Sodium Di‐<i>N</i>‐Propylacetate (DPA) in the Treatment of Epilepsy:A Review

Simon, Daniel T.; Penry, J. Kiffin

doi:10.1111/j.1528-1157.1975.tb04738.x

Cited by 249 publications

(72 citation statements)

References 19 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Valproic acid (dipropylacetic acid, VPA) is a potent antiepileptic agent, being particularly effective in the treatment of petit mal epilepsy (Simon & Penry, 1975). Since fatty acids are in general extensively bound to plasma proteins in man (Goodman, 1958) it is assumed that VPA as a fatty acid would also be present in plasma in a highly bound form.…”

Section: Introduction Methodsmentioning

confidence: 99%

“…Since the degree of binding of VPA is roughly identical to phenytoin (Lunde, Rane, Yaffe, Lund & Sjoqvist, 1970) it is of interest to compare the binding of either antiepileptic Table 2 Statistical analyses of the correlation between several biochemical parameters and percent unbound VPA in twenty-four patients with renal disease. Plasma concentrations of VPA between 50 and 120 ig/ml are considered therapeutic (Simon & Penry, 1975;Schobben, van der Kleijn & Gabreels, 1975;Windorfer, Vogel & Sauer, 1976). In the upper range of these concentrations the protein binding of VPA is dependent on the plasma concentration.…”

Section: Disussionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma protein binding of valproic acid in healthy subjects and in patients with renal disease.

Gugler¹,

Muêller²

1978

Brit J Clinical Pharma

100

View full text Add to dashboard Cite

1 Based on the Scatchard plot of the binding data of valproic acid (VPA) it is concluded that the drug is bound by two groups of binding sites with the association constants K1=40.0 X 10(‐3) and K2=0.39 X 10(3), and the number of binding sites n1=1.5 and n2=6.8. 2 The binding is dependent on dialysis time, on temperature, on the drug concentration, and on the protein concentration in plasma. 3 At therapeutic plasma concentrations unbound VPA is 8.4 +/− 2.5%, but is increased to 20.3 +/− 4.7% in patients with significant impairment of renal function (P less than 0.001). 4 In patients with renal disease a good correlation is found between unbound VPA and serum creatinine, creatinine clearance, blood nitrogen and uric acid, respectively. A poor correlation is seen between unbound VPA and total protein or albumin concentration in plasma.

show abstract

Section: Introduction Methodsmentioning

confidence: 99%

Section: Disussionmentioning

confidence: 99%

Plasma protein binding of valproic acid in healthy subjects and in patients with renal disease.

Gugler¹,

Muêller²

1978

Brit J Clinical Pharma

100

View full text Add to dashboard Cite

show abstract

“…GABA plays an important role in depressed mood as its reduction in CSF was reported in depressed patients and elevated when these patients were treated with selective serotonin reuptake inhibitors. These findings may suggest a possible beneficial role of valproate in improving depressed mood [7,8]. However, in earlier studies, valproate was injected into the nucleus accumbens and its effect on GABAergic enzymes was controversial [9].…”

mentioning

confidence: 99%

Possible Anti-Anhedonic Effect of Valproate in Mice Exposed to Chronic Mild Stress model

El-Dine¹

2013

J Neurol Disord

View full text Add to dashboard Cite

Epilepsy is one of the most common neurological disorders characterized by recurring excessive neuronal discharge, exhibited by transient episodes of motor, sensory, or psychic dysfunction, with or without unconsciousness or convulsive movements. In addition epilepsy may be associated with neuro-degeneration presumably due to abnormal lipid per oxidation [1,2]. On the other hand, co-morbid depression is common in patients with epilepsy. A review of available studies [3] suggested a high prevalence of mood (affective) disorders especially major depression (8%-48%) followed by anxiety (5%-32%) in patients with epilepsy.Can the antiepileptic drug, sodium valproate induce beneficial effects on reduction in sucrose consumption and immobility in forced swimming test of stressed anhedonic albino mice. Additionally, can it has the ability to increase the activity of important anti-oxidant enzymes in hippocampus of these mice that would help in stopping the oxidative stress related to mood disorders.Actually, these effects could have a contributing role in control of convulsions in stressed mice according to literature [4]. Accordingly, these questions need an evaluation of sucrose consumption and duration of immobility after exposure to CMSmodel for 6 weeks and forced swimming test respectively in mice treated with the anti-epileptic drug sodium valproate (administered in the last 3 weeks of the model) and compare the results with that obtained from stressed untreated albino mice.Besides the above measured parameters, there is a strong need to measure the activities of the selected antioxidant enzymes catalase and glutathione peroxidase enzymes in hippocampus after 3-weeks of administration of the tested drug to the tested mice [5,6].However, valproate exerted an inhibitory effect on DA-induced hyperactivity similar to that produced by GABA. GABA plays an important role in depressed mood as its reduction in CSF was reported in depressed patients and elevated when these patients were treated with selective serotonin reuptake inhibitors. These findings may suggest a possible beneficial role of valproate in improving depressed mood [7,8]. However, in earlier studies, valproate was injected into the nucleus accumbens and its effect on GABAergic enzymes was controversial [9]. These results open the way to further investigations to reach a proper and well-defined conclusion.

show abstract

“…Valproic acid (VPA) is a major antiepileptic drug with efficacy against multiple seizure types ( Simon and Penry, 1975). Valproic acid is well known to affect mechanisms that control drug disposition, such as the activity of hepatic biotransformation enzymes or drug binding to plasma proteins (Rogiers et al, 1995;Wen et al, 2001;Perucca, 2006).…”

Section: Introductionmentioning

confidence: 99%

Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor

Takizawa

Kakizaki

Horiguchi³

et al. 2010

Drug Metabolism and Disposition

View full text Add to dashboard Cite

Sodium Di‐N‐Propylacetate (DPA) in the Treatment of Epilepsy:A Review

Cited by 249 publications

References 19 publications

Plasma protein binding of valproic acid in healthy subjects and in patients with renal disease.

Plasma protein binding of valproic acid in healthy subjects and in patients with renal disease.

Possible Anti-Anhedonic Effect of Valproate in Mice Exposed to Chronic Mild Stress model

Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor

Contact Info

Product

Resources

About