Sodium Alginate Modified Platinum Nanozymes With Highly Efficient and Robust Oxidase-Like Activity for Antioxidant Capacity and Analysis of Proanthocyanidins

He, Shao‐Bin; Yang, Liu; Lin, Xiu-Ling; Peng, Hua-Ping; Lin, Zhen; Deng, Hao‐Hua; Chen, Wei; Hong, Guolin

doi:10.3389/fchem.2020.00654

Cited by 13 publications

(2 citation statements)

References 35 publications

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“…Wu et al used β-cyclodextrin polymers for the surface modification of CeO 2 NPs, and the modified CeO 2 NPs had enhanced water solubility, biocompatibility and antioxidant properties. CeO 2 NPs have multispecies enzymatic activity and their ability to scavenge free radicals is relatively insufficient. , Yang et al used a nanoscale poly(tannic acid) (PTA) coating to surface-modify CeO 2 NPs and constructed multifunctional composite CeO 2 NPs with multiple antioxidant properties. The surface-modified CeO 2 NPs by the PTA coating have stronger antioxidant activity and can better protect cells under the oxidative stress microenvironment.…”

Section: Functionalization Modification Of Nanozymesmentioning

confidence: 99%

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Liu

et al. 2023

ACS Appl. Nano Mater.

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Nanomaterials that can mimic the activity of various enzymes have been studied extensively in the biomedical field in recent years. Nanozymes offer better stability and economic value in comparison to natural enzymes. Additionally, nanozymes have characteristics of nanomaterials, such as photothermal properties and designability, and therefore have considerable potential. The cellular microenvironment provides the basis for maintaining normal cell growth and function. Increasing evidence shows that imbalances in the homeostasis of the cellular microenvironment constitute a major factor in the development of many diseases. Nanozymes have received considerable attention in recent years as regulators of the cellular microenvironment. In this Review, research on the use of nanozymes to remodel the disease microenvironment is discussed. First, the definition, classification, and enzyme-like activities of nanozymes are introduced; several major disease microenvironments are summarized including tumor, inflammatory, and trauma microenvironments. The role of nanozymes in disease microenvironments and the main strategies for constructing intelligent and responsive nanozyme systems are discussed. The specific applications of nanozymes in remodeling the diseased microenvironment are highlighted. Finally, the therapeutic strategies of nanozymes to remodel the disease microenvironment are summarized and prospected. Nanozyme disease microenvironment remodeling is expected to become a major therapeutic strategy or an adjunct for the prevention and treatment of related diseases.

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Section: Functionalization Modification Of Nanozymesmentioning

confidence: 99%

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Liu

et al. 2023

ACS Appl. Nano Mater.

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“…Platinum is one of the most ideal shells with which to protect Fe 3 O 4 nanoparticles from damage and aggregation [34]. Platinum (Pt) is a transition metal exhibiting chemical inertness and stability in air or a humid environment [35], and Pt NPs also have peroxidaselike activity [36][37][38]. This may be caused by the base-like decompositions of H 2 O 2 on the surfaces of Pt NPs [33].…”

Section: Introductionmentioning

confidence: 99%

Facile preparation of Fe ₃ O ₄ @Pt nanoparticles as peroxidase mimics for sensitive glucose detection by a paper-based colorimetric assay

Wang

Chen

et al. 2022

R. Soc. open sci.

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A simple strategy to rapidly detect glucose was developed by utilizing core (Fe 3 O 4 )–shell (Pt) magnetic nanoparticles (Fe 3 O 4 @Pt NPs) as a nanoenzyme and a paper-based colorimetric sensor. In the presence of H 2 O 2 , Fe 3 O 4 @Pt NPs catalyze the redox reaction of 3,3′,5,5′-tetramethylbenzidine (TMB) and generate a colour change from colourless to blue. On this basis, a colorimetric glucose sensing method assisted by glucose oxidase (GOx) was developed. Under the optimal conditions, the detection limits of the proposed assay for H 2 O 2 and glucose were 0.36 µM and 1.27 µM, respectively. Furthermore, the fabricated colorimetric method was successfully applied to analyze glucose concentrations by using a paper device as a measuring platform without a spectrometer. In addition, this method exhibited satisfactory recovery for glucose detection in human serum samples and urine samples, which satisfied the requirements for normal detection of real samples. This study provides a good candidate for health monitoring of glucose and also expands the applications of nanoenzymes and paper-based colorimetric assays in point-of-care testing.

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Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

et al. 2021

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Wireless nano‐/micromotors powered by chemical reactions and/or external fields generate motive forces, perform tasks, and significantly extend short‐range dynamic responses of passive biomedical microcarriers. However, before micromotors can be translated into clinical use, several major problems, including the biocompatibility of materials, the toxicity of chemical fuels, and deep tissue imaging methods, must be solved. Nanomaterials with enzyme‐like characteristics (e.g., catalase, oxidase, peroxidase, superoxide dismutase), that is, nanozymes, can significantly expand the scope of micromotors’ chemical fuels. A convergence of nanozymes, micromotors, and microfluidics can lead to a paradigm shift in the fabrication of multifunctional micromotors in reasonable quantities, encapsulation of desired subsystems, and engineering of FDA‐approved core–shell structures with tuneable biological, physical, chemical, and mechanical properties. Microfluidic methods are used to prepare stable bubbles/microbubbles and capsules integrating ultrasound, optoacoustic, fluorescent, and magnetic resonance imaging modalities. The aim here is to discuss an interdisciplinary approach of three independent emerging topics: micromotors, nanozymes, and microfluidics to creatively: 1) embrace new ideas, 2) think across boundaries, and 3) solve problems whose solutions are beyond the scope of a single discipline toward the development of micro‐bio‐chemo‐mechanical‐systems for diverse bioapplications.

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Sodium Alginate Modified Platinum Nanozymes With Highly Efficient and Robust Oxidase-Like Activity for Antioxidant Capacity and Analysis of Proanthocyanidins

Cited by 13 publications

References 35 publications

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Facile preparation of Fe ₃ O ₄ @Pt nanoparticles as peroxidase mimics for sensitive glucose detection by a paper-based colorimetric assay

Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

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Sodium Alginate Modified Platinum Nanozymes With Highly Efficient and Robust Oxidase-Like Activity for Antioxidant Capacity and Analysis of Proanthocyanidins

Cited by 13 publications

References 35 publications

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Facile preparation of Fe 3 O 4 @Pt nanoparticles as peroxidase mimics for sensitive glucose detection by a paper-based colorimetric assay

Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

Contact Info

Product

Resources

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Facile preparation of Fe ₃ O ₄ @Pt nanoparticles as peroxidase mimics for sensitive glucose detection by a paper-based colorimetric assay