1982
DOI: 10.1111/j.1528-1157.1982.tb05085.x
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Sodium Valproate: Monotherapy and Polytherapy

Abstract: Of the 605 patients seen since 1973, 336 patients have been treated with sodium valproate (VPA) alone or in combination with drugs other than carbamazepine (CBZ). Of these 336, 240 have been on monotherapy, of whom 200 are seizure-free. Follow up has been longer than 3 years in 78%. Complete control of seizures has been achieved in more than 80% of patients with absence, myoclonic, and primary tonic-clonic seizures, in 72% of those with photosensitive epilepsy including eyelid myoclonia, and in 47% of partial … Show more

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Cited by 259 publications
(149 citation statements)
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References 42 publications
(29 reference statements)
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“…Sodium valproate (VPA), the sodium salt of 1982), which is now recognised as a first line valproic acid, is a broad spectrum anticonvulsant agent for the management of partial and generaldrug (Richens & Ahmed, 1975; al., ized seizures (Callaghan et al, 1985;Turnbull et 1979;Covanis et al, 1982;Callaghan et al, al., 1985). Its branched chain fatty acid structure Correspondence: Dr M. J.…”
Section: Introductionmentioning
confidence: 99%
“…Sodium valproate (VPA), the sodium salt of 1982), which is now recognised as a first line valproic acid, is a broad spectrum anticonvulsant agent for the management of partial and generaldrug (Richens & Ahmed, 1975; al., ized seizures (Callaghan et al, 1985;Turnbull et 1979;Covanis et al, 1982;Callaghan et al, al., 1985). Its branched chain fatty acid structure Correspondence: Dr M. J.…”
Section: Introductionmentioning
confidence: 99%
“…However, the controlled evidence for efficacy is mostly for juvenile myoclonic epilepsy [43,44]. Less impressive results are seen in other childhood myoclonic epilepsy syndromes [45]. Why is valproic acid seemingly more effective for cortical-subcortical myoclonus than levetiracetam, while the relative efficacy is reversed for cortical myoclonus?…”
Section: Cortical-subcortical Myoclonus Treatmentmentioning
confidence: 99%
“…En relación al ácido valproico, estudios no controlados describen que se obtiene un control de más del 50% de las crisis en: 55% de pacientes con drop attacks; 25-30% de pacientes con crisis de ausencia atípica y Mioclónicas; y menor tasa de respuesta para las crisis tónicas y tónico-clónicas (25,26). Sus principales efectos adversos son la hepatotoxicidad y la trombocitopenia que puede empeorar con la politerapia.…”
Section: Resultados De Ensayosunclassified