Sodium butyrate improves antioxidant stability in sub-acute ruminal acidosis in dairy goats

Abstract

BackgroundCurrently, little is known about the effect of sodium butyrate (NaB) on oxidative stress following grain-induced sub-acute ruminal acidosis in dairy goats. In the present study, 18 lactating dairy goats implanted with a ruminal cannula and permanent indwelling catheters in the portal and hepatic veins were randomly allocated into 3 treatment groups over 20 weeks: low grain (LG, 40% grain; n = 6), high grain (HG, 60% grain; n = 6) and high grain with sodium butyrate (HG + NaB, 60% grain + NaB; n = 6).ResultsWhen added to the HG diet, NaB increased the mean ruminal pH and reduced the levels of ruminal, portal and hepatic LPS; Additionally, we observed an increase in SOD1, SOD2, SOD3, GPX1 and CAT mRNA expression, increased levels of TSOD and CAT enzyme activity as well as increased total antioxidant capacity (T-AOC) and decreased malondialdehyde (MDA) in both the liver and plasma, while GPx activity increased in the liver of goats fed the HG + NaB diet. The mRNA expression of UGT1A1, NQO1, MGST3, and Nrf2, as well as total Nrf2 protein levels were increased in goats fed the HG + NaB diet.ConclusionsOur study indicates that sodium butyrate could improve the oxidative status in sub-acute ruminal acidosis through the partial activation of Nrf2-dependent genes.

Tributyrin‐supplemented high‐soya bean meal diets of juvenile black sea bream, Acanthopagrus schlegelii : Study on growth performance and intestinal morphology and structure

“…Our results revealed that high‐SBM levels in the diet might cause oxidative damage in juvenile black sea bream but this damage can be alleviated by TB supplementation, which improves the antioxidant capacity in the serum. A study of the relation between dietary sodium butyrate and antioxidant capacity performed by Ma, Abaker, Bilal, Dai, and Shen () demonstrated that the mechanism by which sodium butyrate supplementation alleviates oxidative damage is partially related to the Nrf2 signalling pathway and suggested that the mRNA levels of the Nrf2 signalling pathway genes upregulated antioxidant enzyme activities.…”

Sodium butyrate protects against high-fat diet-induced oxidative stress in rat liver by promoting expression of nuclear factor E2-related factor 2

“…Oxidative stress induces insulin resistance by impairing insulin signal transduction (36) . Previous studies have shown that administering NaB attenuates oxidative stress in many tissues (37,38) and cells (39) . PI3K and p-AKT play key roles in insulin signalling pathway.…”

“…PI3K and p-AKT play key roles in insulin signalling pathway. NaB increases PI3K and p-AKT protein levels (39) and alleviates the oxidative status in sub-acute ruminal acidosis through partial activation of antioxidant enzyme genes (37) . In agreement with these previous findings, we found that NaB restored the hepatic expression of IRS1, PI3K and p-AKT that was down-regulated by high-fat diet.…”

Reproductive tract development and histomorphometric analysis of testes in neonatal Zaraibi kids raised on milk replacer supplemented with sodium butyrate

“…This study demonstrated that the supplementation of SB in MR promotes antioxidant activity and alleviates oxidative stress during the suckling period. The higher levels of serum SOD, CAT and GPX in goat kids of G2 than those of kids of G1 may be related to increasing of ruminal pH and decreasing of lipopolysaccharide levels (Ma, Abaker, Bilal, Dai, & Shen, 2018), and these agents may reduce the inflammatory response and the production of reactive oxygen species (ROS). Besides, other potential mechanisms by which butyrate may enhance enzyme activity and antioxidant activity.…”