This study investigates the relationship between O and H isotopes in samples of Mexican hairand drinking water. The purpose of this study was twofold. First, we wanted to quantify the relationship between isotopes in Mexican hair and tap water to understand the impact of water stress and differing socioeconomic status on accurate predictions of drinking water. Second, we wanted to determine whether currently existing semi mechanistic models could accurately represent the relationship between hair and tap water. For this study, we used a subset of paired (N = 62) human hair and (N = 76) tap water samples. Isotope values in tap water spanned a range from -11.4 ‰ to -4.3 ‰ and -79.1 ‰ to -22.5 ‰ for δ 18 O and δ 2 H, respectively. Isotope values in hair ranged from +9.5 ‰ to +16.1 ‰ and -90.8 ‰ to -53.7 ‰ for δ 18 O and δ 2 H, respectively.The most depleted δ 18 O and δ 2 H hair values came from individuals in the state of Morelos. For our modern Mexican population, positive correlations between isotopes in hair and water were not significant, with correlation coefficients of r = 0.61 (p = 0.05) and r = 0.60 (p = 0.06) for 18 O and 2 H respectively. Error-in-variables regression yielded linear fits that were somewhat better for 2 H relative to 18 O: δ 18 Oh = 0.183 [± 0.132] δ 18 Otw + 15.7 [± 0.9] ‰ (r 2 = 0.23); δ 2 Hh = 0.181 [± 0.076] δ 2 Htw -64.0 [± 3.0] ‰ (r 2 = 0.34). In short, data from this Mexican population do not exhibit the strong relationships between isotope values of 18 O and 2 H in tap water and hair that have been characteristic of other populations studied to date. Given the economic stratification of this region and the poor correlation between hair and water samples, we chose to consider the possibility that lthe fraction of the diet derived from local sources -and fsthe fraction of nonexchangeable H in keratin that was fixed in vivo-are local, rather than global, parameters for this population. We estimated a different value of l and fs for each location. Given the anticipated importance of the non-local dietary contribution, we treated the isotopic content of non-local