Socioeconomic Factors and Severity of Coronary Artery Disease in Patients Undergoing Coronary Angiography: A Multicentre Study of Arabian Gulf States

Daoulah, Amin; Elkhateeb, Osama; Nasseri, S. Ali; Al-Murayeh, Mushabab; Alkaabi, Salem; Lotfi, Amir; Alama, Mohamed Nabil; Al-Faifi, Salem M.; Haddara, Mamdouh; Dixon, Ciaran M.; Alzahrani, Ibrahim; Alghamdi, Abdullah A.; Ahmed, Waqas; Fathey, Adnan; Haq, Ejazul; Alsheikh‐Ali, Alawi A.

doi:10.2174/1874192401711010047

Cited by 11 publications

(9 citation statements)

References 71 publications

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“…On the other hand, unemployment and low income levels, socioeconomic factors associated with coronary artery disease, were higher in divorced women. Multiple interrelated socioeconomic factors, such as unemployment, low income, and divorce status may produce a risk of severe coronary artery disease that meets or exceeds that of traditional risk factors such as diabetes [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Divorce and Severity of Coronary Artery Disease: A Multicenter Study

Daoulah

Al-Murayeh

Alkaabi

et al. 2017

Cardiology Research and Practice

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The association between marital status and coronary artery disease (CAD) is supported by numerous epidemiological studies. While divorce may have an adverse effect on cardiac outcomes, the relationship between divorce and severe CAD is unclear. We conducted a multicenter, observational study of consecutive patients undergoing coronary angiography during the period between April 1, 2013, and March 30, 2014. Of 1,068 patients, 124 (12%) were divorced. Divorce was more frequent among women (27%) compared to men (6%). Most divorced patients had been divorced only once (49%), but a subset had been divorced 2 (38%) or ≥3 (12%) times. After adjusting for baseline differences, there was no significant association between divorce and severe CAD in men. In women, there was a significant adjusted association between divorce and severe MVD (OR 2.31 [1.16, 4.59]) or LMD (OR 5.91 [2.19, 15.99]). The modification of the association between divorce and severe CAD by gender was statistically significant for severe LMD (Pinteraction 0.0008) and marginally significant for CAD (Pinteraction 0.05). Among women, there was a significant adjusted association between number of divorces and severe CAD (OR 2.4 [95% CI 1.2, 4.5]), MVD (OR 2.0 [95% CI 1.4, 3.0]), and LMD (OR 3.4 [95% CI 1.9, 5.9]). In conclusion, divorce, particularly multiple divorces, is associated with severe CAD, MVD, and LMD in women but not in men.

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Section: Discussionmentioning

confidence: 99%

Divorce and Severity of Coronary Artery Disease: A Multicenter Study

Daoulah

Al-Murayeh

Alkaabi

et al. 2017

Cardiology Research and Practice

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“…Для сравнения оценены литературные данные о распространенности генотипов CYP2C19 (*2, *3 и *17 аллели) у здоровых добровольцев бурятской национальности [8]. В будущем планируется группа сравнительного контроля для оценки частоты носительства полиморфных вариантов у русских пациентов с ОКС, проживающих в Улан-Удэ.…”

Section: ограниченияunclassified

Association between genetic determinants of clopidogel metabolism and clinical cardiovascular risk indicators in Buryat patients

Zelenskaya¹,

Донирова²,

Altayev³

et al. 2019

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Background. In some patients, the metabolism of clopidogrel is altered because of the presence of polymorphic variants rs4244285 (* 2), rs4986893 (* 3) and rs12248560 (* 17) in the CYP2C19 gene. There is also evidence of decreased efficacy of clopidogrel in individuals with the T/T genotype in the variant rs2305948 of the VEGFR-2 gene. Nevertheless, this medication is used widely in Russia due to the availability of generic anticoagulants.Aim. To assess the prevalence of the following polymorphic variants of CYP2C19: rs4244285 (* 2), rs4986893 (* 3) and rs12248560 (* 17); assess the prevalence of the rs2305948 variant of VEGFR-2, and determine cardiovascular risk factors in patients of Buryat nationality.Methods. The study included 113 patients of Buryat nationality who underwent coronary stent placement due to acute coronary syndrome. Patients were stratified by the presence of the following alleles: CYP2C19 * 2, *3, *17 and VEGFR-2 rs2305948. The following laboratory parameters were measured for all patients: blood glucose, lipid spectrum, creatinine, and glomerular filtration rate. The severity of coronary atherosclerosis was evaluated.Results. The frequencies of the alleles and halotypes (CYP2C19 * 2, * 3 and *17) were determined. An association between the carriage of the C/C genotype in rs2305948 and a <60 ml/min/1.73 m2 decrease in glomerular filtration rate (χ2 = 4.185, p = 0.032) were found. Additionally, the C/C genotype in rs2305948 was associated with higher blood pressure (χ2 = 12.593, p = 0.001). For men, we identified a positive correlation between the rs2305948 C/C allele and the number of significant coronary stenoses (R = 0.227, p < 0.05).Conclusion. Among Buryat patients with acute coronary syndrome and percutaneous coronary intervention, the CYP2C19*2,*3 polymorphic variants were associated with a 46.0% decrease in the metabolic rate for clopidogrel. Furthermore, we identified several associations between the C/C genotype in the rs2305948 variant of VEGFR-2 with a number of cardiovascular risk factors.Received 2 September 2019. Revised 24 October 2019. Accepted 30 October 2019.Funding: The study did not have sponsorship.Conflict of interest: Authors declare no conflict of interest.Author contributionsConception and study design: V.D. Altayev, K.V. Protasov, G.I. LifshitsData collection and analysis: Е.М. Zelenskaya, K.Y. Nikolaev, O.S. Donirova, V.D. Altayev, K.V. Protasov, E.N. Voronina, G.I. LifshitsDrafting the article: Е.М. ZelenskayaCritical revision of the article: Е.М. ZelenskayaFinal approval of the version to be published: Е.М. Zelenskaya, K.Y. Nikolaev, O.S. Donirova, V.D. Altayev, K.V. Protasov, E.N. Voronina, G.I. Lifshits

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“…Всем пациентам проведена коронарография и эхокардиография. Поражение ствола левой коронарной артерии (ЛКА) не менее 50%, а также поражение проксимального или среднего участка трех основных артерий (ПТА) более 70%, или стеноз ствола ЛКА более 50% расце-нивались как проявления тяжелого коронарного ате-росклероза [5]. Кроме этого, определялось наличие бифуркационного стеноза КА и наличие стенозов не менее 70% в не менее чем в трех КА.…”

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