Sodium houttuyfonate inhibits inflammation by blocking the MAPKs/NF-κB signaling pathways in bovine endometrial epithelial cells

Sodium Houttuyfonate Alleviates Post-infarct Remodeling in Rats via AMP-Activated Protein Kinase Pathway

“…H. cordata is a classical Chinese herb used in traditional Chinese medicine for inflammatory diseases, such as pneumonia. Recently, SH, which was a pure compound extracted from H. cordata , has been found exerting anti-inflammatory and anti-fibrotic effects on animal and cell models of various diseases ( Gao et al, 2010 ; Du et al, 2012 ; Kang and Koppula, 2014a , 2015 ; Xu et al, 2015 ; Zhu et al, 2015 ; Wu et al, 2017 ). On LPS-induced bovine endometrial epithelial cell inflammation, SH treatment significantly decreased the expression of pro-inflammatory cytokines and alleviated the inflammatory process.…”

“…Sodium Houttuyfonate (SH), which was a pure compound extracted from a Chinese herb Houttuynia cordata , has shown potent anti-inflammatory and anti-fibrotic activities on various animal and cell models of diseases, like lipopolysaccharide (LPS)-induced acute lung injury (ALI), LPS-induced bovine endometrial epithelial cell inflammation, smoking-induced chronic obstructive pulmonary disease (COPD), ventricular remodeling induced by abdominal aortic banding and so on ( Gao et al, 2010 ; Du et al, 2012 ; Kang and Koppula, 2014a , 2015 ; Xu et al, 2015 ; Zhu et al, 2015 ; Wu et al, 2017 ). Based on these findings, we doubted whether SH with an inherent anti-inflammatory and anti-fibrotic potency, could ameliorate post-infarct cardiac remodeling and heart failure.…”

Palmatine inhibits TRIF-dependent NF-κB pathway against inflammation induced by LPS in goat endometrial epithelial cells

“…Collected gEECS after them were washed in phosphate-buffered saline (PBS, pH7. against β-actin to correct for differences in protein loading [22] . The result was analyzed using…”

Anti-tumor effect of volatile oil from Houttuynia cordata Thunb. on HepG2 cells and HepG2 tumor-bearing mice

“…Kim 51 et al reported that HCT disturbed the expression of Bcl-2 family proteins (Bax, Bcl-2, and Bcl-xL) and induced the apoptosis in human HepG2 hepatocellular carcinoma cells. Previous study shown that the activation of NF-kB was also intensely inhibited by volatile oil of HCT 33,46,52 NF-kappa B which plays a central role in tumor metastasis and angiogenesis 53,54 regulated the transcription of many cytokines. It has been reported that there was a high correlation between NF-kappa B and VGF expression.…”