Socioeconomic status. The relationship with health and autoimmune diseases

Calixto, Omar-Javier; Anaya, Juan Manuel

doi:10.1016/j.autrev.2013.12.002

Cited by 123 publications

(100 citation statements)

References 232 publications

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“…12 With greater understanding of the interaction between pregnancy and SLE, as well as cooperation among physicians who provide care for such patients, the maternal and infant prognosis has greatly improved. 13,14 However, some patients still have a poor prognosis, or even die of worsening SLE.…”

Section: Discussionmentioning

confidence: 99%

Prognosis in Pregnant Females With Systemic Lupus Erythematosus

Liu

Zhou

2017

Arch Rheumatol

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Objectives:This study aims to analyze the relationship between pregnancy and lupus, and explore the risk factors that adversely affect maternal and infant outcomes. Patients and methods:The pregnancy outcomes in 112 pregnant females (mean age 24.3±2.8 years; range 20 to 35 years) with systemic lupus erythematosus (SLE) were retrospectively analyzed. Pregnancy outcomes before and after pregnancy were compared, and the associations with lupus nephritis, positive anti-Ro/SSA antibody, positive La/SSB antibody, complement 3 and complement 4, high blood pressure, positive anticardiolipin (aCL) antibody, Raynaud's phenomenon, and lupus recurrence were evaluated. Factors contributing to adverse outcomes were analyzed using multinomial logistic regression. Results: The live birth rate in females diagnosed with SLE before a pregnancy was higher than that in females diagnosed with SLE after a pregnancy. The fetal mortality rate in females diagnosed with SLE after a pregnancy was higher than that in females diagnosed with SLE before a pregnancy. However, the abortion rate in females diagnosed with SLE before a pregnancy was also significantly higher than that in females diagnosed with SLE after a pregnancy. The incidence of preterm birth in females diagnosed with SLE after a pregnancy was higher than that in females diagnosed with SLE after a pregnancy. Preterm birth was more likely to occur in females positive for Ro/SSA antibody. Patients with hypertension and Raynaud's phenomenon had a higher risk of intrauterine growth retardation. In addition, the presence of aCL antibody was associated with pregnancy loss. Multinomial logistic regression analysis showed that many factors might be associated with adverse pregnancy outcomes, including lupus nephritis, positive Ro/SSA antibody, positive La/SSB antibody, complement 3 and complement 4, positive aCL antibody, lupus recurrence, hypertension, and Raynaud's phenomenon. Conclusion: Lupus nephritis, Ro/SSA antibody, aCL antibody, hypertension, Raynaud's phenomenon, and lupus recurrence are important factors associated with adverse pregnancy outcomes.

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Section: Discussionmentioning

confidence: 99%

Prognosis in Pregnant Females With Systemic Lupus Erythematosus

Liu

Zhou

2017

Arch Rheumatol

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“…Social inequity plays an important role in the prevalence of chronic diseases [1,2], but information related to rheumatic diseases is still scarce [3,4]. Few studies have identified the existence of inequities among patients with rheumatoid arthritis (RA) [4], osteoarthritis (OA) [5], and systemic lupus erythematosus [6] in any country.…”

Section: Introductionmentioning

confidence: 99%

The Social Gap Index and the prevalence of osteoarthritis in the community: a cross-sectional multilevel study in Mexico

et al. 2014

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Multilevel studies have gained importance for highlighting social inequalities in health. These associations have been reported previously in diseases such as arthritis and chronic pain. We conducted a cross-sectional study using multilevel analysis to identify individual and contextual factors associated with the variation of prevalence of osteoarthritis (OA) in the Mexican population. The sample included 17,566 individuals of which 10,666 (60.7%) were women. The relationship between individual and contextual factors and OA were analyzed with a multilevel strategy. From the total population, 1,681 individuals had OA. Multilevel analysis showed that individual variables such as female gender (odds ratio (OR) = 1.3, 95% confidence interval (CI) 1.1, 1.4), age range 55-65 years (OR = 1.6, 95% CI 1.3, 2.0), musculoskeletal pain in the last 7 days (OR = 2.6, 95% CI 2.3, 3.0), and use of pain treatments (OR = 1.4, 95% CI 1.2, 1.7) were associated with OA. At the regional level, the Social Gap Index (SGIx) was associated with the diagnosis of OA (coefficient 0.5, 95% CI 0.2-1.1). The SGIx contextual variable was positively associated with the regional prevalence of OA and the variation in prevalence of OA in different regions. The larger the social gap, the greater the variation in OA prevalence. These factors were independently associated with the prevalence of OA: female gender, pain intensity, physical limitation, and the use of pain treatments were individual variables associated with OA. The association between OA prevalence and regional variations with SGIx reflects inequities in health provisions that should be considered in health programs.

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“…RA has traditionally been associated with a substantial burden of disease, loss of work productivity and increased mortality [1][2][3]. The pathophysiology of RA is not completely understood and no single test exists to confirm the diagnosis [4].…”

Section: Introductionmentioning

confidence: 99%

Predictive value of anti-citrullinated peptide antibodies: a real life experience

et al. 2014

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Rheumatoid Arthritis (RA) is an autoimmune destructive joint disease, characterized by the presence of rheumatoid factor and anti-citrullinated peptide antibodies. Anti-citrullinated peptide antibodies were recently defined as RA criterion with sensitivity and specificity of 50-80 and 75-95 %, respectively. However, in the general population, the predictive value of anti-citrullinated peptide antibodies is yet to be determined. Herein, we aim to determine the predictive value of anti-citrullinated peptide antibodies in real life as well as clinical and serological factors related to this value. Retrospective cross-sectional study of consecutive samples evaluated for anti-citrullinated peptide antibodies in a referral autoimmune laboratory. Demographic and clinical parameters at the time the sample was drawn were collected. During November 2011 through December 2013, a total of 215 anti-citrullinated peptide antibody tests were performed in our laboratory. Data were available for 140 samples of which only 28 samples were positive for anti-citrullinated peptide antibodies. Of the 140 patients tested, 18 were diagnosed with RA, of which 12 were positive and 6 were negative for anti-citrullinated peptide antibody test. Thus, in this cohort, anti-citrullinated peptide antibodies were positive in 20 % of samples with a positive predictive value (PPV) of 43 % and a negative predictive value of 95 %. In real life, only 20 % of anti-citrullinated peptide antibody tests referred to a tertiary center where found to be positive. The negative predictive value of this test is very high and may support the common use of anti-citrullinated peptide antibody test as an exclusion criterion in the process of evaluating a patient with rheumatic disease.

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Socioeconomic status. The relationship with health and autoimmune diseases

Cited by 123 publications

References 232 publications

Prognosis in Pregnant Females With Systemic Lupus Erythematosus

Prognosis in Pregnant Females With Systemic Lupus Erythematosus

The Social Gap Index and the prevalence of osteoarthritis in the community: a cross-sectional multilevel study in Mexico

Predictive value of anti-citrullinated peptide antibodies: a real life experience

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