Sodium nitrite enhances generation of reactive oxygen species that decrease antioxidant power and inhibit plasma membrane redox system of human erythrocytes

Ansari, Firoz Ahmad; Mahmood, Riaz

doi:10.1002/cbin.10628

Cited by 23 publications

(16 citation statements)

References 42 publications

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“…Our study showed that NaNO 2 intoxication reduced antioxidant activity and increased both oxidative stress and lipid peroxidation in agreement with previous reports 11,30 . Antioxidant defenses are affected by the expression of genes such as thioredoxin, SOD, and GSH 46 , and oxidative stress is regulated by several other downstream genes, including HO-1 47 .…”

Section: Discussionsupporting

confidence: 94%

Hepatoprotective effect of Thymus vulgaris extract on sodium nitrite-induced changes in oxidative stress, antioxidant and inflammatory marker expression

Soliman

Aldhahrani

Metwally

2021

Sci Rep

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The herb thyme (Thymus vulgaris) has multiple therapeutic uses. In this study, we explored how T. vulgaris leaf extract protects liver cells against sodium nitrite-(NaNO2) induced oxidative stress. Mice were divided into four groups; each group received one of the following treatments orally: saline; T. vulgaris extract alone; NaNO2 alone; or T. vulgaris extract + NaNO2. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), IL-1β, IL-6, TNF-α, and total proteins were measured in serum using standard methods. TNF-α, hemooxygenase-1 (HO-1), thioredoxin, SOD, and GSH synthase, all of which are linked to oxidative stress, were measured using quantitative real-time PCR (qRT-PCR). In mice treated with T. vulgaris extract, the effect of NaNO2 on ALT and AST levels and total proteins was reduced, and its effect on antioxidant levels was reversed. Normally, NaNO2 causes hepatocyte congestion and severe hepatic central vein congestion. Tissues in the mice treated with T. vulgaris were restored to normal conditions. Our results demonstrate that NaNO2-induced hepatic injury is significantly reduced by pretreatment with T. vulgaris extract, which protects against hepatic oxidative stress and its associated genes at the biochemical, molecular, and cellular levels.

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Section: Discussionsupporting

confidence: 94%

Hepatoprotective effect of Thymus vulgaris extract on sodium nitrite-induced changes in oxidative stress, antioxidant and inflammatory marker expression

Soliman

Aldhahrani

Metwally

2021

Sci Rep

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“…This is suggesting that NaNO 2induced renal injury involves oxidative stress. This outcome is in tandem with other reports that NaNO 2 elicited oxidative lesion (Ansari & Mahmood, 2016;Ansari et al, 2017;Uslu et al, 2019).…”

Section: Ta B L Esupporting

confidence: 90%

Mechanism underlying nephroprotective property of curcumin against sodium nitrite‐induced nephrotoxicity in male Wistar rat

2020

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The use of sodium nitrite (NaNO) as preservative and fixative in meat and fish processing has gained tremendous attention in food industries (Hassan et al., 2009). It is responsible for the desirable red color (or shaded pink) of meat. In the medical industry, it is used mostly as muscle or bronchial dilator as well as a relaxant (Sun, Aoki, Wang, Guo, & Misumi, 2006), it is useful in relieving post hemorrhagic cerebral vasospasm (Fathi, Pluta, Bakhtian, Qi, & Lonser, 2011) and heart attack (Jones et al., 2013). The beneficial effect of NaNO2 has been reported to be achieved at the physiological concentration (McNally, Griffin, & Roberts, 2016). Despite all the beneficial effects of NaNO 2 , it was reported that exposure to its high concentration can trigger acute and chronic detrimental influence in several organs. For example, organ damage in rats following a single acute or chronic exposures to NaNO 2 at doses ranging from 20-75 mg/kg body weight has been

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“…Several in vivo and in vitro studies have reported nitrite toxicity mediated through oxidative stress [17,18]. This is supported by reports that antioxidants can ameliorate nitrite toxicity [19,20].…”

Section: Introductionmentioning

confidence: 81%

Acute oral dose of sodium nitrite induces redox imbalance, DNA damage, metabolic and histological changes in rat intestine

Ansari¹,

Ali²,

Arif³

et al. 2017

PLoS ONE

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Industrialization and unchecked use of nitrate/nitrite salts for various purposes has increased human exposure to high levels of sodium nitrite (NaNO2) which can act as a pro-oxidant and pro-carcinogen. Oral exposure makes the gastrointestinal tract particularly susceptible to nitrite toxicity. In this work, the effect of administration of a single acute oral dose of NaNO2 on rat intestine was studied. Animals were randomly divided into four groups and given single doses of 20, 40, 60 and 75 mg NaNO2/kg body weight. Untreated animals served as the control group. An NaNO2 dose-dependent decline in the activities of brush border membrane enzymes, increase in lipid peroxidation, protein oxidation, hydrogen peroxide levels and decreased thiol content was observed in all treated groups. The activities of various metabolic and antioxidant defense enzymes were also altered. NaNO2 induced a dose-dependent increase in DNA damage and DNA-protein crosslinking. Histopathological studies showed marked morphological damage in intestinal cells. The intestinal damage might be due to nitrite-induced oxidative stress, direct action of nitrite anion or chemical modification by reaction intermediates.

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Sodium nitrite enhances generation of reactive oxygen species that decrease antioxidant power and inhibit plasma membrane redox system of human erythrocytes

Cited by 23 publications

References 42 publications

Hepatoprotective effect of Thymus vulgaris extract on sodium nitrite-induced changes in oxidative stress, antioxidant and inflammatory marker expression

Hepatoprotective effect of Thymus vulgaris extract on sodium nitrite-induced changes in oxidative stress, antioxidant and inflammatory marker expression

Mechanism underlying nephroprotective property of curcumin against sodium nitrite‐induced nephrotoxicity in male Wistar rat

Acute oral dose of sodium nitrite induces redox imbalance, DNA damage, metabolic and histological changes in rat intestine

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