Sodium trimetaphosphate enhances the effect of 250 p.p.m. fluoride toothpaste against enamel demineralization in vitro

Missel, Emilene Macário Coimbra; Cunha, Robson Frederico; Vieira, A. E. M.; Cruz, Nathália V. S.; Castilho, F. C. N.; Delbem, Alberto Carlos Botazzo

doi:10.1111/eos.12277

Cited by 14 publications

(22 citation statements)

References 30 publications

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“…Despite the >4-fold difference in the F content between 250F-TMPnano and 1,100F, similar enamel F, Ca, and P concentrations were observed in enamel treated with these dentifrices. Such a trend is, indeed, in line with previous studies in which micrometric TMP was added to different low-F dentifrices (Takeshita et al 2009;Takeshita et al 2015;Missel et al 2016). The increased concentration of those Calcium 5.2E-02 a ± 2.0E-02 7.1E-02 a ± 3.9E-02 1.6E-01 b ± 7.7E-02 1.6E-01 b ± 8.6E-02 Phosphorus 1.5E-01 a ± 7.6E-02 1.2E-01 a ± 6.7E-02 1.8E-01 a ± 1.2E-01 1.8E-01 a ± 9.6E-02…”

Section: Discussionsupporting

confidence: 91%

“…Most important, while 250F-TMPnano and 1,100F dentifrices promoted similar SH values, the integrated subsurface hardness loss was significantly lower for 250F-TPMnano than for the conventional (1,100F) formulation. Because the addition of micrometric TMP to a 250F dentifrice was previously shown to produce a protective effect against enamel demineralization (SH and ΔKHN) similar to that of a conventional formulation (Missel et al 2016), the present ΔKHN findings seem to justify the use of nanoparticles instead of micrometric TMP. The more pronounced effect of nanosized TMP on ΔKHN suggests that, under clinical conditions, a subsurface lesion would take more time to develop as compared with a conventional dentifrice.…”

Section: Discussionmentioning

confidence: 65%

“…Such effects were further confirmed in a recent randomized controlled trial in which children brushing with a 500-ppm F toothpaste containing TMP developed significantly lower cavitated caries lesions when compared with those who used a toothpaste containing 1,100F (Freire et al 2016). Interestingly, a synergistic effect of F and TMP has also been demonstrated for dentifrices containing 250-ppm F (250F), which promoted a protective effect against enamel demineralization similar to that of a 1,100F, despite the >4-fold difference in F content in the formulations (Missel et al 2016).…”

Section: Introductionmentioning

confidence: 99%

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Toothpaste with Nanosized Trimetaphosphate Reduces Enamel Demineralization

Souza

Pessan

Lodi

et al. 2016

JDR Clinical & Translational Research

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This double-blind crossover study assessed the effects of a lowfluoride (low-F) dentifrice containing nanosized sodium trimetaphosphate (TMP) on enamel demineralization in situ. Nineteen subjects wore palatal appliances containing 4 blocks of bovine enamel and were randomly assigned to brush their teeth with placebo (without F/TMP), 250-ppm F (250F), 250F plus 0.05% nanosized TMP (250F-TMPnano), and 1,100ppm F (1,100F) dentifrices during 7 d, under cariogenic challenge. Enamel surface hardness and cross-sectional hardness (ΔKHN [Knoop hardness number]), as well as F, calcium (Ca), and phosphorus (P) concentrations, were determined. Also, biofilm that formed on the blocks was analyzed for F, Ca, P, and insoluble extracellular polysaccharide concentrations. Data were submitted to analysis-of-variance models and Student-Newman-Keuls test (P < 0.05). The 250F-TMPnano dentifrice promoted the lowest ΔKHN among all groups (P < 0.001), while the percentage of surface hardness loss was similar to 1,100F. Also, similar F, Ca, and P concentrations in enamel were observed for 1,100F and 250F-TMPnano. In the biofilm, the highest F content was observed for 1,100F; Ca content was similar between 1,100F and 250F-TMPnano; and P content was similar among all groups. Similar extracellular polysaccharide values were observed for 250F-TMPnano and 1,100F (P < 0.001), ionic activity of CaHPO 4 0 , CaF + , and HF 0 (P < 0.05) and degree of saturation of hydroxyapatite and CaF 2 (P < 0.05). It was concluded that the protective effect of 250F-TMPnano dentifrice was similar to a conventional dentifrice for most of the variables studied, having a more pronounced effect on the subsurface lesion when compared with the conventional toothpaste (1,100F). Knowledge Transfer Statement: Although toothpastes containing ≥1,000-ppm fluoride are more effective than low-fluoride formulations against dental caries, their early use can lead to side effects. This has prompted intensive research on alternatives to increase the anticaries effect of lowfluoride toothpastes. The present in situ study demonstrated that the addition of sodium trimetaphosphate nanoparticles to toothpastes containing 250-ppm fluoride significantly enhances the protective effect of this formulation against enamel demineralization to levels comparable to a 1,100-ppm fluoride toothpaste in terms of most of the variables studied. Most important, this formulation promoted the lowest loss of subsurface hardness among all groups, suggesting that caries lesions would take longer to develop under clinical conditions when compared with a conventional (1,100-fluoride) toothpaste.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Toothpaste with Nanosized Trimetaphosphate Reduces Enamel Demineralization

