Sodium valproate does not augment Prpsc in murine neuroblastoma cells

Legendre, Christophe; Casagrande, Fabrice; Andrieu, Thibault; Dormont, D; Clayette, Pascal

doi:10.1007/bf03033916

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…However, administration of valproic acid to Chinese hamsters infected with prions did not cause any effects on the course of the disease (Shaked et al 2002 ). Other studies performed with cellular models did not confirm effects of valproic acid on the levels of PrP (Legendre et al 2007 ).…”

Section: Compounds Activating Autophagy and Their Therapeutic Potentimentioning

confidence: 88%

Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

et al. 2018

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Autophagy is a process of degradation of macromolecules in the cytoplasm, particularly proteins of a long half-life, as well as whole organelles, in eukaryotic cells. Lysosomes play crucial roles during this degradation. Autophagy is a phylogenetically old, and evolutionarily conserved phenomenon which occurs in all eukaryotic cells. It can be found in yeast Saccharomyces cerevisiae, insect Drosophila melanogaster, and mammals, including humans. Its high importance for cell physiology has been recognized, and in fact, dysfunctions causing impaired autophagy are associated with many severe disorders, including cancer and metabolic brain diseases. The types and molecular mechanisms of autophagy have been reviewed recently by others, and in this paper they will be summarized only briefly. Regulatory networks controlling the autophagy process are usually described as negative regulations. In contrast, here, we focus on different ways by which autophagy can be stimulated. In fact, activation of this process by different factors or processes can be considered as a therapeutic strategy in metabolic neurodegenerative diseases. These aspects are reviewed and discussed in this article.

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Section: Compounds Activating Autophagy and Their Therapeutic Potentimentioning

confidence: 88%

Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

et al. 2018

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Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases

Hirsch¹,

Martin-Lannerée²,

Reine³

et al. 2018

Mol Neurobiol

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Among the ever-growing number of self-replicating proteins involved in neurodegenerative diseases, the prion protein PrP remains the most infamous for its central role in transmissible spongiform encephalopathies (TSEs). In these diseases, pathogenic prions propagate through a seeding mechanism, where normal PrP molecules are converted into abnormally folded scrapie isoforms termed PrP. Since its discovery over 30 years ago, much advance has contributed to define the host-encoded cellular prion protein PrP as a critical relay of prion-induced neuronal cell demise. A current consensual view is that the conversion of PrP into PrP in neuronal cells diverts the former from its normal function with subsequent molecular alterations affecting synaptic plasticity. Here, we report that prion infection is associated with reduced expression of key effectors of the Notch pathway in vitro and in vivo, recapitulating changes fostered by the absence of PrP. We further show that both prion infection and PrP depletion promote drastic alterations in the expression of a defined set of Eph receptors and their ephrin ligands, which represent important players in synaptic function. Our data indicate that defects in the Notch and Eph axes can be mitigated in response to histone deacetylase inhibition in PrP-depleted as well as prion-infected cells. We thus conclude that infectious prions cause a loss-of-function phenotype with respect to Notch and Eph signaling and that these alterations are sustained by epigenetic mechanisms.

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In-vitro Neuro-2a cytotoxicity analysis and molecular docking investigation on potential anti-amyloid agents from Adiantum lunulatum

Jerom,

Jalal,

Sajan

et al. 2024

Heliyon

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Sodium valproate does not augment Prpsc in murine neuroblastoma cells

Cited by 3 publications

References 11 publications

Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases

In-vitro Neuro-2a cytotoxicity analysis and molecular docking investigation on potential anti-amyloid agents from Adiantum lunulatum

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