Sodium butyrate ameliorates S100/FCA-induced autoimmune hepatitis through regulation of intestinal tight junction and toll-like receptor 4 signaling pathway

Wu, Jer Horng; Zou, Jiayun; Hu, En-De; Chen, Da-Zhi; Chen, Lu; Lu, Feng‐Bin; Xu, Lei; Zheng, Ming‐Hua; Li, Hui; Huang, Yu; Jin, Xiao-ya; Gong, Yuewen; Lin, Zhuo; Wang, Xiaodong; Zhao, Mingfang; Chen, Yongping

doi:10.1016/j.imlet.2017.08.005

Cited by 31 publications

(28 citation statements)

References 46 publications

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“…Butyrate is an important energy source for gut enterocytes (Chen et al, 2018), and it is mainly from butyric acid-producing bacteria in gut (Hamer et al, 2008). Lack of butyric acid can result in gut permeability increase (Wu et al, 2017). In this experiment, the gut permeability was significantly increased, and butyrate content was sharply decreased due to the reduction in the relative abundance of butyric acid producing bacteria.…”

Section: Discussionmentioning

confidence: 73%

Effects of High Carbohydrate Diet-Modulated Microbiota on Gut Health in Chinese Perch

Zhang

Liang

et al. 2020

Front. Microbiol.

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High carbohydrate diet-induced damage in gut is linked to changes in gut permeability and microbiota. However, the mechanisms of action are not clear, especially in nonmammals. We performed the gut microbiota profiling in Chinese perch fed with different content of starch diets (0, 10, and 20%) by 16S rRNA sequencing. The gut permeability, metabolites, histological analysis, and inflammatory infiltration were evaluated. We found that gut microbial diversity, beneficial bacteria quantity, and lactic acid content were higher in C10 group than in the other groups. The lower level of gut microbial diversity was observed in C20 group, and mycoplasma was the overwhelmingly dominant species, but the butyric acid-producing bacteria and butyric acid level were significantly reduced. The gut permeability in C20 group was also increased due to the decreased mRNA expression levels of tight junction proteins caused by the butyric acid deficiency and gut lipid droplets accumulation. Then a large amount of LPS penetrated into the plasma, resulting in inflammation. These results suggested that high carbohydrate dietinduced damage in gut could be attributed to the endotoxemia, permeability, and gut microbiota, especially the role of mycoplasma and butyric acid-producing bacteria. In addition, predictive functional profiling of microbial communities by PICRUSt showed that C10 group enriched pathway related to membrane transport and down-regulated the pathways related to energy, coenzyme factor and vitamin metabolism, while C20 group exhibited reversed results. These data showed that the high-carbohydrate diet reversed the beneficial changes in gut microbial metabolism resulted from the mediumcarbohydrate diet, and further demonstrated that microbiota played a key role in the gut damage caused by the high-carbohydrate diet. Our findings provide a reference for the targeted regulation of gut microbiota to mitigate the damage caused by the increase in starch content in fish feed (cost saving).

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Section: Discussionmentioning

confidence: 73%

Effects of High Carbohydrate Diet-Modulated Microbiota on Gut Health in Chinese Perch

Zhang

Liang

et al. 2020

Front. Microbiol.

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“…The maintenance of the intestinal epithelial barrier is critical to reducing systemic inflammation as evidenced by the emerging association between obesity and increased intestinal permeability [7,107]. Recent studies have suggested that SCFAs enhance the expression of epithelial barrier-forming molecules and mucin production, which are partly mediated by 5′ adenosine monophosphate-activated protein kinase (AMPK) activation, HDACi activity and TLR4 pathway [108,109,110,111]. It is known that SCFAs activate several cell surface G-protein-coupled receptors (GPCRs), such as GPR43, GPR41, GPR109A, and Olfr78 [112,113,114].…”

