Sociodemographic characteristics, sexual behaviour and knowledge about cervical cancer prevention as risk factors for high-risk human papillomavirus infection in Arkhangelsk, North-West Russia

Roik, Elena; Sharashova, Ekaterina; Kharkova, O A; Nieboer, Evert; Postoev, Vitaly Alexandrovich; Odland, Jon Øyvind

doi:10.1080/22423982.2018.1498681

Cited by 13 publications

(7 citation statements)

References 45 publications

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“…Younger women had an HPV infection most frequently. Our data correspond to the results of other studies, according to which the peak of HPV detection occurs in age groups of women younger than 30 years old who have the highest sexual activity and change of sexual partners (Zeng et al, 2016;Roik et al, 2018). In the United States population, the prevalence range of HPV positive was in young women under 30 years old, between 41-51% (Karuri et al, 2017).…”

Section: Discussionsupporting

confidence: 90%

Genotype Distribution and Prevalence of Human Papillomavirus Among Russian Women in Rostov, Southern Federal District of Russia

2021

JJBS

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HPV burden is a marker for cervical neoplasms and cancer. Prevalence of HPV infection and HPV genotypes varies amongst different regions. This research was aimed to investigate the age distribution patterns and prevalence of high-risk HPV genotypes among Rostov-on-Don women. Scrapings of epithelial cells obtained from the urogenital tract of 5655 women. Total DNA was extracted by the sorbent method; Real-Time PCR was used to investigate the HPV load and HPV genotyping. HPV was found in 40% of the DNA samples. The HPV infection was most prevalent among women age ≤ 20 years (55,26%) compared to 27,34% of women older than 40 years (p = 0,001). The prevalence of HPV 16/18 types was almost the same in all age groups. More 50% of women with a high HPV load were women at age group 20-30 years old. Among 254 women, 79,13% had single HPV type infection, and 20,86% had multiple HPV infection. The most frequent of high-risk HPV types were 16, 51 and 31 types. The most common variant of genotypes co-exist for multiple HPV infections were genotypes of A7 + A9 phylogenetic groups (30,18 %). Multiple HPV infections were the most prevalent (67,92%) in women at age group 20-30 years old. We concluded the prevalence of HPV infection among younger women was the highest and declined gradually with age among Rostov-on-Don women.

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Section: Discussionsupporting

confidence: 90%

Genotype Distribution and Prevalence of Human Papillomavirus Among Russian Women in Rostov, Southern Federal District of Russia

2021

JJBS

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“…No fixed pattern of the HPV genotypes distribution observed even in different parts of a province, e,g, the samples from suburb of Tehran commonly demonstrated mixed infections (the data were not shown). Although no sociodemographic data are available, low education and inappropriate economic conditions may be an explanation, high risk HPV distribution is affected by sexual behavior, host immune factors, environmental factors, smoking, having multiple sex partners, and the presence of other sexually transmitted infections (16). Therefore, HPV as an important transmitted infection causes some critical HPV-associated cancers in human, circulating HPV genotypes should be available to plan better the prevention.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of HPV Genotypes in Iranian Population: An Update

Kesheh

2019

Iran J Pathol

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Background & Objective: Human papillomavirus (HPV) is the main cause of genital warts and some anogenital cancers in male and female subjects which is commonly transmitted by sexual contacts. The objective of this cross-sectional study was to examine the prevalence of HPV genotypes in 10,266 Iranian male and female population, according to their age. Methods:Samples were collected from the penile and anal sites of male subjects and the vagina and cervix of female subjects in a time period between 2011 and 2016. HPV DNA was detected in PCR using the MY09 and MY11 primers, and the INNO-LiPA assay was applied for HPV genotyping. To investigate the relevance of HPV infection and age, the samples were classified into 4 age groups (13-29, 30-44, 45-59, and 60-74).Results:Totally, the most common low risk HPV genotypes detected in the studied male and female subjects were HPV-6 (77.7% and 43.3%) and HPV-11 (13.7% and 11.4%), and more frequent high risk HPV genotypes were HPV-16 (5.5% and 16.6%) and HPV-52 (3.2% and 9.6%), respectively. High burden of the HPV infection was observed at ranges of 30 and 44 years (51.8%) with a peak at ranges between 30 and 32 years. No considerable statistically significant correlation was found between HPV infection and age (P=1).Conclusion:This study gave an epidemiological overview of circulating HPV genotypes in Iranian population to develop future vaccination policies, though the findings of prevalent HPV genotypes in female subjects were inconsistent with the previous studies reported in Iran.

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“…Most cases of cervical cancer are caused by HPV infection ( 48 ). Although surgical treatment, chemotherapy and radiotherapy have a therapeutic effect on cervical cancer, this effect is insufficient ( 49 ). Recent studies have reported that lncRNAs play important regulatory roles in cervical cancer ( 50 – 52 ).…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA UCA1 enhances cervical cancer cell proliferation and invasion by regulating microRNA‑299‑3p expression

Xing

Chen

2021

Oncol Lett

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The long non-coding RNA, urothelial cancer-associated 1 (UCA1) is an important regulator in several tumors. However, to the best of our knowledge, the clinical roles of UCA1 in cervical cancer remain unclear. Thus, the present study aimed to investigate the function and mechanism of UCA1 in cervical cancer. Reverse transcription-quantitative PCR analysis was performed to detect UCA1 and microRNA (miR)-299-3p expression in cervical cancer tissues and cell lines. The Cell Counting Kit-8 and Transwell assays were performed to assess cell proliferation and invasion, respectively. Furthermore, the dual-luciferase reporter assay was performed to confirm the association between UCA1 and miR-299-3p. Rescue experiments were performed to determine the mechanism of the UCA1/miR-299-3p axis. The results demonstrated that UCA1 expression was upregulated in cervical cancer tissues and cell lines. Furthermore, overexpression of UCA1 enhanced the proliferation and invasion of cervical cancer cells, the effects of which were reversed following UCA1 knockdown. Notably, UCA1 interacted with miR-299-3p and negatively regulated miR-299-3p expression. In addition, miR-299-3p expression was downregulated in cervical cancer tissues and cell lines. Overexpression of miR-299-3p suppressed the proliferation and invasion of cervical cancer cells, reversing the effects of UCA1 knockdown on cervical cancer cell proliferation. Taken together, the results of the present study suggest that UCA1 promotes cell proliferation and invasion by regulating miR-299-3p expression in cervical cancer.

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Sociodemographic characteristics, sexual behaviour and knowledge about cervical cancer prevention as risk factors for high-risk human papillomavirus infection in Arkhangelsk, North-West Russia

Cited by 13 publications

References 45 publications

Genotype Distribution and Prevalence of Human Papillomavirus Among Russian Women in Rostov, Southern Federal District of Russia

Genotype Distribution and Prevalence of Human Papillomavirus Among Russian Women in Rostov, Southern Federal District of Russia

The Prevalence of HPV Genotypes in Iranian Population: An Update

Long non‑coding RNA UCA1 enhances cervical cancer cell proliferation and invasion by regulating microRNA‑299‑3p expression

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