Sodium butyrate modulates a methamphetamine‐induced conditioned place preference

Abstract

Previous studies demonstrated that histone acetylation modulated the transcription of associated gene expression and thus contributed to the persistence of addictive behaviors and neuroplasticity. Nonetheless, the roles of histone acetylation in distinct phases of methamphetamine (METH)-induced conditioned place preference (CPP) remain unclear. The current study examines the effects of the histone deacetylases (HDACs) inhibitor sodium butyrate (NaB) on the acquisition, extinction, and reinstatement of METH-induced CPP in mice. Our results showed that 1 mg/kg METH induced CPP in mice after four conditioning sessions. METH-induced CPP was extinguished after three extinction training sessions and could be triggered by the same dose (1 mg/kg) of METH on the reinstatement test day. Meanwhile, NaB (400 mg/kg) per se had no effect on the natural preference of mice, but injections of NaB during the conditioning and extinction phases facilitated the acquisition and extinction of METH-induced CPP, respectively. Additionally, although the effect of a single NaB injection prior to the trigger of CPP reinstatement was not observed, repeated NaB injections during the extinction phase totally blocked the reinstatement of METH-induced CPP. Taken together, our results suggested a specific effect of histone acetylation on modulating distinct phases of METH-induced CPP and that treatment of NaB during the extinction phase not only produced beneficial effects on eliminating already established CPP but also blocked the reinstatement of METH-induced CPP. © 2016 Wiley Periodicals, Inc.

Differential perturbations of gut microbial profiles and co‐occurrence networks among phases of methamphetamine‐induced conditioned place preference

“…Propionate treatment reduced reward response to high‐energy foods in human (Byrne et al., 2016). Repeated sodium butyrate treatments at the EXT phase could inhibit the reinstatement of METH‐induced CPP in mice (Zhu et al., 2017). In addition, we found Prevotella was negatively correlated with SCFA metabolism at the ACQ phase.…”

Characterization of the Brain Functional Architecture of Psychostimulant Withdrawal Using Single-Cell Whole-Brain Imaging

“…The doses were 4 mg/kg/d for methamphetamine, 24 mg/kg/d for nicotine, and 60 mg/kg/d for cocaine. These doses were chosen based on previous studies that indicated rewarding effects during use, resulting in withdrawal-like symptoms after the cessation of chronic use ( Johnson et al, 2008 ; Fish et al, 2010 ; Eisener-Dorman et al, 2011 ; Stoker and Markou, 2011 ; Stoker et al, 2012 ; Tracy et al, 2016 ; Zhu et al, 2017 ). Each drug was dissolved in saline, and the pH was adjusted to 7.4.…”

“…This method of acute withdrawal was chosen to control the amount of drug each animal received and create strong dependence in a short period of time. The psychostimulant doses were chosen based on previous studies that reported rewarding effects during use and observed withdrawal-like symptoms after the cessation of chronic exposure for each drug ( Johnson et al, 2008 ; Fish et al, 2010 ; Eisener-Dorman et al, 2011 ; Stoker and Markou, 2011 ; Stoker et al, 2012 ; Tracy et al, 2016 ; Zhu et al, 2017 ). We then used single-cell whole-brain activity to identify coactivation patterns of brain regions in the network that was associated with each treatment using hierarchical clustering.…”

The Developmental Neuroepigenetics of Substance Abuse

“…Coadministration of VA and amphetamine upregulated CREB phosphorylation and Fos activation and attenuated locomotor activity, indicating a cascade of intracellular effects that may change the activation patterns of the neurons involved [256]. Microinjection of BA into other areas of the brain, including the amygdala and striatum, also attenuated the drug-induced locomotor activity associated with psychostimulant use [257].…”