Sodium Transport and Essential Hypertension

Hilton, P. J.; Poston, Lucilla

doi:10.1016/s0140-6736(82)90079-4

Cited by 25 publications

(29 citation statements)

References 6 publications

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“…27,28 These discrepancies may be caused by differences in technique, 29 the type of population studied, inadequate sample size or the use of antihypertensive drugs. 30 In this study there was no difference in RBC Ki levels between never-treated hypertensives and those that were treated before the washout period. This is an important factor to take into consideration since some antihypertensive drugs affect K + homeostasis.…”

Section: Discussionmentioning

confidence: 48%

Red blood cell K+ could be a marker of K+ changes in other cells involved in blood pressure regulation

Delgado

Delgado-Almeida

2003

J Hum Hypertens

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The aim of this study is to determine whether red blood cell K + content (RBC Ki ) is associated with blood pressure levels and, if so, could RBC Ki be a marker of potassium changes in other cells involved in blood pressure regulation. The study was performed on 50 untreated hypertensives, 32 of their offspring and 50 age-and sex-matched controls. Systolic (SBP) and diastolic (DBP) blood pressures, height, weight, plasma, urine and red blood cell electrolytes were measured in all subjects. RBC Ki was significantly lower in hypertensives than in offspring of hypertensives and normotensive controls. Offspring of hypertensives had significantly lower RBC Ki than normotensive controls. Plasma K + was significantly lower both in hypertensives and offspring of hypertensives when compared to normotensive controls. A significant negative correlation was found in hypertensives between RBC Ki and DBP (r ¼ À0.27, P ¼ 0.04) and in offspring of hypertensives between RBC Ki and DBP (r ¼ À0.43, P ¼ 0.02). A significant correlation was found in hypertensives between RBC Ki and plasma K + (r ¼ 0.3, P ¼ 0.02). A positive correlation with borderline significance was found in hypertensives between RBC Ki and ionized Ca 2+ (r ¼ 0.2, P ¼ 0.1). In conclusion, our results support the hypothesis that RBC Ki is associated with blood pressure levels and that the measurement of RBC Ki levels may represent a biochemical marker for K + changes in other cells involved in blood pressure regulation. Further studies are necessary to explain the exact mechanisms of reduced RBC Ki levels in hypertensive patients and their offspring.

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Section: Discussionmentioning

confidence: 48%

Red blood cell K+ could be a marker of K+ changes in other cells involved in blood pressure regulation

Delgado

Delgado-Almeida

2003

J Hum Hypertens

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“…[91][92][93] Digitalis-like sodium transport inhibitors may be involved in the aetiology of the former, [94][95][96] especially in the presence of renal impairment. 97 It has recently been demonstrated that there is a reduction in Na/K ATPase pump sites (Bmax) in a group of children and adolescents with reflux nephropathy and a proposal has been made that a circulating ouabain-like inhibitor may be to blame contributing to the onset of hypertension.…”

Section: Sodium Transportmentioning

confidence: 99%

Reflux nephropathy and hypertension

Goonasekera

Dillon

1998

J Hum Hypertens

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Renal scarring associated with vesico-ureteric reflux (VUR), most commonly detected in young children, is associated with a significant risk of developing hypertension in later life. Hypertension in reflux nephropathy contributes significantly to morbidity including deterioration of renal function. The mechanism of onset of hypertension is not clear although abnormalities of the renin-angiotensin system and sodium/potassium ATPase activity have been described in some cases. It is becoming clear that radiologically detectable renal scars or small kidneys may histologically indicate a variety of diagnoses. Prediction of the risk of developing hypertension in individual cases is difficult and there-

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“…Numerous studies have reported abnormalities in erythrocyte sodium transport systems among hypertensive patients, but there has been considerable disagreement among investigators regarding abnormalities of intracellular sodium concentration and sodium pump activity. 2 Racial factors have also been reported to influence several sodium transport parameters in normotensive subjects.…”

Section: Erythrocyte Sodium Transport and Blood Pressure In White Submentioning

confidence: 99%

Erythrocyte sodium transport and blood pressure in white subjects.

et al. 1989

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The mechanisms that define the relation between blood pressure and sodium handling are not yet well understood. Although several abnormalities in sodium transport have been associated with hypertension, a link between the blood pressure of normotensive subjects and the erythrocyte sodium-potassium adenosine triphosphatase pump, the principal sodium transporter of sodium, has not been previously demonstrated. Data from independent measurements of erythrocyte intracellular sodium, ouabain-sensitive sodium efflux, and the number of sodium pump sites per red blood cell were used to calculate a second-order rate constant for ouabain-sensitive sodium efflux. Among 20 normotensive white subjects, this rate constant correlated significantly (p<0.005) with mean arterial blood pressure. A significant correlation was not observed between the rate constant and the blood pressure of 22 hypertensive subjects. A hypothesis is proposed, which suggests that the sodium efflux rate constant of erythrocytes is related to the control of sodium reabsorption via the sodium pump of the renal tubules and that an elevated erythrocyte rate constant may be associated with chronic increased sodium reabsorption, which leads to volume expansion and the development of hypertension. (Hypertension 1989;13:716-720)

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Sodium Transport and Essential Hypertension

Cited by 25 publications

References 6 publications

Red blood cell K+ could be a marker of K+ changes in other cells involved in blood pressure regulation

Red blood cell K+ could be a marker of K+ changes in other cells involved in blood pressure regulation

Reflux nephropathy and hypertension

Erythrocyte sodium transport and blood pressure in white subjects.

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