Soils selenium level and esophageal cancer: An ecological study in a high risk area for esophageal cancer

Semnani, Shahryar; Roshandel, Gholamreza; Zendeh-Bad, A. S.; Keshtkar, Abbasali; Rahimzadeh, Hadi; Abdolahi, Nafiseh; Besharat, Sima; Moradi, Abdolvahab; Mirkarimi, Honeyehsadat; Hasheminasab, Seyedzinab

doi:10.1016/j.jtemb.2010.03.002

Cited by 28 publications

(21 citation statements)

References 31 publications

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“…In the present study, the level of Se in soil from high-risk areas for EC was significantly higher than in low-risk areas (P< 0.002). This suggests that Se level in soil could be a possible risk factor for EC in this area [11,15]. Consistent with previous studies, results of the present study indicated that contamination of the environment (soil, rice, etc.)…”

Section: Discussionsupporting

confidence: 92%

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Association of Heavy Metals and Selenium Content in Rice with Incidence of Esophageal Cancer in Golestan Province, Iran

Rahimzadeh¹,

Sadeghi²,

Beirami³

et al. 2017

jcbr

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Introduction: Heavy metals have an important role in human health because of their nutritive value and possible adverse effects. The objective of this study was to assess level of heavy metals and selenium in rice harvested in the Golestan Province, Iran. Materials and Methods: This study was conducted in the Golestan Province, northern Iran. The area under rice cultivation is 45714 acres. Overall, 69 rice samples were collected from rice farms in different areas of the province including high-risk (42 samples) and low-risk areas (27 samples) for esophagus cancer (EC). Concentrations of heavy metals were measured by polarograph. Voltammetric analysis was carried out using 797 VA computrace (Metrohm). Results: Maximum concentrations of zinc, cadmium, lead, copper, nickel, cobalt and selenium in high-risk areas for EC were 70.6, 0.41, 5.05, 14.4, 8.8, 0.88 and 0.48 mg/kg as dry weight, respectively. Maximum concentrations of these elements in the low-risk area for EC were 88.4, 0.37, 3.9, 17.2, 8.1, 0.27 and 0.25 mg/kg as dry weight, respectively. The concentration of Se in high-risk areas were significantly higher than that in low-risk areas (P<0.05). Conclusions: Heavy metals and Se may act as possible risk factors for EC in the Golestan Province, which should be considered when designing cancer control programs in this area.

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Section: Discussionsupporting

confidence: 92%

“…Golestan Province has been known as a high risk area for EC [13,14]. Se concentration in soil has been suggested as a possible risk factor for EC in the Golestan Province [15]. Se is a metalloid, present in nature and in organisms as organic and/or inorganic forms [16].…”

Section: Journal Of Clinical and Basic Research (Jcbr)mentioning

confidence: 99%

Association of Heavy Metals and Selenium Content in Rice with Incidence of Esophageal Cancer in Golestan Province, Iran

Rahimzadeh¹,

Sadeghi²,

Beirami³

et al. 2017

jcbr

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“…Therefore, additional environmental factors should be monitored to explore the sources of heavy metal pollutions to guarantee both arable soil quality and food safety. The high loadings of phosphorus indicate the increased elemental concentration because of the more frequent use of phosphorus fertilizers and organophosphate pesticides in the agricultural lands of Golestan province (33). In addition, spraying against pests in the cucumber fields at least twice a week may cause an increase in some heavy metals in vegetables.…”

Section: Discussionmentioning

confidence: 99%

Health Risk Assessment of Heavy Metals in Vegetables in an Endemic Esophageal Cancer Region in Iran