Souza

Pessan

Lodi

et al. 2016

JDR Clinical & Translational Research

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show abstract

“…It is reported that low-pH toothpastes containing 500 to 550 ppm fluoride showed similar results on enamel demineralization as the one containing 1100 ppm fluoride. 7 Dentifrice composition plays a crucial role in disabling free fluoride ions, which may lead to creation of a low-solubility product with a diminished anticaries outcome. 2,3 Currently, there are no regulations to specify how much of total fluoride should be maintained in a dentifrice formulation.…”

Section: Introductionmentioning

confidence: 99%

Comparative Fluoride Release and Antimicrobial Analysis of Commercial and Experimental Bioactive Glass/Nano-Oxide-Based Dentifrices

et al. 2020

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Objectives The objectives were to measure fluoride release and assess the antimicrobial behavior of fluoride-doped nano bioactive glass (F-nBG) and nano zinc oxide (ZnO)-enriched novel dentifrices. Materials and Methods Experimental dentifrices were synthesized by incorporating ZnO nanoparticles and F-nBG (1.5 wt% and 4 wt%) as active ingredients. The fluoride release behavior of suspensions and elutes of samples were analyzed by ion selective electrode. Antimicrobial activity and minimum bactericidal concentration against Streptococcus mutans and Lactobacillus casei were evaluated. Microbial stability against contamination was also assessed by a challenge test. Results The fluoride release behavior of experimental dentifrices was higher than that of commercial dentifrices and was dependent on filler loading. The fluoride release was more from suspensions than elutes. Zones of inhibition (ZOIs) and minimum bactericidal concentration values for novel dentifrices showed direct proportionality with filler loading, and effectiveness was exhibited against both strains. Experimental dentifrices exhibited effective antibacterial potential, which could possibly be due to release of sufficient fluoride and zinc ions in aqueous media from F-nBG and ZnO present in their formulations. Conclusion Combination of F-nBG and ZnO may provide a multi-benefit approach for simultaneously treating early white spot lesions, reducing bacterial growth, and providing core plaque control.

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“…Missel et al (14) demonstrated that the addition of phosphate in the form of sodium trimetaphosphate (TMP) to toothpaste containing (250ppm) fluoride can reduce enamel demineralization to levels similar to those seen for conventional toothpaste containing (1100ppmF) fluoride.…”

Section: Introductionmentioning

confidence: 99%

Remineralization Effect of Hexamet Aphosphate Combined With Low Fluoride Toothpaste on Enamel Surface of Primary Teeth

Nasr

Wahba

Bakry

2019

Alexandria Dental Journal

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INTRODUCTION: Investigators have been searching for alternative remineralizing compounds that have superior properties to those conventionally used; in order to reduce the risk of fluorosis in children. OBJECTIVES: To evaluate the anti-caries effect of hexametaphosphate (HMP) combined with low-fluoride toothpaste on primary teeth enamel surface using fluoride uptake analysis. MATERIALS AND METHODS: Seventy five freshly extracted anterior primary teeth were sectioned into two halves in a labiolingual direction (150 specimens). One half of each tooth remained untreated and served as control and the other corresponding half that was treated with the remineralizing toothpaste served as test. Specimens were assigned into subgroup IA (untreated) n=25, subgroup IB (250ppm F + 0.5% HMP) n=25, subgroup IIA (untreated) n=25, subgroup IIB (500 ppm F) n=25 and subgroup IIIA (untreated) n=25, subgroup IIIB (1000 ppm F) n=25. Specimens were subjected to pH cycling for five days and immersed in remineralizing solution for an additional two days. The enamel fluoride uptake analysis of specimens was evaluated quantitatively using an ion specific electrode. Data were analyzed using Mann-Whitney U, Kruskal-Wallis and Post-hoc pair-wise test. RESULTS: There was a significant high median enamel fluoride uptake between test subgroups IB (250ppm F + 0.5% HMP), IIIB (1000 ppm F) and their controls where p=0.008 and p=0.008 respectively, while there was no significant difference in median enamel fluoride uptake between the test subgroup IIB (500 ppm F) and its control subgroup IIA where p=0.690. Pairwise comparison of enamel fluoride uptake in the three test subgroups IB, IIB and IIIB showed significant high median value of subgroup IB than subgroup IIIB where p=0.027. CONCLUSIONS: A toothpaste containing 250ppm F + 0.5% HMP has a high anti-caries potential in comparison to pediatric 500 ppm F and standard 1000 ppm F toothpastes on primary teeth.

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Sodium trimetaphosphate enhances the effect of 250 p.p.m. fluoride toothpaste against enamel demineralization in vitro

Cited by 14 publications

References 30 publications

Toothpaste with Nanosized Trimetaphosphate Reduces Enamel Demineralization

Toothpaste with Nanosized Trimetaphosphate Reduces Enamel Demineralization

Comparative Fluoride Release and Antimicrobial Analysis of Commercial and Experimental Bioactive Glass/Nano-Oxide-Based Dentifrices

Remineralization Effect of Hexamet Aphosphate Combined With Low Fluoride Toothpaste on Enamel Surface of Primary Teeth

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