Soft drinks and sweeteners intake: Possible contribution to the development of metabolic syndrome and cardiovascular diseases. Beneficial or detrimental action of alternative sweeteners?

Schiano, Concetta; Grimaldi, Vincenzo; Scognamiglio, Michele; Costa, Dário Alves da Silva; Soricelli, Andrea; Nicoletti, Giovanni Francesco; Napoli, Claudio

doi:10.1016/j.foodres.2021.110220

Cited by 33 publications

(17 citation statements)

References 155 publications

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“…The present study proves that the people who are not consumers of soft drinks are not obese and the ones who have regular soft drink intake are obese. These findings are like Schiano et al 15 who stated that soft drinks and sweeteners intake leads to an increase in the incidence of weight gain and obesity.…”

Section: Resultssupporting

confidence: 84%

Soft Drinks Intake is Associated with Obesity and Urine Disorders in Medical Students

Mughal¹,

Parveen²,

Faruqi³

et al. 2022

PJMHS

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Aim: To determine the ramifications of soft drinks on Body Mass Index and effects on various renal parameters. Study design: Cross-sectional study Place and duration of study: HBS Medical and Dental College from 1st January 2020 to 31st December 2021. Methodology: One hundred and ten students from first year to final year MBBS were recruited from Medical Colleges of Islamabad. We assessed caffeinated sugar beverage consumption (Sprite, Mountain Dew, Coke, Pepsi & 7-Up). Inclusion criteria consisted of users (n=48) who took caffeinated soft drinks at least 5-7 glasses/week. Those who took less than this drink was labelled non-users (n=62). Questionnaire we used was self-administered about sociodemographic data, height, weight, soft drinks consumption frequency, and a record of urine R/E Combi 10 strip test. Results: There were 41(37.3%) males and 69(62.7%) females. The percentage of underweight, normal, overweight and obese students was 31.8%, 36.4%, 22.7% and 9.1% respectively. Out of total females (62.7%), the group overweight (30.4%) and obese (10.1%) was highly significant. (p=0.008). The user students n=48(43.6%) took caffeinated drinks more than 5-7 glasses/week and were found to be significantly obese p=0.17 as compared to non-users n=62(56.4%).Soft drink consumption was significantly associated with proteins appearance in urine (p=0.00) and leucocytes (p=0.17) and the mean PH of urine of soda users was highly significantly acidic (p=0.00) by using combi-10 test strips. Conclusion: Very high sugar contents and other ingredients in soft drinks can be associated with obesity, metabolic and kidney disturbances in young students which in chronic cases exacerbate the condition. Keywords: Obesity, Urine disorder, Caffeinated drinks

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Section: Resultssupporting

confidence: 84%

Soft Drinks Intake is Associated with Obesity and Urine Disorders in Medical Students

Mughal¹,

Parveen²,

Faruqi³

et al. 2022

PJMHS

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“…Other underlying mechanisms could be causally involved. 92 93 Meta-analyses suggest associations between artificially sweetened beverages and metabolic syndrome, 94 95 a cardiometabolic risk factor defined by dyslipidaemia, abdominal obesity, high blood glucose, insulin resistance, and hypertension. 96 Artificially sweetened beverages were associated with increased risk of metabolic syndrome 89 90 97 in a cohort study, 97 a cross-sectional study, 89 and a multicentre randomised trial.…”

Section: Discussionmentioning

confidence: 99%

“…Other underlying mechanisms could be causally involved 9293. Meta-analyses suggest associations between artificially sweetened beverages and metabolic syndrome,9495 a cardiometabolic risk factor defined by dyslipidaemia, abdominal obesity, high blood glucose, insulin resistance, and hypertension 96.…”

