Sol-gel Chemistry in Medicinal Science

Coradin, Thibaud; Boissière, Michel; Livage, Jacques

doi:10.2174/092986706789803044

Cited by 113 publications

(73 citation statements)

References 132 publications

(166 reference statements)

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“…14 The process is based on inorganic polymerization in conditions compatible with biologicals, allowing the association of mineral phases with organic materials. The material is biodegradable in vivo and is subsequently secreted into urine.…”

Section: Introductionmentioning

confidence: 99%

Extended release of adenovirus from silica implants in vitro and in vivo

et al. 2008

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Despite promising preclinical results, the clinical benefits of cancer gene therapy have been modest heretofore. The main obstacle continues to be the level and persistence of gene delivery to sufficiently large areas of the tumor. One approach for overcoming this might entail extended local virus release. We studied the utility of silica gel monoliths for delivery of adenovirus to advanced orthotopic gastric and pancreatic cancer tumors. Initially, the biochemical properties of the silica-virus matrix were studied and nearly linear release as a function of time was detected. Virus stayed infective for weeks at +37 1C and months at +4 1C, which may facilitate storage and distribution. In vivo, extended release of functional replication deficient and also replication-competent, capsid-modified oncolytic viruses was seen. Treatment of mice with pancreatic cancer doubled their survival ( Po0.001). Also, silica gel-based delivery slowed the development of antiadenovirus antibodies.

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Section: Introductionmentioning

confidence: 99%

Extended release of adenovirus from silica implants in vitro and in vivo

et al. 2008

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“…20 The sol-gel technology is an excellent strategy to coat substrates with complex geometry under mild temperatures and low pressure; it employs liquid precursors. [20][21][22][23][24] Here, we studied how the properties of the ABS substrate obtained by AM changed after we coated the ABS polymer with silicon alkoxide and calcium ion by the sol-gel methodology. Sols with and without phosphate ion were prepared before the sol-gel process.…”

Section: Introductionmentioning

confidence: 99%

“…944 Acid catalysts produce dense networks, whereas alkali catalysts give porous xerogels. 20 The sol-gel technology is an excellent strategy to coat substrates with complex geometry under mild temperatures and low pressure; it employs liquid precursors. …”

mentioning

confidence: 99%

Calcium Phosphate Coatings by Sol-Gel on Acrylonitrile-butadiene-styrene Substrate

Bandeira¹,

Campos²,

Ciuffi³

et al. 2016

J. Braz. Chem. Soc.

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Additive manufacture is an effective technology to produce complex macrostructures from polymers. Sol-gel is a chemical process that affords multifunctional materials by functionalization of different substrates. This work reports on the use of acrylonitrile-butadiene-styrene polymer (ABS) as starting material to obtain a substrate by additive manufacture. Coating of ABS by the sol-gel methodology generated a multifunctional material. Sols with and without phosphate ions were prepared from silicon and calcium alkoxide. Based on X-ray diffraction patterns, a calcium phosphate crystalline structure emerged on ABS after contact of the substrate with simulated body fluid. Infrared analysis revealed that the peaks of the functionalized substrate shifted, indicating that ABS interacted with the sol-gel coating. According to thermal analysis, the maximum decomposition temperature of the coated samples was 20 °C higher as compared to non-coated ABS. Sol-gel and additive manufacture are important technologies to produce materials with applications in biological medium. Keywords: dip-coating, sol-gel, biomaterials IntroductionAdditive manufacture (AM, also known as rapid prototyping) assembles materials in the powder, filament, liquid, or slide form. The materials consist of successively stacked thin layers, resulting in a three-dimensional structure.AM uses computer-aided design (CAD) software to build a mould for the scaffold. The mould displays a branching network of shafts that will define the microchannels in the scaffold.1-5 The fusion deposition model (FDM) technique helps to structure the acrylonitrilebutadiene-styrene polymer (ABS), a mobile extruder head deposits layers of molten material. The layer-by-layer building approach produces highly complex structures that would be impossible to achieve with technologies based on material subtraction, the most frequently employed procedure nowadays. AM has important applications in several areas, including the aircraft and automobile industries, telecommunications, and medicine. [6][7][8] The sol-gel route is a chemical process that involves formation of a sol, namely a colloidal suspension of particles or molecules with liquid character and measuring between 1 and 1000 nm. The sol later goes through a gel phase, which consists of a colloidal system with solid character. In the gel phase, the molecules form a dispersed, continuous, branched, and interpenetrated structure in a system that is usually liquid. After solvent evaporation, the gel phase becomes a solid material that can be either a xerogel, if the solvent is removed by simple evaporation, or an aerogel, if the solvent is removed above its critical temperature and pressure. 9-12The sol-gel process is widely employed to prepare glasses and oxides and to modify surfaces. Sol-gel encompasses hydrolysis and condensation of metal alkoxides or semi-metallic precursors under mild conditions, to generate a polymer network. [13][14][15][16][17][18][19] Alkoxides can form homogeneous sols in various solvents and in the p...

