Socioeconomic differences in hyperuricemia and gout: a systematic review and meta-analysis

Pan, Zhe; Huang, Mingkai; Fang, Ming; Xie, Xiang; Huang, Ze

doi:10.1007/s12020-020-02281-w

Cited by 16 publications

(19 citation statements)

References 33 publications

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“…These results provide a research direction for further studies exploring the association between sleep and uric acid to clarify their relationship. Finally, socioeconomic status [ 75 ] and dietary habits were not examined in this study.…”

Section: Discussionmentioning

confidence: 99%

Association of sleep quality and sleep duration with serum uric acid levels in adults

Chou

Shen

et al. 2020

PLoS ONE

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Objective To date, the association between sleep duration or sleep quality and hyperuricemia has remained unclear. In addition, sleep duration and quality were not considered concomitantly in previous studies. Thus, this study was aimed toward an examination of the association of sleep duration and quality with uric acid level in a Taiwanese population. Methods A total of 4,555 patients aged ≥18 years were enrolled in this study. The sleep duration was classified into three groups: short (<7 h), normal (7–9 h), and long (≥9 h). The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, and poor sleep quality was defined as a global PSQI score of >5. Results Poor sleepers were younger and had lower body mass index, blood pressure, uric acid, blood sugar, cholesterol, creatinine level, shorter sleep duration, and engaged in less exercise but had a higher white blood cell count and prevalence of smoking as compared to good sleepers. There were also differences in body mass index, blood pressure, uric acid, blood sugar, lipid profiles, and sleep quality among subjects with different sleep durations. After adjusting for other variables, poor sleep quality was associated with lower uric acid levels. In addition, short sleep duration was positively associated with higher uric acid levels. Conclusions Poor sleep quality was related to lower uric acid levels, whereas short sleep duration was associated with higher uric acid levels.

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Section: Discussionmentioning

confidence: 99%

Association of sleep quality and sleep duration with serum uric acid levels in adults

Chou

Shen

et al. 2020

PLoS ONE

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“…In this cross-sectional study, we analyzed the association between hyperuricemia and tea intake using data from the health examinee database at Nanfang Hospital and found that higher tea consumption was associated with a greater risk of hyperuricemia. This association remained after adjustment for potential confounders, including age, sex, BMI, educational level, smoking status, alcohol consumption, intake of barbecue or fried food, intake of corned or smoked food, salty diet, overeating, dining out, midnight snacking, and biochemical indices (SCr, CHOL, TG, LDL-C, HDL-C and FBG, identified by univariate regression analysis and in the published literature 13 , 27–33 ). These adjustments did not change the results, suggesting that tea consumption is an independent risk factor for hyperuricemia.…”

Section: Discussionmentioning

confidence: 88%

“…There have been reports indicating an association between the risk of hyperuricemia and SCr, CHOL, TG, LDL-C, HDL-C, and FBG levels. 13 , 27–33 The first model was adjusted for age, sex, and BMI. The second model was further adjusted for SCr (μmol/L), CHOL (mmol/L), TG (mmol/L), LDL-C (mmol/L), HDL-C (mmol/L), FBG (mmol/L), and hypertension.…”

Section: Methodsmentioning

confidence: 99%

Tea Consumption is Associated with an Increased Risk of Hyperuricemia in an Occupational Population in Guangdong, China