Section: Discussionmentioning

confidence: 99%

Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort

Debras

Chazelas

Sellem

et al. 2022

BMJ

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Objectives To study the associations between artificial sweeteners from all dietary sources (beverages, but also table top sweeteners, dairy products, etc), overall and by molecule (aspartame, acesulfame potassium, and sucralose), and risk of cardiovascular diseases (overall, coronary heart disease, and cerebrovascular disease). Design Population based prospective cohort study (2009-21). Setting France, primary prevention research. Participants 103 388 participants of the web based NutriNet-Santé cohort (mean age 42.2±14.4, 79.8% female, 904 206 person years). Dietary intakes and consumption of artificial sweeteners were assessed by repeated 24 h dietary records, including brand names of industrial products. Main outcomes measures Associations between sweeteners (coded as a continuous variable, log10 transformed) and cardiovascular disease risk, assessed by multivariable adjusted Cox hazard models. Results Total artificial sweetener intake was associated with increased risk of cardiovascular diseases (1502 events, hazard ratio 1.09, 95% confidence interval 1.01 to 1.18, P=0.03); absolute incidence rate in higher consumers (above the sex specific median) and non-consumers was 346 and 314 per 100 000 person years, respectively. Artificial sweeteners were more particularly associated with cerebrovascular disease risk (777 events, 1.18, 1.06 to 1.31, P=0.002; incidence rates 195 and 150 per 100 000 person years in higher and non-consumers, respectively). Aspartame intake was associated with increased risk of cerebrovascular events (1.17, 1.03 to 1.33, P=0.02; incidence rates 186 and 151 per 100 000 person years in higher and non-consumers, respectively), and acesulfame potassium and sucralose were associated with increased coronary heart disease risk (730 events; acesulfame potassium: 1.40, 1.06 to 1.84, P=0.02; incidence rates 167 and 164; sucralose: 1.31, 1.00 to 1.71, P=0.05; incidence rates 271 and 161). Conclusions The findings from this large scale prospective cohort study suggest a potential direct association between higher artificial sweetener consumption (especially aspartame, acesulfame potassium, and sucralose) and increased cardiovascular disease risk. Artificial sweeteners are present in thousands of food and beverage brands worldwide, however they remain a controversial topic and are currently being re-evaluated by the European Food Safety Authority, the World Health Organization, and other health agencies. Trial registration ClinicalTrials.gov NCT03335644

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“…While artificial sweeteners and natural sweeteners are reported to have significant differences, epidemiological studies suggest that artificial sweeteners can promote cardiovascular diseases and increase risks for metabolic syndrome. In contrast, natural sweeteners could decrease hyperglycemia and enhance the metabolism of lipids [22]. Stevia rebaudiana, which belongs to an emerging resource of natural sweeteners, a review supported the positive effects of bioactive substances in stevia on fighting against cardiovascular diseases by lowering blood pressure, and it indicated it could normalize and regulate blood pressure [23].…”

Section: Cardiometabolic Conditionmentioning

confidence: 99%

Effects of sugar substitutes on health concerns and corresponding mechanisms related to gut microbiota

Fang

Wang

Ying

2023

Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022)

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Due to the worldwide epidemic of obesity and diabetes, it is recommended to reduce sugar consumption. Sweeteners are used widely as sugar substitutes since they duplicate the taste of normal sugar but have no or low calories. In addition to their supposed role in reducing caloric intake and controlling weight, a growing body of research disputing their effects on physical health. Some studies suggest artificial sweeteners may contribute to type 2 diabetes and obesity, and cardiovascular disease through several mechanisms such as insulin resistance and disrupting of gastrointestinal microflora. People should consider more intake of natural sweeteners as they take part in gene mutation and can be used by people with diabetes and the general population. However, artificial sweeteners, specifically aspartame, are probably linked to cancer risk. Although the carcinogenic mechanism has not been defined clearly yet, and further human-based studies should be done, there is a need for caution in the consumption of artificial sweeteners.

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Soft drinks and sweeteners intake: Possible contribution to the development of metabolic syndrome and cardiovascular diseases. Beneficial or detrimental action of alternative sweeteners?

Cited by 33 publications

References 155 publications

Soft Drinks Intake is Associated with Obesity and Urine Disorders in Medical Students

Soft Drinks Intake is Associated with Obesity and Urine Disorders in Medical Students

Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort

Effects of sugar substitutes on health concerns and corresponding mechanisms related to gut microbiota

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