Sodium Butyrate Inhibits Colorectal Cancer Cell Migration by Downregulating Bmi‐1 Through Enhanced miR‐200c Expression

Abstract

NaB inhibits CRC cell migration by enhancing miR-200c expression-mediated downregulation of Bmi-1. These findings support the utility of NaB in colorectal cancer therapy.

Sodium butyrate inhibits migration and induces AMPK‐mTOR pathway‐dependent autophagy and ROS‐mediated apoptosis via the miR‐139‐5p/Bmi‐1 axis in human bladder cancer cells

“…The key roles of Bmi‐1 in cell migration, autophagy, ATP production, and ROS generation have been reported in several studies . Thus, we expected that NaB would modulate migration, autophagy, ATP production, and ROS generation through the miR‐139‐5p/Bmi‐1 axis in human bladder cancer cells.…”

“…Accumulating evidence has proven that Bmi-1 is a key target in the clinical treatment of various malignancies due to its modulated roles in AMPK-dependent autophagy and cell migration. 18,[20][21][22] The miR-200 family is closely related to the EMT, and upregulating the miR-200 family leads to a reversal of the EMT by regulating Bmi-1. 20,46,58 Moreover, another original study demonstrated that cells derived from Bmi1 -/mice have impaired mitochondrial function, which led to a marked increase in the intracellular levels of ROS.…”

“…The key roles of Bmi-1 in cell migration, autophagy, ATP production, and ROS generation have been reported in several studies. 17,18,20,46,47 Thus, we expected that NaB would modulate migration, autophagy, ATP production, and ROS generation through the miR-139-5p/Bmi-1 axis in human bladder cancer cells. To verify the exact molecular link between miR-139-5p-mediated depletion of Bmi-1 and the antitumor effects of NaB treatment, we evaluated the effects of miR-139-5p knockdown in NaB-treated cells.…”

“…The epithelial‐mesenchymal transition (EMT) is a vital process in cancer metastasis and is attracting increasing attention in basic research on cancer therapies . Interestingly, Bmi‐1 has been reported to be an important target of microRNAs that is closely relate to the reversal of EMT processes . In addition, depletion of Bmi‐1 pharmacologically and genetically induces cell death and triggers autophagy in other tumors …”

“…19 Interestingly, Bmi-1 has been reported to be an important target of microRNAs that is closely relate to the reversal of EMT processes. 20 In addition, depletion of Bmi-1 pharmacologically and genetically induces cell death and triggers autophagy in other tumors. 21,22 Reactive oxygen species are essential cellular components and participate in multiple biological processes.…”