Sodium Ferulate Attenuates Lidocaine‐Induced Corneal Endothelial Impairment

Jiang, Guojian; Fan, Ting-Jun

doi:10.1155/2018/4967318

Cited by 12 publications

(4 citation statements)

References 51 publications

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“…All derivatives were characterized by high antioxidant activity, which was confirmed by other works on other FA derivatives. For example, it was found that sodium ferulate could protect human corneal endothelial cells from the oxidative damage induced by lidocaine, which causes corneal thickening, opacification, and corneal endothelial cell loss [ 51 ]. In another study a derivative of FA, hmy-paa (3-(4-hydroxy-3-methoxyphenyl)-N-(1H-pyrazol-3-yl) acrylamide), was demonstrated to selectively inhibit succinate dehydrogenase activity and efficiently abate myocardial cell injury caused by hypoxia [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

New Ferulic Acid and Amino Acid Derivatives with Increased Cosmeceutical and Pharmaceutical Potential

et al. 2022

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Ferulic acid (FA) has been widely used in the pharmaceutical and cosmetics industry due to its, inter alia, antioxidant, antiaging and anti-inflammatory effects This compound added to cosmetic preparations can protect skin because of its photoprotective activity. However, the usefulness of FA as a therapeutic agent is limited due to its low solubility and bioavailability. The paper presents the synthesis, identification, and physicochemical properties of new FA derivatives with propyl esters of three amino acids, glycine (GPr[FA]), L-leucine (LPr[FA]), and L-proline (PPr[FA]). The NMR and FTIR spectroscopy, DSC, and TG analysis were used as analytical methods. Moreover, water solubility of the new conjugates was compared with the parent acid. Both ferulic acid and its conjugates were introduced into hydrogel and emulsion, and the resulting formulations were evaluated for stability. Additionally, in vitro penetration of all studied compounds from both formulations and for comparative purposes using Franz diffusion cells was evaluated from the solution in 70% (v/v) ethanol. Finally, cytotoxicity against murine fibroblasts L929 was tested. All of the analyzed compounds permeated pig skin and accumulated in it. LPr[FA] and PPr[FA] were characterized by much better permeability compared to the parent ferulic acid. Additionally, it was shown that all the analyzed derivatives are characterized by high antioxidant activity and lack of cytotoxicity. Therefore, they can be considered as an interesting alternative to be applied in dermatologic and cosmetic preparations.

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Section: Discussionmentioning

confidence: 99%

New Ferulic Acid and Amino Acid Derivatives with Increased Cosmeceutical and Pharmaceutical Potential

et al. 2022

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“…Previous studies carried out on animal eyes determined that within six hours after death, the endothelium can be analysed without structural changes occurring in this layer (SIT et al, 2001;PIGATTO et al, 2005;PIGATTO et al, 2009;FAGANELLO et al, 2016). The use of slaughtered animal eyes for endothelial analysis has increasingly been shown to be an alternative to the use of live animals to assess the toxicity of intraocular drugs (PESCOSOLIDO et al, 2011;WEN et al, 2015;TERZARIOL et al, 2016;SILVA et al, 2018;JIANG et al, 2018). Corneal endothelial toxicity is related to substances that come into contact with the endothelium, based on their chemical compositions, pH and osmolarities (PARIKH & EDELHAUSER, 2003).…”

