Sodium deficit causing decreased weight gain and metabolic acidosis in infants with ileostomy

Bower, Timothy R.; Pringle, Kevin C.; Soper, Robert T.

doi:10.1016/s0022-3468(88)80370-1

Cited by 92 publications

(74 citation statements)

References 11 publications

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“…A urine sodium concentration of b 10 mmol/L has been quoted as an indicator of sodium depletion in CF infants in a UK consensus report [2] and is supported by a small study of sodium requirements for growth in 11 non-CF infants with ileostomies [10]. However urine sodium concentration is highly dependent on urine flow rate and its use as an indicator may be misleading.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of salt supplementation in CF infants

Coates

Crofton

Marshall

2009

Journal of Cystic Fibrosis

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Section: Introductionmentioning

confidence: 99%

Evaluation of salt supplementation in CF infants

Coates

Crofton

Marshall

2009

Journal of Cystic Fibrosis

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“…This may be due to immaturity [1], inappropriate urinary [2] or gastrointestinal salt toss [3], or iatrogenic causes, such as inappropriately limited salt intake or the chronic administration of potent diuretics [4]. In any case, if they are children, they often demonstrate diminished growth rates for both weight and length.…”

Section: Introductionmentioning

confidence: 99%

The effect of sodium repletion on growth and protein turnover in sodium-depleted rats

Wassner

1991

Pediatr Nephrol

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This study examines the consequences of sodium chloride supplementation to young rats previously made salt deficient by feeding them a sodium-deficient, chloride-replete diet. Salt-deficient rats received the test diet and distilled water for 10 days. As in our previous studies, rats cared for in this manner grew more slowly than rats fed the identical diet but allowed to drink 37 mM sodium chloride. On day 11, half of the salt-depleted animals received 37 mM sodium chloride in their drinking water. Sodium-deficient and supplemented rats were studied 1,2,5-6 and 11-12 days later. Urinary sodium rapidly rose from undetectable of 46 mEq/l urine within 1 day of supplementation and there was no further increase the next day, suggesting that extracellular fluid volumes were rapidly repleted. Food intake increased in the supplemented rats compared with the deficient animals but the difference in food intake equalled only 2.25 g/day for the first 2 days of supplementation. Over the last 12 days of the study, the slopes of both weight and length gains were equal in both the supplemented and the control group and significantly higher than those in the deficient rats. Over the course of the study, full catchup was not obtained in either length or weight. In addition to total weight and length gains, liver and kidney weights increased proportionately and by 5-6 days of supplementation were equivalent to the weights seen in the control group.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…For example, the patient in our case has taken salty or sour foods by choice. The previous report described that urinary sodium deficit would be a cause of decreased weight gain in infants with ileostomy [13]. However, examination of sodium concentration in urine and blood was performed when the patient was 2 years old, and the result showed less than 5 mEq/L in urine and normal serum in blood, respectively.…”

Section: Discussionmentioning

confidence: 96%