Sodium Tetrathionate and Methylene Blue in Cyanide and Carbon Monoxide Poisoning

Draize, John H.

doi:10.1126/science.78.2016.145

Cited by 14 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to its low toxicity and powerful penetration capacity, the thiazine cationic dye methylene blue is commonly used for lymph nodal vital staining. Furthermore, methylene blue is now represented as a new class of antioxidant drugs, and it is currently used in treating methemoglobinemia, cyanide and carbon monoxide poisoning, and some neurological diseases, with less side effects and low cost [ 6 , 7 , 22 ]. The effects of methylene blue in attenuating IR injury in several tissues or organs have been documented [ 23 – 27 ].…”

Section: Discussionmentioning

confidence: 99%

Methylene Blue Attenuates Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats

Wang

Chen

Lin

et al. 2018

Mediators of Inflammation

View full text Add to dashboard Cite

Objective This study was aimed to investigate the protective effect of methylene blue against lung injury induced by reperfusion of ischemic hindlimb in a rat model. Methods Twenty-four healthy adult male Sprague-Dawley rats were equally randomized into three groups: sham (SM) group, ischemia reperfusion (IR) group, and methylene blue (MB) group. Rats in both IR and MB groups were subjected to 4 h of ischemia by clamping the left femoral artery and then followed by 4 h of reperfusion. Treatment with 1% methylene blue (50 mg/kg) was administrated intraperitoneally at 10 min prior to reperfusion in the MB group. After 4 h of reperfusion, malondialdehyde (MDA) level, myeloperoxidase (MPO), and superoxide dismutase (SOD) activities in lung tissue were detected; inflammatory cytokines, including IL-1β and IL-6, were measured in bronchoalveolar lavage fluid (BALF); correspondingly, the morphological changes and water content in both gastrocnemius muscle and lung samples were evaluated. Results Hindlimb IR caused remarkable morphological abnormalities and edema in both muscle and lung tissues. SOD activity was decreased, both the MPO activity and MDA level in lung tissue, as well as IL-1β and IL-6 levels in BALF, were increased in the IR group (p < 0.05). Compared with the IR group, SOD activity was increased, whereas MPO activity and MDA level in lung tissue and IL-1β and IL-6 levels in BALF were decreased in the MB group (p < 0.05). Also, the histological damage and edema in both lung and muscle tissues were significantly attenuated by the treatment of methylene blue. Conclusion Methylene blue attenuates lung injury induced by hindlimb IR in rats, at least in part, by inhibiting oxidative stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Methylene Blue Attenuates Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats

Wang

Chen

Lin

et al. 2018

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…Therefore, seeking effective neuroprotective drugs is an immediate focus. MB is a lipophilic compound that has been used for the treatment of multiple disorders, including methemoglobinemia, malaria and cyanide poisoning (9,10,49). Recently, MB has been shown to play neuroprotective roles in a variety of mitochondria-associated cytotoxicity paradigms, such as stroke, Parkinson's disease, Alzheimer's disease, Huntington's disease and optic neuropathy (30,47).…”

Section: Discussionmentioning

confidence: 99%

“…MB readily crosses the blood-brain barrier and accumulates in the mitochondrial matrix (2,3); therefore, its biological functions primarily involve improving mitochondrial functions, such as enhancing cytochrome c oxidase activity (4), oxygen consumption (5,6) and ATP production (7) and reducing reactive oxygen species (ROS) generation (8). Clinically, MB has been approved by the FDA for methemoglobinemia and as an antidote to cyanide poisoning (9,10). A few studies have shown that MB reduces cerebral ischemia-reperfusion injury (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Methylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy

Yao

Zhao

et al. 2015

Mol Med

View full text Add to dashboard Cite

“…Methylene blue (MB) has been used with multiple therapeutical purposes in the treatment of malaria (Guttmann and Ehrlich, 1891;Adjalley et al, 2011;Krafts et al, 2012), carbon monoxide or cyanide poisoning (Draize, 1933), methemoglobinemia (Mansouri and Lurie, 1993), neurodegenerative diseases (Callaway et (Oliveira et al, 2011). MB is able to take electrons on its aromatic thiazine ring to be reduced to leucomethylene blue (MBH 2 ) and transfer electrons to other compounds depending on the redox states and the concentration of MB see (Rojas et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Enhanced hydrogen peroxide generation accompanies the beneficial bioenergetic effects of methylene blue in isolated brain mitochondria

Tretter

Horváth

Hölgyesi

et al. 2014

Free Radical Biology and Medicine

View full text Add to dashboard Cite

The redox dye methylene blue (MB) is proven to have beneficial effects in various models of neurodegenerative diseases. Here we investigated the effects of MB (100 nM, 300 nM, and 1 μM) on key bioenergetic parameters and on H2O2 production/elimination in isolated guinea pig brain mitochondria under normal as well as respiration-impaired conditions. As measured by high-resolution Oxygraph the rate of resting oxygen consumption was increased, but the ADP-stimulated respiration was unaffected by MB with any of the substrates (glutamate malate, succinate, or α-glycerophosphate) used for supporting mitochondrial respiration. In mitochondria treated with inhibitors of complex I or complex III MB moderately but significantly increased the rate of ATP production, restored ΔΨm, and increased the rate of Ca(2+) uptake. The effects of MB are consistent with transferring electrons from upstream components of the electron transport chain to cytochrome c, which is energetically favorable when the flow of electrons in the respiratory chain is compromised. On the other hand, MB significantly increased the production of H2O2 measured by Amplex UltraRed fluorimetry under all conditions, in resting, ATP-synthesizing, and respiration-impaired mitochondria, with each substrate combination supporting respiration. Furthermore, it also decreased the elimination of H2O2. Generation of H2O2 without superoxide formation, observed in the presence of MB, is interpreted as a result of reduction of molecular oxygen to H2O2 by the reduced MB. The elevated generation and impaired elimination of H2O2 should be considered for the overall oxidative state of mitochondria treated with MB.

show abstract

Sodium Tetrathionate and Methylene Blue in Cyanide and Carbon Monoxide Poisoning

Cited by 14 publications

References 0 publications

Methylene Blue Attenuates Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats

Methylene Blue Attenuates Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats

Methylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy

Enhanced hydrogen peroxide generation accompanies the beneficial bioenergetic effects of methylene blue in isolated brain mitochondria

Contact Info

Product

Resources

About