Section: The Role Of Secondary Bas and Scfas In Colonic Inflammationmentioning

confidence: 99%

Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer

Zeng

Umar

Rust

et al. 2019

IJMS

338

201

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Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial metabolites in the colon, cause opposing effects on colonic inflammation at chronically high physiological levels. Primary BAs play critical roles in cholesterol metabolism, lipid digestion, and host–microbe interaction. Although BAs are reabsorbed via enterohepatic circulation, primary BAs serve as substrates for bacterial biotransformation to secondary BAs in the colon. High-fat diets increase secondary BAs, such as deoxycholic acid (DCA) and lithocholic acid (LCA), which are risk factors for colonic inflammation and cancer. In contrast, increased dietary fiber intake is associated with anti-inflammatory and anticancer effects. These effects may be due to the increased production of the SCFAs acetate, propionate, and butyrate during dietary fiber fermentation in the colon. Elucidation of the molecular events by which secondary BAs and SCFAs regulate colonic cell proliferation and inflammation will lead to a better understanding of the anticancer potential of dietary fiber in the context of high-fat diet-related colon cancer. This article reviews the current knowledge concerning the effects of secondary BAs and SCFAs on the proliferation of colon epithelial cells, inflammation, cancer, and the associated microbiome.

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“…Obese, diabetic models in a simplistic context exhibit fatty, insulin resistant livers due to increased triglyceride content and decreased β oxidation within the tissue, which is also associated a pro-inflammatory state. Supplementation of butyrate or butyrogenic bacterial strains is associated with the reduction of ectopic lipids in hepatic tissue [ 172 , 173 , 174 , 175 ]. For example, Jin et al assessed the effect of oral sodium butyrate supplementation (0.6 g/kg body weight/day) in female C57BL/6J mice fed either a liquid control (12% energy from fat) or Westernized diet (25% energy from fat, 50% w/w sucrose supplementation) for 6 weeks [ 172 ].…”

Section: Butyrate and Peripheral Tissuesmentioning

confidence: 99%

“…Additionally butyrate-supplemented rats exhibited significantly increased hepatic peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α), a transcriptional coactivator important in increasing mitochondrial biogenesis and function, expression [ 173 ]. In a murine model of autoimmune hepatitis induced by Freund’s complete adjuvant, male C57BL/6 mice receiving 300 mg/kg sodium butyrate as a daily gavage for 3 weeks exhibited reduced mRNA and protein content of NF-κB, IL-6 and TNF-α relative to the hepatitis controls [ 174 ]. Finally, Liu and colleagues administered C. butyricum (5 × 10 8 CFU) intragastrically in male ICR mice for 5 days prior to acute liver injury induced via carbon tetrachloride (CCl 4 ) intraperitoneal injection [ 175 ].…”

Section: Butyrate and Peripheral Tissuesmentioning

confidence: 99%

Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance

2017

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Increased dietary fiber consumption has been associated with many beneficial effects, including amelioration of obesity and insulin resistance. These effects may be due to the increased production of short chain fatty acids, including propionate, acetate and butyrate, during fermentation of the dietary fiber in the colon. Indeed, oral and dietary supplementation of butyrate alone has been shown to prevent high fat-diet induced obesity and insulin resistance. This review focuses on sources of short chain fatty acids, with emphasis on sources of butyrate, mechanisms of fiber and butyrate metabolism in the gut and its protective effects on colon cancer and the peripheral effects of butyrate supplementation in peripheral tissues in the prevention and reversal of obesity and insulin resistance.

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Sodium butyrate ameliorates S100/FCA-induced autoimmune hepatitis through regulation of intestinal tight junction and toll-like receptor 4 signaling pathway

Cited by 31 publications

References 46 publications

Effects of High Carbohydrate Diet-Modulated Microbiota on Gut Health in Chinese Perch

Effects of High Carbohydrate Diet-Modulated Microbiota on Gut Health in Chinese Perch

Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer

Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance

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