Zhou

et al. 2022

IJGM

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Purpose Chronic hyperuricemia leads to long-term deposition of monosodium urate crystals that may damage the joint structure and affect quality of life. Although hyperuricemia prevalence varies, most studies indicate increased cases of hyperuricemia worldwide. The relationship between hyperuricemia and tea consumption is uncertain. This cross-sectional study investigated the effect of tea consumption on the risk of hyperuricemia in the working population in Guangdong, China. Patients and Methods Data on weight, height, blood pressure, laboratory test results, and health questionnaire responses of 7644 adults aged ≥18 years were obtained from the health examinee dataset of Nanfang Hospital. The characteristics of subjects with and without hyperuricemia were compared using t -tests or non-parametric Mann–Whitney U -tests for continuous variables and chi-square tests for categorical variables. Relationships between hyperuricemia and participant characteristics (sex, age, education level, smoking history, alcohol consumption, hypertension, body mass index, tea consumption, and other dietary factors) were examined using univariate and multivariate logistic regression models to identify independent risk factors for hyperuricemia. Results Tea consumption was associated with a higher risk of hyperuricemia in the crude model (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.48–2.05, once a month through twice a week vs never, P <0.001; OR 2.44, 95% CI 2.07–2.89, ≥3 times a week vs never, P <0.001). The adjusted OR for hyperuricemia was 1.30 (95% CI 1.08–1.56, P =0.006) in participants who consumed tea once a month through twice a week and 1.35 (95% CI 1.11–1.64, P =0.003) in those who consumed tea ≥3 times a week compared with the “never” reference group after adjusting for sociodemographic factors, anthropometric and biochemical indices, and dietary factors. This relationship remained significant in men but not women in subgroup analysis. Conclusion Tea consumption is an independent risk factor for hyperuricemia and is more pronounced in men than women.

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“…It was suggested that UA which is capable of increasing the plasma antioxidant capacity (28) can promote defensive mechanisms against lipid peroxidation in the brain and promote some neuroprotective effects. However, UA also harbors prooxidant effects as it stimulates hydrogen peroxide production.…”

Section: Discussionmentioning

confidence: 99%

“…In the second regression, the score (product of sum of response and sum of mistakes) of the reaction time test was the dependent variable and categorized UA was the independent variable. Based on evidence from previous studies we adjusted both regressions for age [23,24], BMI [25,26], gender, and education [27,28].…”

Section: Methodsmentioning

confidence: 99%

High serum uric acid levels are associated with worse cognitive performance: A cross-sectional study

Khaled

Abdelhamid

Al-Mazroey

et al. 2022

Preprint

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Introduction: The association between raised serum uric acid and cognitive dysfunction remains a debated issue. In the present study, we investigated whether serum uric acid is associated with cognitive performance in a cohort of healthy individuals in Qatar. Methods: We conducted a cross-sectional study on a cohort of individuals aged 40 to 80 years old, without a diagnosis of dementia, schizophrenia, and stroke, who participated in Qatar Biobank. Cognitive performance was assessed using the CANTAB s paired episodic memory test and reaction time test. The participants were divided into two groups, one group with a normal serum uric acid level (<350 μmol/l) and the other with high serum uric acid levels (>350 μmol/l). Two multivariable linear regression models were applied to determine the association between serum uric acid and memory test performance score and between serum uric acid and reaction time test performance score. Results: A total of 996 individuals with median age 48.0 years, IQR: (44.5, 54.0), of which 48.2% were male, were included. After adjusted multivariable linear regression, high serum uric acid levels were strongly associated with poor performance in the paired episodic memory test (beta -6.25, 95%CI -10.65 to -1.84, p= 0.006). However, after adjusted multivariable linear regression, we found no significant association between high serum uric acid and performance in the reaction time test (beta -13.24, 95%CI -138.77 to 112.29, p= 0.836). Discussion/ Conclusion: In a cohort of healthy individuals in Qatar, high serum uric acid levels are associated with worse performance in visual memory and new learning domains of cognitive function but no significant effect on processing speed function.

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Socioeconomic differences in hyperuricemia and gout: a systematic review and meta-analysis

Cited by 16 publications

References 33 publications

Association of sleep quality and sleep duration with serum uric acid levels in adults

Association of sleep quality and sleep duration with serum uric acid levels in adults

Tea Consumption is Associated with an Increased Risk of Hyperuricemia in an Occupational Population in Guangdong, China

High serum uric acid levels are associated with worse cognitive performance: A cross-sectional study

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