Abstract-The fourth industrial revolution, or industry 4.0, has recently become an important topic in the manufacturing context. This standard-based strategy integrates Smart Factories, Cyber-physical Systems, the Internet of Things, and the Internet of Service with the aim of extending the capacity of manufacturing systems. Although several authors have presented the advantages of this approach, few papers refer to an architecture that allows the correct implementation of industry 4.0 applications using the guidelines of the reference architecture model (RAMI 4.0). This article exposes the essential characteristics that allow a manufacturing system to be retrofitted to become an industry 4.0 application. Specifically, an intelligent manufacturing system based on a holonic approach was developed and implemented using standards like FDI, AutomationML and OPC UA according to the RAMI 4.0 model.3