Sodium caseinate induces secretion of macrophage colony-stimulating factor from neutrophils

Santiago‐Osorio, Edelmiro; Mora, Lucy; Bautista, M.; Montesinos, Juan José; Martı́nez, Ignacio; Ramos‐Mandujano, Gerardo; Zambrano, Reina; García, Alberto Monroy; Weiss‐Steider, Benny; Ledesma‐Martínez, Edgar; Aguiñiga, Itzen

doi:10.1016/j.imbio.2009.03.003

Cited by 6 publications

(8 citation statements)

References 25 publications

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“…It is well known that cytokines such as G-CSF and GM-CSF are inducers of granulopoiesis [18,19,27,28] and both of these cytokines are induced by CasNa and casein [2,9]. We found that CasNa increased the levels of both cytokines in serum and of G-CSF in bone marrow plasma (Table 2).…”

Section: Discussionsupporting

confidence: 54%

“…It has been shown that sodium caseinate, a salt of casein which is the main milk protein, inhibits in-vitro proliferation of normal and leukemic myeloid cell lines [22,23] and accelerates the transition of band cells from bone marrow to polymorphonuclear cells, thus including the induction of M-CSF [9]. CasNa is widely used in studies of in-vivo inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, our research group has recently shown that, after in-vitro stimulation with CasNa, granulocytes isolated from the bone marrow increased the production of M-CSF [9].…”

Section: Introductionmentioning

confidence: 96%

“…Taking into consideration the fact that band stage cells from bone marrow are differentiated into polymorphonuclear cells with CasNa [9], and myeloblasts and promyelocytic cells in mice bone marrow increase after intraperitoneal (i.p.) injection with CasNa [11], in this work we evaluated the possible induction of granulopoiesis in mice treated with CasNa.…”

Section: Introductionmentioning

confidence: 99%

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Sodium caseinate induces mouse granulopoiesis

et al. 2012

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

“…Moreover, our research group has recently shown that, after in-vitro stimulation with CasNa, granulocytes isolated from the bone marrow increased the production of M-CSF [9].…”

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Sodium caseinate induces mouse granulopoiesis

et al. 2012

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“…En un estudio se reportó que el caseinato de sodio indujo la producción del factor estimulante de colonias de macrófagos (Macrophage ColonyStimulating Factor, M-CSF) in vitro (3). Se ha demostrado, también, que la administración por vía intraperitoneal de caseinato de sodio en un modelo de ratón leucémico, incrementa su porcentaje de supervivencia (4), y que, tras la inyección del caseinato, este es capaz de movilizar células madre hematopoyéticas a la sangre periférica en el ratón (5).…”

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El caseinato de sodio incrementa número de linfocitos B en ratones

et al. 2017

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Introducción. El caseinato de sodio, una sal de la caseína utilizada como agente proinflamatorio en ratones, es capaz de inducir granulopoyesis en vivo e incrementar la producción de citocinas esenciales en dicho evento.Objetivo. Evaluar si el caseinato de sodio es capaz de inducir un efecto biológico en células de origen linfoide y la producción de citocinas involucradas con este linaje.Materiales y métodos: Se utilizaron ratones hembra BALB/c de 8 a 12 semanas de edad. Los animales se inyectaron cuatro veces, con intervalos de 48 horas, por vía intraperitoneal con 1 ml de caseinato de sodio (10 % de SFB p/v). La población de linfocitos B y la incorporación de bromodesoxiuridina (BrdU) se analizaron mediante citometría de flujo. La detección de la interleucina 7 se evaluó mediante la técnica de ELISA.Resultados. Tras la inyección por vía intraperitoneal, el número de linfocitos B 220+ provenientes del bazo de ratones tratados con caseinato de sodio aumentó comparados con los que solo recibieron el vehículo como tratamiento (89,01±1,03 Vs. 75,66±2,08), así como la incorporación de BrdU en células B220+ (38,59±4,48 Vs. 11,82±1,04). Se evidenció, asimismo, el incremento en la concentración de la interleucina 7 (IL-7) en el suero de los ratones tratados con caseinato de sodio, comparados con los que solo recibieron el vehículo (62,1±17,5 Vs. 26,9±4,4 pg/ml).Conclusión. El caseinato de sodio fue capaz de aumentar el número de linfocitos B en bazo de ratones, así como inducir la producción de IL-7, citocina clave para la linfopoyesis B.

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Nonredundant roles of keratinocyte‐derived IL‐34 and neutrophil‐derived CSF1 in Langerhans cell renewal in the steady state and during inflammation

et al. 2015

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IL-34 and colony stimulating factor 1 (CSF1) are two alternative ligands for the CSF1 receptor that play non-redundant roles in the development, survival and function of tissue macrophages and Langerhans cells (LCs). In this study, we investigated the spatio-temporal production of IL-34 and its impact on skin LCs in the developing embryo and adult mice in the steady state and during inflammation using Il34LacZ reporter mice and newly generated inducible Il34-knockout mice. We found that IL-34 is produced in the developing skin epidermis of the embryo, where it promotes the final differentiation of LC precursors. In adult life, LCs required IL-34 to continually self-renew in the steady-state. However, during UV-induced skin damage, LCs regeneration depended on neutrophils infiltrating the skin, which produced large amounts of CSF1. We conclude that LCs require IL-34 when residing in fully differentiated and anatomically intact skin epidermis, but rely on neutrophil-derived CSF1 during inflammation. Our demonstration that neutrophils are an important source of CSF1 during skin inflammation may exemplify the mechanism through which neutrophils promote their subsequent replacement with mononuclear phagocytes.

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Sodium caseinate induces secretion of macrophage colony-stimulating factor from neutrophils

Cited by 6 publications

References 25 publications

Sodium caseinate induces mouse granulopoiesis

Sodium caseinate induces mouse granulopoiesis

El caseinato de sodio incrementa número de linfocitos B en ratones

Nonredundant roles of keratinocyte‐derived IL‐34 and neutrophil‐derived CSF1 in Langerhans cell renewal in the steady state and during inflammation

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