Sodium lauiyl sulphate damaged skin in vivo in man: a water barrier repair model

Zhai, Hongbo; Poblete, Nicholas; Maibach, Howard I.

doi:10.1111/j.1600-0846.1998.tb00081.x

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…In the present study, 2 models for barrier deterioration were used. One re¯ects irritant contact dermatitis, caused by exposure to an aqueous solution of a surfactant (21). In the other model TEWL is increased by mechanical removal of the outer layers of the stratum corneum by stripping the skin with adhesive tape.…”

Section: Discussionmentioning

confidence: 99%

“…Skin-identical lipids (SIL) (cholesterol, ceramide 3, oleic acid and palmitic acid) have also been incorporated in a cream base, and the aim of the present study was to compare the effect of this commercially available product on barrier recovery with that of pure petrolatum in disrupted human skin. The skin was damaged by an irritant (sodium lauryl sulphate, SLS) (17,21,22) and by mechanical removal of the outer stratum corneum by tape stripping (17,23,24). Barrier recovery and in¯ammation were instrumentally monitored for 14 days as transepidermal water loss (TEWL) and skin blood¯ow, using an Evaporimeter and a laser Doppler¯owmeter, respectively (21,24,25).…”

mentioning

confidence: 99%

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Skin-identical Lipids Versus Petrolatum in the Treatment of Tape-stripped and Detergent-perturbed Human Skin

Lodén

Bárány²

2000

Acta Dermato-Venereologica

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The cutaneous permeability barrier is localized to the stratum corneum interstices and is mediated by lamellar bilayers enriched in cholesterol, free fatty acids and ceramides. Topically applied lipids may interfere with the skin barrier function and formulations containing "skin-identical lipids" have been suggested to facilitate normalization of damaged skin. The aim of the present study was to compare the ability of "skin-identical lipids" in a petrolatum-rich cream base and pure petrolatum to facilitate barrier repair in detergent- and tape-stripped-perturbed human skin. Barrier recovery and inflammation were instrumentally monitored for 14 days as transepidermal water loss and skin blood flow, using an Evaporimeter and a laser Doppler flowmeter, respectively. Treatment with the 2 different products gave no indication that "skin-identical lipids" in a cream base are more efficient than pure petrolatum at promoting normalization in either of the 2 experimentally perturbed areas. This finding may support the hypothesis that different types of skin abnormality should be treated according to the underlying damage.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Skin-identical Lipids Versus Petrolatum in the Treatment of Tape-stripped and Detergent-perturbed Human Skin

Lodén

Bárány²

2000

Acta Dermato-Venereologica

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“…Several wound healing models have been developed (9)(10)(11)(12)(13)(14), which emphasize ICD rather than ACD. We utilized the nickel patch test to create a standardized ACD.…”

Section: Discussionmentioning

confidence: 99%

“…More effective topical agents are desired. Recently, several models have been developed in evaluating the efficacy of topical agents (9)(10)(11)(12)(13)(14); most studies have been performed in irritant contact dermatitis (ICD). The nickel-induced ACD model has had little use.…”

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confidence: 99%

In vivo nickel allergic contact dermatitis: human model for topical therapeutics

et al. 1999

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Techniques to determine efficacy of topical agents on allergic contact dermatitis (ACD) may benefit from refinement. The aim of this study was to develop an in vivo human model system for the bioengineering and visual quantification of the effect of topical agents on nickel ACD, and to correlate ACD parameters. 14 nickel patch-test-positive subjects were included in a placebo-controlled, double-blind study after a pre-screening procedure with a standard diagnostic patch test with nickel sulfate in 54 healthy human volunteers. 5% nickel sulfate in petrolatum in a Finn Chamber was applied on forearm skin for 48 h to create a standardized dermatitis. Thereafter, the dermatitis was treated with a model topical agent and a placebo control while recording endpoint parameters daily for 10 days. Resolution was quantified with 4 parameters: visual scoring (VS), transepidermal water loss (TEWL) (Tewameter), skin blood flow volume (BFV) (laser Doppler flowmeter), and skin color (a* value) (Colorimeter). The model agent reduced cutaneous allergic reactions, especially on day 8 to 10, in comparison with the placebo control. A highly significant linear relationship exists among all parameters, except between a* and BFV. This model may provide robust biometrics for determining the efficacy of topical therapeutics on experimentally induced ACD.

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Barrier Creams and Emollients

Zhai

Maibach

Irritant Dermatitis

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Sodium lauiyl sulphate damaged skin in vivo in man: a water barrier repair model

Abstract: This study suggests that topical agents may accelerate the repair rates of water barrier function in SLS-treated human skin. This model appears facile and robust for evaluating such repair.

Cited by 5 publications

References 33 publications

Skin-identical Lipids Versus Petrolatum in the Treatment of Tape-stripped and Detergent-perturbed Human Skin

Skin-identical Lipids Versus Petrolatum in the Treatment of Tape-stripped and Detergent-perturbed Human Skin

In vivo nickel allergic contact dermatitis: human model for topical therapeutics

Barrier Creams and Emollients

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