2018

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Background: Nowadays, the heavy metals pollution is increasing and the accumulation of these metals in food has posed adverse effects on humans such as inducing various kinds of cancer and non-cancer diseases. The Northeast of Iran, especially Torkman Sahra, has the maximum number of patients with esophageal cancer. Objectives: We investigated the levels of four heavy metals (Zn, Cd, Pb, and Cu) in cucumber and tomato samples in Golestan province, an endemic esophageal cancer region. We evaluated the levels and potential health risks of heavy metals in vegetable samples of Northeastern Iran. Methods: The heavy metal content of the samples was determined by polarography methods. All sample preparation and digestion procedures were carried out according to the Standard Methods for the Examination of Water and Wastewater, 20th Edition. Results:The results showed that Cd and Pb concentrations in cucumber and tomato were estimated to be respectively 2.4 to 14.4 and 1.6 to 7 folds higher whereas Zn and Cu levels were lower than the maximum permissible limit for vegetables. The amounts of Pb intake through the consumption of these vegetables were determined more than the provisional tolerable daily intake. The total non-cancer and cancer risk results indicated that the investigated region was relatively unsuitable for growing the vegetables in the view of the risk of the elevated intakes of heavy metals adversely affecting food safety for consumers. Pb was the heavy metal posing non-cancer risks while Cd caused the greatest cancer risk. Conclusions: It was concluded that due to the toxic effects of cadmium and lead, we should be more serious to reduce pollution levels in this region.

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“…The crude incidence rate and ASR, for men were 12.47 and 19.35, for women 5.80 and 8.60, in total 9.16 and 13.93 per 100,000 people in this region, respectively, that has been declined compared with previous years (Semnani et al, 2010), but was higher than average in Iran (Mousavi et al, 2009) and lower than average in the world, less developed areas, eastern Asia and central and eastern Europe (Jemal et al, 2011).…”

Section: Discussionmentioning

confidence: 77%

“…Along with dietary, lifestyle and environmental influential factors, soil selenium level (Semnani et al, 2010), high levels of pesticide used and exposure in Golestan province may have impact on high cancer incidence in this region (Heidari, 2003;Mohebbi et al, 2012). Regarding difference in gastric cancer incidence rate and its related factors in various populations, this study was designed for modeling the influential predictors on gastric cancer incidence in Golestan.…”

Section: Introductionmentioning

confidence: 99%

Modeling of Influential Predictors of Gastric Cancer Incidence Rates in Golestan Province, North Iran

Behnampour¹,

Hajizadeh²,

Zayeri³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Golestan province has a reputation for relatively high incidence rates of gastric cancer in Iran. Along with dietary, lifestyle and environmental influential factors, soil selenium and high levels of pesticide used may exert influence in this region. The present study was designed for modeling the influential predictors on incidence of gastric cancer in Golestan. All registered cases of gastric cancer from March 2009 to March 2010 (49 females and 107 males) were investigated. Data were gathered by both check list and researcher made questionnaire (demographic, clinical and lifestyle characteristics) and analysed using logistic regression. Mean (±SD) age at diagnosis was 62.9±13.8 years. CIR and ASR of gastric cancer showed 9.16 and 13.9 per 100,000 people, respectively. Based on univariate logistic regression, a history of smoking (OR= 2.076), unwashed hands after defecation (OR= 2.612), history of cancer in relatives (OR= 2.473), history of gastric cancer in first-degree relatives (OR= 2.278), numbers of gastric cancers in first-degree relatives (OR= 2.078), history of X-ray and dye exposure (OR= 2.395), history of CT scan encounter (OR= 2.915), improper food habits (OR= 3.320), specific eating behavior (OR= 0.740), consumption of probable high risk foods (OR= 2.942), charred flesh (OR= 1.945), and animal fat (OR= 2.716) were confirmed as a risk factors. Changes in lifestyle may be expected to increase gastric cancer incidence dramatically in the near future. Therefore, appropriate educational interventions should be designed and implemented by competent authorities

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Soils selenium level and esophageal cancer: An ecological study in a high risk area for esophageal cancer

Cited by 28 publications

References 31 publications

Association of Heavy Metals and Selenium Content in Rice with Incidence of Esophageal Cancer in Golestan Province, Iran

Association of Heavy Metals and Selenium Content in Rice with Incidence of Esophageal Cancer in Golestan Province, Iran

Health Risk Assessment of Heavy Metals in Vegetables in an Endemic Esophageal Cancer Region in Iran

Modeling of Influential Predictors of Gastric Cancer Incidence Rates in Golestan Province, North Iran

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