Sodium [1‐<sup>11</sup>C]‐butyrate — new diagnostic agent for pet

Fadeev, N. P.; Tyutin, L. A.; Kostenikov, N. A.; Ryjkova, D. V.; Soukhov, V. Yu.; Savello, V. E.; Mostova, M. I.; Bruskin, Alexander; Pavlenko, K. S.

doi:10.1002/jlcr.25804401109

Cited by 2 publications

(2 citation statements)

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“…[ 11 C]Butyrate was iv injected in fasted patients demonstrating fast elimination in myocardial segments with normal oxidative metabolism, whereas, in the ischemic region, an increased uptake was registered after 23–30 min. Furthermore, it allowed visualizing myocardial viability in several dysfunctional segments in the presence of oxidative events . Furthermore, [ 11 C]butyrate iv injected in 24 postoperative patients with brain tumors (15 male and 9 female, mean age 41 ± 12 years) has allowed detection and differential diagnosis of benign and malignant brain tumors and monitoring efficacy of therapy .…”

Section: Fatty Acidsmentioning

confidence: 99%

“…Furthermore, it allowed visualizing myocardial viability in several dysfunctional segments in the presence of oxidative events . Furthermore, [ 11 C]butyrate iv injected in 24 postoperative patients with brain tumors (15 male and 9 female, mean age 41 ± 12 years) has allowed detection and differential diagnosis of benign and malignant brain tumors and monitoring efficacy of therapy . Lastly, a study in 27 patients (18 male and 9 female, mean age 41 ± 14 years) has resulted in a significant uptake in adenocarcinomas while benign lesions and chronic pancreatitis demonstrated significantly decreased uptake …”

Section: Fatty Acidsmentioning

confidence: 99%

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Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds

et al. 2022

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The presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development using the short-lived radionuclides carbon-11. In the last few decades, methodological improvements and fully automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons with the radionuclide has provided important information on the biochemistry of the authentic compounds and increased the understanding of their in vivo behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on their radiochemistry methodologies and preclinical and clinical studies in healthy subjects.

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Section: Fatty Acidsmentioning

confidence: 99%

Section: Fatty Acidsmentioning

confidence: 99%