Sodium arsenite impairs insulin secretion and transcription in pancreatic β-cells

Dı́az-Villaseñor, Andrea; Sánchez-Soto, M. Carmen; Cebrián, Mariano E.; Ostrosky‐Wegman, Patricia; Hiriart, Marcia

doi:10.1016/j.taap.2005.11.015

Cited by 97 publications

(57 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal studies show that arsenic disturbs glucose production in the liver and decreases insulin secretion and synthesis in pancreatic β cells. 17 In addition, arsenic exposure causes hyperglycemia, hyperinsulemia, and low-insulin sensitivity in rats, which is consistent with insulin resistance observed in type 2 diabetes. 18 Stemming the pandemic of type 2 diabetes is a public health priority and will require a multifaceted approach.…”

supporting

confidence: 65%

Environmental Arsenic Exposure and Diabetes

2013

Encyclopedia of Metalloproteins

View full text Add to dashboard Cite

show abstract

supporting

confidence: 65%

Environmental Arsenic Exposure and Diabetes

2013

Encyclopedia of Metalloproteins

View full text Add to dashboard Cite

show abstract

“…The latter was deduced from altered expression of the following genes: (1) Pdx1 (previously known as Iuf1) [93][94][95], a transcription factor that is essential for pancreas development, insulin production and glucose homeostasis [96]; and (2) the insulin gene [97]. Other studies reported effects on glucose uptake, induction of ROS production, interference with the activity of key antioxidant enzymes [98], apoptosis, necrosis and inflammation reactions [39,93] (Fig.…”

Section: Metalsmentioning

confidence: 99%

Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function

et al. 2011

View full text Add to dashboard Cite

The prevalence of diabetes mellitus is currently at epidemic proportions and it is estimated that it will increase even further over the next decades. Although genetic predisposition and lifestyle choices are commonly accepted reasons for the occurrence of type 2 diabetes, it has recently been suggested that environmental pollutants are additional risk factors for diabetes development and this review aims to give an overview of the current evidence for this. More specifically, because of the crucial role of pancreatic beta cells in the development and progression of type 2 diabetes, the present work summarises the known effects of several compounds on beta cell function with reference to mechanistic studies that have elucidated how these compounds interfere with the insulin secreting capacity of beta cells. Oestrogenic compounds, organophosphorus compounds, persistent organic pollutants and heavy metals are discussed, and a critical reflection on the relevance of the concentrations used in mechanistic studies relative to the levels found in the human population is given. It is clear that some environmental pollutants affect pancreatic beta cell function, as both epidemiological and experimental research is accumulating. This supports the need to develop a solid and structured platform to fully explore the diabetes-inducing potential of pollutants.

show abstract

“…48 On the other hand, many studies have indicated that arsenic could alter signaling transduction factors, including NFκB, p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor-α (TNFα), phosphatidydylinositol-3-kinase (PI3K) and PI3K-dependent phosphorylation of protein kinase B (PKB/ Akt), and affecting the insulin-stimulated glucose uptake (ISGU) in adipocytes or skeletal muscle cells, which may potentially link with insulin resistance. [49][50][51][52] PI3K signaling is a pivotal role in the metabolic actions of insulin and its activation regulates multiple signaling transductions.…”

Section: Arsenicmentioning

confidence: 99%