Sodium 18F-Fluoride PET/CT of Bone, Joint, and Other Disorders

Abstract

The use of 18F-sodium fluoride (18F-NaF) with positron emission tomography-computed tomography (PET/CT) is increasing. This resurgence of an old tracer has been fueled by several factors including superior diagnostic performance over standard 99mTc-based bone scintigraphy, growth in the availability of PET/CT imaging systems, increase in the number of regional commercial distribution centers for PET radiotracers, the recent concerns about potential chronic shortages with 99mTc based radiotracers, and the recent decision by the Centers for Medicare and Medicaid Services to reimburse for 18F-NaF PET/CT for evaluation of patients with known or suspected bone metastases through the National Oncologic PET Registry. The major goal of this article is to review the current evidence on the diagnostic utility of 18F-NaF in the imaging assessment of bone and joint in a variety of clinical conditions.

Prognostic Factors in Patients Treated with 223Ra: The Role of Skeletal Tumor Burden on Baseline 18F-Fluoride PET/CT in Predicting Overall Survival

“…In addition, 18 F-fluoride uptake is 2-fold higher than 99m Tc-MDP, leading to improved lesion detectability (29,30). Furthermore, although fluoride PET/CT has a higher cost, acquisition time is faster and spatial resolution higher, and images may be acquired earlier (31)(32)(33). All these factors lead to a better performance of fluoride PET/CT to detect bone lesions and to define equivocal bone metastases (18,34,35).…”

Histological and Nuclear Medical Comparison of Inflammation After Hemostasis with Non‐Thermal Plasma and Thermal Coagulation

“…Figure 4 shows the representative PET/CT images. Since the 18 F ion that is attributable to metabolism of 18 F-FDG in vivo accumulates in bone, [22] the vertebrae were clearly visualized inall mice (Figure4, circles). On day 5, prominent radioactivity accumulated in the laparotomy wound, and it was difficult to compare the radioactivity accumulated in the liver in the two groups.…”

Stres Fraktürüne Nükleer Tıp Yaklaşımı

“…PET/BT' nin BT komponenti ile hem aktivite tutulumu olan bölgenin tam anatomik lokalizasyonunu sağlanır hem de kemik dışı yapıların değerlendirilmesi sağlanır. Fischer ve arkadaşlarının yaptığı bir çalışmada F-18 NaF PET/BT' nin ayakta açıklanamayan kemik ağrıları olan hastaların yönetiminde etkili olduğu gösterilmiştir [31][32] . Sonuç olarak, kemik dokusunda patoloji olan bölgedeki metabolik değişiklikleri saptayan, fonksiyonel ve moleküler görüntüleme imkanı sağlayan nükleer tıp yöntemlerinin stres fraktürünün erken dönemde tanısını koymada önemi göz ardı edilmemelidir ve bu yöntemlerin öneminin bilinmesinin hastaların yönetiminde anlamlı katkılar sağladığını düşünmekteyiz.…”