Sodium Hyaluronate in the Treatment of Dry Eye Syndrome: A Systematic Review and Meta-Analysis

Ang, Bryan Chin Hou; Sng, James Jie; Wang, Priscilla Xin Hui; Htoon, Hla Myint; Tong, Louis

doi:10.1038/s41598-017-08534-5

Cited by 61 publications

(60 citation statements)

References 46 publications

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“…We also reviewed the latest published meta-analysis that focused on DED therapy. In summary, in comparison to AT or placebo, 0.05% cyclosporine group and omega-3 group had lower OSDI (MD = 4.10 and MD = 0.968), but carboxymethylcellulose group and sodium hyaluronate group had no statistical significance [20][21][22][23]. In consideration of the fact that AS group had significant lower OSDI (MD = 10.75) than AT group, AS might had powerful effectiveness in comforting DED patients.…”

Section: Discussionmentioning

confidence: 89%

Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2019

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Objective: To compare the efficacy of autologous serum (AS) eye drops and artificial tears (AT) in dry eye disease (DED). Methods: Five databases (PubMed, Science Direct, the Cochrane Library, the Chinese National Knowledge Infrastructure, and the Wanfang Database) were searched for randomized controlled trials (RCTs). Efficacy was evaluated in terms of the Ocular Surface Disease Index (OSDI), Schirmer I test, tear break-up time (TBUT), and fluorescein and rose bengal staining of ocular surface. The estimated effects of AS or AT were expressed as a proportion with the 95% confidence interval and plotted on a forest plot. Results: Seven RCTs with 267 subjects were included in the meta-analysis. For most of the studies, subjects' age was around 50 years old, and the mostly treatment duration was within 8 weeks. The followup results showed that the OSDI after AS treatment was lower than that after the AT treatment: the mean difference (MD) was-10.75 (95% CI,-18.12;-3.39) points. There was no difference on the Schirmer I test after treatment between the two groups: the MD was 1.68 (95% CI,-0.65; 4.00) mm. The TBUT of the AS group was longer than that of the AT group, with an MD of 4.53 (95% CI, 2.02; 7.05) s. There was no statistically significant difference on fluorescein staining score of the ocular surface between the AS group and the AT group, the MD was-2.53 (95% CI,-6.08; 1.03) points. The rose bengal staining score of the AS group was slightly lower than that of the AT group after treatment: the MD was-0.78 (95% CI,-1.34;-0.22) points. Conclusion: AS could be an effective treatment for DED, improving OSDI, TBUT, and rose bengal staining score. Further RCTs with large samples and longterm follow-up are still needed to determine the exact role of AS in the management of DED.

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Section: Discussionmentioning

confidence: 89%

Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2019

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“…The anti-inflammatory characteristics that have been attributed to GAGs and PGs, such as high molecular weight HA (HMWHA), makes them even more attractive candidates for use in treating dry eye. The number of studies using HA, chemically modified HA and HA analogs has increased exponentially over the past few years ( Salwowska et al, 2016 ; Ang et al, 2017 ; Pinto-Fraga et al, 2017 ). Lubricin is also emerging as a powerful agent in treating dry eye ( Lambiase et al, 2017 ; Regmi et al, 2017 ).…”

Section: Involvement Of Proteoglycans and Glycosaminoglycans In Cornementioning

confidence: 99%

Distribution and Function of Glycosaminoglycans and Proteoglycans in the Development, Homeostasis and Pathology of the Ocular Surface

Puri

Coulson-Thomas

Gesteira

et al. 2020

Front. Cell Dev. Biol.

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The ocular surface, which forms the interface between the eye and the external environment, includes the cornea, corneoscleral limbus, the conjunctiva and the accessory glands that produce the tear film. Glycosaminoglycans (GAGs) and proteoglycans (PGs) have been shown to play important roles in the development, hemostasis and pathology of the ocular surface. Herein we review the current literature related to the distribution and function of GAGs and PGs within the ocular surface, with focus on the cornea. The unique organization of ECM components within the cornea is essential for the maintenance of corneal transparency and function. Many studies have described the importance of GAGs within the epithelial and stromal compartment, while very few studies have analyzed the ECM of the endothelial layer. Importantly, GAGs have been shown to be essential for maintaining corneal homeostasis, epithelial cell differentiation and wound healing, and, more recently, a role has been suggested for the ECM in regulating limbal stem cells, corneal innervation, corneal inflammation, corneal angiogenesis and lymphangiogenesis. Reports have also associated genetic defects of the ECM to corneal pathologies. Thus, we also highlight the role of different GAGs and PGs in ocular surface homeostasis, as well as in pathology.

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“…HA is one of the main components of the extracellular matrix (ECM), and as such, is highly abundant in the ECM-rich tissues such as synovial fluid, vitreous body of eyes or dermis 16 , 17 . With a highly hydrophilic structure, HA plays important roles for water retention in skin and eyes 18 , 19 . In addition, the molecular weight of native HA being large (>1000KDa), the prepared solutions are generally very viscous with a shear-thinning character 20 .…”

Section: Introductionmentioning

confidence: 99%

Multivalent and multifunctional polysaccharide-based particles for controlled receptor recognition

Duan

Donovan

Foucher

et al. 2018

Sci Rep

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Polysaccharides represent a versatile class of building blocks that are used in macromolecular design. By choosing the appropriate saccharide block, various physico-chemical and biological properties can be introduced both at the level of the polymer chains and the resulting self-assembled nanostructures. Here, we synthetized amphiphilic diblock copolymers combining a hydrophobic and helical poly(γ-benzyl-L-glutamate) PBLG and two polysaccharides, namely hyaluronic acid (HA) and laminarin (LAM). The copolymers could self-assemble to form particles in water by nanoprecipitation. In addition, hybrid particles containing both HA and LAM in different ratios were obtained by co-nanoprecipitation of the two copolymers. By controlling the self-assembly process, five particle samples with different morphologies and compositions were developed. The interaction between the particles and biologically relevant proteins for HA and LAM, namely CD44 and Dectin-1 respectively, was evaluated by surface plasmon resonance (SPR). We demonstrated that the particle-protein interaction could be modulated by the particle structure and composition. It is therefore suggested that this method based on nanoprecipitation is a practical and versatile way to obtain particles with controllable interactions with proteins, hence with the appropriate biological properties for biomedical applications such as drug delivery.

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Sodium Hyaluronate in the Treatment of Dry Eye Syndrome: A Systematic Review and Meta-Analysis

Cited by 61 publications

References 46 publications

Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Autologous Serum Eye Drops versus Artificial Tear Drops for Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Distribution and Function of Glycosaminoglycans and Proteoglycans in the Development, Homeostasis and Pathology of the Ocular Surface

Multivalent and multifunctional polysaccharide-based particles for controlled receptor recognition

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