Sodium benzoate induced developmental defects, oxidative stress and anxiety-like behaviour in zebrafish larva

Gaur, Himanshu; Purushothaman, Srinithi; Pullaguri, Narasimha; Bhargava, Yogesh; Bhargava, Anamika

doi:10.1016/j.bbrc.2018.05.171

Cited by 40 publications

(27 citation statements)

References 29 publications

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“…In PC-12 cell line, Almal induced cell death dose dependently, which is consistent with similar findings reported by a previous study [33]. At the concentrations of 0.015, 0.25, or 0.5 mg/ml, sodium benzoate had no deleterious effects on cell growth and the survival rate of PC-12 cells compared to the controls [7].…”

Section: Discussionsupporting

confidence: 91%

“…In a study of sodium benzoate on HeLa cells and rat neurons, there were indications of apoptosis and disruption of calcium balance and mitochondrial membrane potentials [29]. In addition, previous studies have indicated that the oral administration of sodium benzoate induced anxiety, motor and memory impairments, increased brain oxidative stress and renal injury in vivo [30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Sodium Benzoate on Apoptosis and Mitochondrial Membrane Potential After Aluminum Toxicity in PC-12 Cell Line

Rashedinia

Saberzadeh

Khodaei

et al. 2020

IJT

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Background: Sodium benzoate, a food preservative, prevents the growth of fungi and bacteria. Numerous studies have reported the protective effects of sodium benzoate on the nervous system. This study investigated the effect of sodium benzoate on cell apoptosis and mitochondrial function in an aluminum cell toxicity model. Methods: After 48 hr of treating PC-12 cells with varying concentrations of sodium benzoate (0.125, 0.25 or 0.5 mg/ml) in the presence of aluminum maltolate (500 μM), the cell viability was assessed by MTT assay. The type of cell death (necrosis or apoptosis) was analyzed by flow cytometry (7-ADD/An V-PE staining). Also, rhodamine 123 was used to measure the Mitochondrial Membrane Potential (MMP). The acetylcholinesterase activity (AChE) was assessed by Ellman’s method. Results: It was observed that sodium benzoate inhibited aluminum induced cell death within 48hr. Sodium benzoate at a concentration of 0.5 mg/ml significantly reduced the apoptotic cells that had been exposed to aluminum. Exposure of PC-12 cells with sodium benzoate and aluminum, increased the AChE activity, although, no significant changes in mitochondrial membrane potential were observed. Conclusion: Sodium benzoate may provide its protective effects through increased AChE activity and inhibiting apoptosis induced by aluminum toxicity. It is likely that the disruption of MMP is neither involved in the induction of apoptosis by aluminum nor in the protective effect of sodium benzoate.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Effect of Sodium Benzoate on Apoptosis and Mitochondrial Membrane Potential After Aluminum Toxicity in PC-12 Cell Line

Rashedinia

Saberzadeh

Khodaei

et al. 2020

IJT

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“…Comparison to the batch system for fully activated sludge, for MLSS of 4.8 g/L the cumulative biogas production dropped significantly from 395 mL to 59.6 mL, 43.4 mL and 22 mL. The SB solution interfere the production biogas through the elimination of the microorganisms or reduce the activity the microorganisms to degrade organic substances [21,22]. Increasing the OLR will affect to the reduction of formation of biogas because higher OLR required significant amount of microorganisms to overcome.…”

Section: Organic Loading Rate (Olr)mentioning

confidence: 93%

“…In AD process, increasing OLR of organic substances will significantly produce amount of biogas, the bacteria to produce methane depends on the availability of organic acids and also bacteria of acid and acetate to produce hydrogen [20]. The function of SB as a preservative substance is to prevent the growth of microorganisms [21]. Increasing the SB will increase the substance to inhibit the growth of microorganisms.…”

Section: Organic Loading Rate (Olr)mentioning

confidence: 99%

Kinetic of Biogas Production in a Batch Anaerobic Digestion Process with Interference of Preservative Material of Sodium Benzoate

Sumantri

Hadiyanto

2020

Bull. Chem. React. Eng. Catal.