Section: Discussionmentioning

confidence: 99%

Acute effects of ropivacaine hydrochloride on corneal endothelial cell ultrastructure of horses: ex vivo study

et al. 2021

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The objective of this study was to evaluate the acute effects of ropivacaine hydrochloride on the corneal endothelium of horses. Forty-eight eyes were obtained from a commercial slaughterhouse and were randomly divided into three groups. In group A, the corneal endothelium was exposed to 0.75% ropivacaine hydrochloride for 60 seconds. In group B, the corneal endothelium was exposed to 0.75% ropivacaine hydrochloride for 15 minutes. In group C, the corneal endothelium was exposed to a balanced saline solution for 60 seconds. Afterwards, all samples were prepared for evaluation with scanning electron microscopy. Random electromicrographs were obtained from each sample. The images were analysed and, with the aid of software, areas with no endothelial cells were measured. The average endothelial loss, expressed as a percentage in relation to the total area, of the samples in group A was 5.28%. The average endothelial loss of samples from group B, expressed as a percentage in relation to the total area, was 20.39%. The damage to the corneal endothelium was significantly greater in group B compared to groups A and C. It was possible to conclude that 0.75% ropivacaine hydrochloride induced acute damage to corneal endothelium cells.

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“…Therefore, scavenging ROS is beneficial to inhibiting the exacerbation of UC. Sodium ferulic (SF), one of the active ingredients in traditional Chinese medicine, is believed to be a potent ROS scavenger. − According to previous studies, SF has shown promising potential in treating diseases such as neurodegenerative disorders, cardiovascular diseases, and cancer due to its powerful ROS-scavenging capacity. ,, However, the short in vivo half-life and low bioavailability restrict its further application . Incorporating SF into a CS-PDA hydrogel network can provide sufficient protection for SF and improve drug stability in vivo .…”

Section: Introductionmentioning

confidence: 99%

Injectable Bioadhesive Hydrogels Scavenging ROS and Restoring Mucosal Barrier for Enhanced Ulcerative Colitis Therapy

Li,

Chen

et al. 2023

ACS Appl. Mater. Interfaces

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Despite the progress in the therapy of ulcerative colitis (UC), long-lasting UC remission can hardly be achieved in the majority of UC patients. The key pathological characteristics of UC include an impaired mucosal barrier and local inflammatory infiltration. Thus, a two-pronged approach aiming at repairing damaged mucosal barrier and scavenging inflammatory mediators simultaneously might hold great potential for long-term remission of UC. A rectal formulation can directly offer preferential and effective drug delivery to inflamed colon. However, regular intestinal peristalsis and frequent diarrhea in UC might cause transient drug retention. Therefore, a bioadhesive hydrogel with strong interaction with intestinal mucosa might be preferable for rectal administration to prolong drug retention. Here, we designed a bioadhesive hydrogel formed by the cross-linking of sulfhydryl chondroitin sulfate and polydopamine (CS-PDA). The presence of PDA would ensure the mucosa-adhesive behavior, and the addition of CS in the hydrogel network was expected to achieve the restoration of the intestinal epithelial barrier. To scavenge the key player (excessive reactive oxygen species, ROS) in inflamed colon, sodium ferulic (SF), a potent ROS inhibitor, was incorporated into the CS-PDA hydrogel. After rectal administration, the SF-loaded CS-PDA hydrogel could adhere to the colonic mucosa to allow prolonged drug retention. Subsequently, sustained SF release could be achieved to persistently scavenge ROS in inflammatory areas. Meanwhile, the presence of CS would promote the restoration of the mucosal barrier. Ultimately, scavenging ROS and restoring the mucosal barrier could be simultaneously achieved via this SF-loaded bioadhesive hydrogel scaffold. Our two-pronged approach might provide new insight for effective UC treatment.

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Sodium Ferulate Attenuates Lidocaine‐Induced Corneal Endothelial Impairment

Cited by 12 publications

References 51 publications

New Ferulic Acid and Amino Acid Derivatives with Increased Cosmeceutical and Pharmaceutical Potential

New Ferulic Acid and Amino Acid Derivatives with Increased Cosmeceutical and Pharmaceutical Potential

Acute effects of ropivacaine hydrochloride on corneal endothelial cell ultrastructure of horses: ex vivo study

Injectable Bioadhesive Hydrogels Scavenging ROS and Restoring Mucosal Barrier for Enhanced Ulcerative Colitis Therapy

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