Soft coral-derived Aspernolide A suppressed non-small cell lung cancer induced osteolytic bone invasion via the c-Fos/NFATC1 signaling pathway

Jiao, Heng; Jiang, Wenli; Wang, Hongliang; Zheng, Hao; Yu, Hao‐Bing; Huang, Chun

doi:10.21037/jtd-21-1631

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…The marine environment is recognized as a rich source of numerous bioactive compounds that have been utilized as therapeutic agents in clinical settings, such as Cytarabine, Trabectedin, and Panobinostat ( Hao et al, 2019 ; Jiao et al, 2021 ). The discovery of marine compounds with potential antitumor properties offers a novel approach to cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

Sponge-derived alkaloid AP-7 as a sensitizer to cisplatin in the treatment of multidrug-resistant NSCLC via Chk1-dependent mechanisms

Guan,

Liao,

Cao

et al. 2024

Front. Pharmacol.

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Multidrug resistance is a substantial obstacle in treating non-small cell lung cancer (NSCLC) with therapies like cisplatin (DDP)-based adjuvant chemotherapy and EGFR-tyrosine kinase inhibitors (TKIs). Aaptamine-7 (AP-7), a benzonaphthyridine alkaloid extracted from Aaptos aaptos sponge, has been shown to exhibit a broad spectrum of anti-tumor activity. However, the anti-cancer activity of AP-7 in combination with DDP and its molecular mechanisms in multidrug-resistant NSCLC are not yet clear. Our research indicates that AP-7 bolsters the growth inhibition activity of DDP on multidrug-resistant NSCLC cells. AP-7 notably disrupts DDP-induced cell cycle arrest and amplifies DDP-induced DNA damage effects in these cells. Furthermore, the combination of AP-7 and DDP downregulates Chk1 activation, interrupts the DNA damage repair-dependent Chk1/CDK1 pathway, and helps to overcome drug resistance and boost apoptosis in multidrug-resistant NSCLC cells and a gefitinib-resistant xenograft mice model. In summary, AP-7 appears to enhance DDP-induced DNA damage by impeding the Chk1 signaling pathway in multidrug-resistant NSCLC, thereby augmenting growth inhibition, both in vitro and in vivo. These results indicate the potential use of AP-7 as a DDP sensitizer in the treatment of multidrug-resistant NSCLC.

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Section: Discussionmentioning

confidence: 99%

Sponge-derived alkaloid AP-7 as a sensitizer to cisplatin in the treatment of multidrug-resistant NSCLC via Chk1-dependent mechanisms

Guan,

Liao,

Cao

et al. 2024

Front. Pharmacol.

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“…In addition, we saw that, as the boundary structure in chorion at day 30, CG already possessed a unique gene expression network that is connected to the differentiation towards an invasive trophoblast part— eCG-secreting-endometrial cup cells. FOS and FOSL1 belong to the activating protein-1 (AP-1) transcription factor complex and are implicated in regulating gene networks controlling cellular invasion in diverse biological systems ( Jiao et al, 2021 ). FOS and FOSL1 exert opposing effects on trophoblast invasion and FOSL1 plays a positive role in human trophoblast cells ( Renaud et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

The transcriptome landscapes of allantochorion and vitelline-chorion in equine day 30 conceptus

Shen

Hong

Davshilt

et al. 2022

Front. Cell Dev. Biol.

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During equine early gestation, trophectoderm forms chorion tissue, which is composed of two parts that one is covering allantoin, called allantochorion (AC) and another is covering yolk sac, which here we call vitelline-chorion (VC). Given that little is known about the equine trophoblast-derived chorion differentiation at an early stage, we first compared the transcriptome of AC and VC of day 30 equine conceptus based on RNA-sequencing. As a result, we found that compared to VC, there are 484 DEGs, including 305 up- and 179 down-regulated genes in AC. GO and KEGG analysis indicated that up-regulated genes in AC are mainly cell proliferation and cell adhesion-related genes, participating in allantois expansion and allantochorionic-placenta formation; dominant genes in VC are extracellular exosome and other cell adhesion-related genes implicated in direct and indirect conceptus-maternal communication. Additionally, as for the progenitor chorion tissue of equine chorionic gonadotropin secreting endometrium cup—the chorionic girdle (CG), which locates at the junction of the dilating AC and regressing VC, we revealed its unique gene expression pattern and the gene regulation during its further differentiation in vitro. Collectively, this study sheds light on the molecular events regarding the trophoblast differentiation and function at an early stage of the equine preimplantation conceptus.

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Soft coral-derived Aspernolide A suppressed non-small cell lung cancer induced osteolytic bone invasion via the c-Fos/NFATC1 signaling pathway

Cited by 2 publications

References 41 publications

Sponge-derived alkaloid AP-7 as a sensitizer to cisplatin in the treatment of multidrug-resistant NSCLC via Chk1-dependent mechanisms

Sponge-derived alkaloid AP-7 as a sensitizer to cisplatin in the treatment of multidrug-resistant NSCLC via Chk1-dependent mechanisms

The transcriptome landscapes of allantochorion and vitelline-chorion in equine day 30 conceptus

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