Soft Tissue

Qian, Xiaohua

doi:10.1016/b978-1-4160-5329-3.00016-5

Cited by 7 publications

(2 citation statements)

References 155 publications

(216 reference statements)

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“…Pulmonary fibromatosis (PF) is a specific variant of fibromatosis, which is rarely reported in the literature as occurring in the lung. Like other classifications of fibromatosis, PF is a widespread, locally aggressive fibroblastic tumor that occasionally recurs but never metastasizes [ 5 ]. Here we report a case of PF with HIPK2-YAP1 fusion, the patient underwent thoracoscopic surgery and the resected specimen identified by histopathological, clinicopathological, immunohistochemical (IHC) and the genetics feature analysis.…”

Section: Introductionmentioning

confidence: 99%

A novel entity of HIPK2::YAP1 pulmonary fibromatosis

Liu,

Liang,

Chen

et al. 2024

BMC Pulm Med

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Background Pulmonary fibromatosis (PF) is a specific variant of fibromatosis, which is rarely reported occurring in the lung. PF with HIPK2-YAP1 fusion was a novel entity. Case presentation In this report, a 66-year-old male with PF had been smoking over 40 years. Multiple cords and small nodules in both lungs had been detected in a health examination two years earlier at our hospital. But approximately twofold enlarged in the lingual segment of the upper lobe in the left lung were disclosed in this year. Immunohistochemical analysis demonstrated that the vimentin and β-Catenin were positive in the largest nodule. After underwent a DNA/RNA panel next-generation sequencing (NGS), missense mutations and HIPK2-YAP1 fusion were found in this sample. Ultimately, the case diagnosis as PF with HIPK2-YAP1 fusion after multidisciplinary treatment. Currently, the patient is doing well and recurrence-free at 14 months post-surgery. Conclusions It’s difficult for patients with complex morphology to make accurate diagnosis solely based on morphology and immunohistochemistry. But molecular detection is an effective method for further determining pathological subtypes.

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Section: Introductionmentioning

confidence: 99%

A novel entity of HIPK2::YAP1 pulmonary fibromatosis

Liu,

Liang,

Chen

et al. 2024

BMC Pulm Med

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“…Cytologic evaluation begins by identifying the principal cytomorphologic pattern: adipocytic, myxoid, spindle cell, epithelioid, small round cell, and pleomorphic. 9 Cytogenetics is a useful adjunct to cytology FIGURE 1. Triaging cytology for cytogenetics is illustrated.…”

Section: Soft Tissue Tumorsmentioning

confidence: 99%