Sociodemographic characteristics and chronic medical conditions as risk factors for herpes zoster

Esteban-Vasallo, María D.; Domínguez‐Berjón, M. Felícitas; Gil-Prieto, Ruth; Astray‐Mochales, Jenaro; Miguel, Ángel Gil de

doi:10.4161/hv.28620

Cited by 64 publications

(63 citation statements)

References 55 publications

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“…25 Recent studies conducted in Spain and England characterized adult patients with zoster without a priori hypothesis and showed that asthma was one of the conditions associated with an increased risk of zoster. 47,48 In addition, previous studies showed increased risks of herpes simplex ocular infections 49,50 and eczema herpeticum 51 among patients with atopic conditions.…”

Section: Discussionmentioning

confidence: 98%

Asthma as a risk factor for zoster in adults: A population-based case-control study

Kwon

Bang

Kim

et al. 2016

Journal of Allergy and Clinical Immunology

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BACKGROUND We recently reported an increased risk of herpes zoster (shingles or zoster) in children with asthma, but little is known about whether it is true for adults with asthma. We determined whether asthma is associated with an increased risk of zoster in adults. METHODS This study was designed as a population-based case-control study. Zoster cases during the study period were identified among adults (aged ≥ 50 years) who resided in Olmsted County, Minnesota. We compared the frequency of asthma between zoster cases and birthday- and gender-matched controls (1:2 matching) without a history of zoster. Asthma status was ascertained by predetermined criteria. Conditional logistic regression model was used to assess the association of asthma with risk of zoster. RESULTS A total of 371 zoster cases and their 742 matched controls were enrolled. Of the 371 cases, 246 (66%) were females, 348 cases (94%) were Caucasians, and the mean (± standard deviation) age was 66.8±10.7 years. Twenty-three percent (N=87) of zoster cases had a history of asthma, compared to 15% (N=114) in controls. Controlling for pertinent covariates and confounders, there was a significant association between a history of asthma and risk of zoster (adjusted odds ratio: 1.70, 95% CI: 1.20–2.42, p=0.003). Population-attributable risk percent for asthma was about 10%. CONCLUSIONS Asthma is an unrecognized risk factor for zoster in adults. Consideration for immunizing adults with asthma aged over 50 years as a target group should be given.

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Section: Discussionmentioning

confidence: 98%

Asthma as a risk factor for zoster in adults: A population-based case-control study

Kwon

Bang

Kim

et al. 2016

Journal of Allergy and Clinical Immunology

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“…35 This study finding was corroborated by the two recent studies that indicated associations of asthma with the increased risk of HZ. 36,37 The mechanisms that underlie the potential associate between asthma and HZ are unknown. The recent review article on the increased risk of microbial infections associated with asthma covered the potential mechanisms that underlie the relationship between asthma and the increased risk of common and serious microbial infections.…”

Section: Discussionmentioning

confidence: 99%

Risk of herpes zoster in children with asthma

Wi¹,

Kim²,

Mehra³

et al. 2015

allergy asthma proc

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“…The underlying theory of these articles states that both adaptive and innate immunity may be compromised in asthmatics, creating a favorable environment for reactivation of HZ. This theory improves evidence that there is complex interactions between atopic disease states and innate/adaptive infectious immunity [58][59][60] . Adding to the complexity is evidence showing that pediatric asthmatics treated with steroids are at increased risk of severe disease from wild-type VZV infection 61 .…”

Section: A C C E P T E Dmentioning

confidence: 64%

The Cost–effectiveness of Varicella Zoster Virus Vaccination Considering Late Onset Asthma

Ditkowsky

Kohlhoff²,

Smith‐Norowitz³

2016

Pediatric Infectious Disease Journal

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VZV vaccination program was less costly than the "no-vaccination" scenario, despite delayed onset of asthma post VZV infection. However, vaccination resulted in increased asthma morbidity and mortality. This adds to current evidence that VZV vaccination is cost-effective, and may alter asthma-related health-care outcomes. VZV's effect on asthma symptoms still needs further evaluation before firm conclusions can be reached.

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Sociodemographic characteristics and chronic medical conditions as risk factors for herpes zoster

Cited by 64 publications

References 55 publications

Asthma as a risk factor for zoster in adults: A population-based case-control study

Asthma as a risk factor for zoster in adults: A population-based case-control study

Risk of herpes zoster in children with asthma

The Cost–effectiveness of Varicella Zoster Virus Vaccination Considering Late Onset Asthma

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