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Sodium benzoate is a preservative compounds which are widely used for both food and beverage products. The treatment of waste water containing this compound was normally conducted in a anaerobic digestion (AD) using a batch reactor system at a room temperature. The anaerobic process eventually produced biogas which can be used for bioenergy. This research was aimed to evaluate the production of biogas from by synthetic solution models containing sodium benzoate (SB). The experiment was performed in a variation of Mixed Liquor Suspended Solid (MLSS) of 4.8 and 7.2 g/L, and initial sodium benzoate concentration of 400, 600, and 800 mg/L. The digestion was performed at 60 days, while the biogas content was measured every 2 days. The results indicated a reduction in the cumulative biogas by the addition of sodium benzoate, compared to the control condition. Moreover, the decrease in organic loading rate (OLR) of SB in wastewater follows the first order kinetic with kinetic rate constant (k) was 0.0432 to 0.1254 (day−1) for MLSS of 4.8 g/L and 0.0276 to 0.0372 (day−1) for 7.2 g/L MLSS. Copyright © 2020 BCREC Group. All rights reserved

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“…Food spoilage and the growth of pathogenic bacteria can be suppressed by adding bacteriostatic agents to foods; however, these preservatives can present health hazards of their own. For example, the common preservative sodium benzoate has been seen to produce oxidative stress and anxiety‐like behavior in zebrafish larva (Gaur et al, ) and to react with ascorbic acid in beverages to produce the carcinogen benzene (Piper & Piper, ). Potassium sorbate at large dosages can cause headaches and chest pain, and after long‐term use may even cause DNA damage (Mamur, Yuzbasioglu, Unal, & Yılmaz, ; Negi, ; Chaleshtori, Arian, & Chaleshtori, ).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of a hexahydro‐β‐acids/methyl‐β‐cyclodextrin inclusion complex against bacteria related to foodborne illness

Zhao

Liu

2019

Journal of Food Safety

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In this study, we investigated the antibacterial activity of hexahydro‐β‐acids/methyl‐β‐cyclodextrin inclusion complex (HBA/M‐β‐CD) and researched its antibacterial mechanism against Staphylococcus aureus and Enterobacter sakazakii. The result showed that bacteria had different sensitivities to HBA/M‐β‐CD with diameters of inhibition zones ranging from 7.8 ± 0.5 to 14.8 ± 0.7 mm and minimum inhibitory concentration (MIC) values from 16.25 to 65.00 μg/mL. Among these bacteria, S. aureus (G(+)) and E. sakazakii (G(−)) were most sensitive to HBA/M‐β‐CD, and MIC value is 16.25 and 32.50 μg/mL, respectively. Also, HBA/M‐β‐CD had potential inhibition effect on the bacterial growth of S. aureus and E. sakazakii. Moreover, the treatment with HBA/M‐β‐CD led to a release of cell contents into the culture medium, indicating damage to the plasma membrane. Scanning electron microscopy revealed permeabilization of S. aureus membranes, and shrinkage and roughening of E. sakazakii cells. HBA/M‐β‐CD also reduced the activity of succinate dehydrogenase (SDH) in bacterial cultures, indicating that HBA/M‐β‐CD interfere key enzyme metabolism. Practical Applications In the actual food system of western‐style ham sausage, HBA/M‐β‐CD revealed a great antibacterial effect to control the total bacteria count, and could stabilize the pH value. The result provided the theoretical and practical basis for the application of HBA/M‐β‐CD in foods.

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Sodium benzoate induced developmental defects, oxidative stress and anxiety-like behaviour in zebrafish larva

Cited by 40 publications

References 29 publications

Effect of Sodium Benzoate on Apoptosis and Mitochondrial Membrane Potential After Aluminum Toxicity in PC-12 Cell Line

Effect of Sodium Benzoate on Apoptosis and Mitochondrial Membrane Potential After Aluminum Toxicity in PC-12 Cell Line

Kinetic of Biogas Production in a Batch Anaerobic Digestion Process with Interference of Preservative Material of Sodium Benzoate

Antibacterial activity of a hexahydro‐β‐acids/methyl‐β‐cyclodextrin inclusion complex against bacteria related to foodborne illness

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