myocardial infarction and stroke. Regarding heart failure, adherence studies have shown inconsistent findings. The reasons for gender differences in medication adherence are multifactorial and include sociodemographic, disease-related, treatment-related, and psychological factors. This review emphasizes the need for further research to better understand these differences and develop gender-customized interventions that can improve medication adherence and reduce the burden of metabolic and cardiovascular diseases.

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Section: Medication Adherence In Metabolic and Cardiovascular Disease...mentioning

confidence: 99%

Gender-Related Factors in Medication Adherence for Metabolic and Cardiovascular Health

Venditti,

Bleve,

Morano

et al. 2023

Metabolites

View full text Add to dashboard Cite

show abstract

“…2 Type 2 diabetes (T2D) is the most common type of diabetes, afflicting 90−95% patients. 3 Obesity-related T2D is generally associated with reduced mitochondrial activities and insulin secretory function in pancreatic β-cells as well as insulin resistance in other cell types such as hepatocytes, resulting in elevated fasting plasma insulin and blood glucose levels. 4,5 Current clinical treatments for T2D include metformin, which lowers blood glucose levels by inhibiting liver gluconeogenesis and increasing insulin sensitivity through enhanced glucose uptake in the skeletal muscles and in the gut.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, approximately 537 million adults live with diabetes, and the number of diabetic patients is projected to increase to 643 million by 2030 and 783 million by 2045 . Type 2 diabetes (T2D) is the most common type of diabetes, afflicting 90–95% patients . Obesity-related T2D is generally associated with reduced mitochondrial activities and insulin secretory function in pancreatic β-cells as well as insulin resistance in other cell types such as hepatocytes, resulting in elevated fasting plasma insulin and blood glucose levels. , …”

Section: Introductionmentioning

confidence: 99%

Acidic Nanoparticles Restore Lysosomal Acidification and Rescue Metabolic Dysfunction in Pancreatic β-Cells under Lipotoxic Conditions

Lo,

O’Connor,

Loi

et al. 2024

ACS Nano

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Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial impairments. Here, we report a series of biodegradable poly(butylene tetrafluorosuccinate-co-succinate) polyesters, comprising a 1,4-butanediol linker and varying ratios of tetrafluorosuccinic acid (TFSA) and succinic acid as components, to engineer lysosome-acidifying nanoparticles (NPs). The synthesized NPs are spherical with diameters of ≈100 nm and have low polydispersity and good stability. Notably, TFSA NPs, which are composed entirely of TFSA, exhibit the strongest degradation capability and superior acidifying properties. We further reveal significant downregulation of lysosomal vacuolar (H +)-ATPase subunits, which are responsible for maintaining lysosomal acidification, in human T2D pancreatic islets, INS-1 β-cells under chronic lipotoxic conditions, and pancreatic tissues of high-fat-diet (HFD) mice. Treatment with TFSA NPs restores lysosomal acidification, autophagic function, and mitochondrial activity, thereby improving the pancreatic function in INS-1 cells and HFD mice with lipid overload. Importantly, the administration of TFSA NPs to HFD mice reduces insulin resistance and improves glucose clearance. These findings highlight the therapeutic potential of lysosome-acidifying TFSA NPs for T2D.

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“…Currently, approximately 537 million adults live with diabetes, and the total number of diabetic patients is projected to rise to 643 million by 2030 and 783 million by 2045 (2). Type 2 diabetes (T2D) is the most common type of diabetes, afflicting 90-95% of patients (3). Obesity-related T2D generally associates with reduced mitochondrial activities and insulin secretory function in pancreatic β-cells as well as insulin resistance in other cell types such as hepatocytes, resulting in elevated fasting plasma insulin and blood glucose levels (4,5).…”

Section: Introductionmentioning

confidence: 99%

Acidic nanoparticles restore lysosomal acidification and rescue metabolic dysfunction in pancreatic β-cells under lipotoxic condition

Lo,

O’Connor,

Loi

et al. 2023

Preprint

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Type 2 diabetes (T2D) is one of the most common metabolic disorders worldwide without effective treatments. Lysosomal acidification impairment, autophagy defect, and mitochondrial dysfunction all associate with T2D, although the exact pathogenic mechanisms remain under investigation. Here, we report a series of biodegradable poly(butylene tetrafluorosuccinate-co-succinate) (PBFSU) polyesters consisting of an 1,4-butanediol linker and varying ratios of tetrafluorosuccinic acid (TFSA) and succinic acid (SA) as component acids to engineer new lysosome acidifying nanoparticles (NPs). The TFSA component significantly modulates the degradation rate and acidification capability of the PBFSU NPs, where NPs consisting entirely of TFSA, which we termed TFSA NPs, re-acidify impaired lysosomes with the strongest reduction in luminal pH. Further, we show that in both mRNA expression of human T2D pancreatic islets and protein expression in INS-1 β-cells under lipotoxic condition that there is a significant downregulation of genes associated with lysosomal vacuolar (H+)-ATPase (V-ATPase) subunits responsible for maintaining lysosomal acidification. Treatment of TFSA NPs mediates palmitate-induced lipotoxicity in INS-1 β-cells by restoring lysosomal acidification, autophagic function, and mitochondria functions, as well as promoting glucose-stimulated insulin secretion. Administration of TFSA NPs to high-fat diet T2D mice improves glucose clearance and reduces insulin resistance. Together, the data document the therapeutic potential of lysosome acidifying TFSA NPs for T2D.

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Socio-personal factors affecting adherence to treatment in patients with type 2 diabetes: A systematic review and meta-analysis

Cited by 5 publications

References 67 publications

Gender-Related Factors in Medication Adherence for Metabolic and Cardiovascular Health

Gender-Related Factors in Medication Adherence for Metabolic and Cardiovascular Health

Acidic Nanoparticles Restore Lysosomal Acidification and Rescue Metabolic Dysfunction in Pancreatic β-Cells under Lipotoxic Conditions

Acidic nanoparticles restore lysosomal acidification and rescue metabolic dysfunction in pancreatic β-cells under lipotoxic condition

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