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“…Com este fim, o processo sol-gel se mostra de grande valia para a confecção de revestimentos de materiais na odontologia e medicina, já que é capaz de produzir um revestimento de fácil obtenção, baixo custo, resistentes a diversos agressores e com propriedades de superfície diversas (CORADIN; BOISSIERE; LIVAGE, 2006;CHIRIAC et al, 2010).…”

Section: Discussionunclassified

“…Historicamente, o revestimento cerâmico de materiais orgânicos não era possível devido ao processamento da sílica ser através de temperaturas extremamente altas (CORADIN; BOISSIERE; LIVAGE, 2006). No entanto, com a tecnologia sol-gel este revestimento tornou-se possível, já que a deposição de sílica é obtida sem aumentos significativos da temperatura.…”

Section: Da Metodologiaunclassified

Estudo in vitro da formação do biofilme de Candida albicans em resina acrílica termopolimerizável revestida por nanopartículas de dióxido de silício (revestimento cerâmico)

Oliveira¹

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This study investigates an experimental coating (VIPI LTDA, Pirassununga, SP) by sol-gel process that modifies acrylic resin denture base with silicon dioxide nanoparticles (SNP) to decrease C. albicans biofilm growth. Therefore, it was first investigated the presence of sol-gel ceramic coating on polymethylmethacrylate (PMMA) by Fourier Transform Infrared Spectroscopy (FTIR). Then C. albicans biofilms were quantified by colony forming units (CFU/mL) and confocal scanning laser microscopy (CSLM). Fifty-one PMMA specimens were manufactured (10x10x3mm) and assigned to the experiments. To evaluate specimens' composition, it was analyzed three groups (n=1): CN-the specimen did not receive any surface treatment; CP-it was applied the coating primer on the specimen surface CL-the specimen was treated with the whole sol-gel process. In the following stage, 48 samples were divided into 3 groups (n=16) according to the polish type: PM3-3µm of roughness mechanical polish; PM03-0,3µm of roughness mechanical polish;PL-liquid polish. Samples of experimental group were coated according to manufacturer's instructions and all the samples were sterilized with ethylene oxide.After that, they were dipped in artificial saliva for 2hs to acquire the salivary pellicle, and then, dried and inoculated with 2 mL suspension of C.albicans (1.10 7 cel/mL) for 90 min. Then, specimens were washed and immersed in sterile RPMI solution (37⁰C for 12h). Half of the samples of each group (n=8) was assigned to each quantification test (UFC/mL and CSLM). By CSLM and software (BioImageL v.2) analysis was possible to obtain the total biovolume (µm and then by one way ANOVA followed by Tukey's test to assess difference between groups (p<0,05). FTIR results showed an adequate SNP deposition, allowing the quantification tests to be performed. UFC/mL and CLSM records showed similarity between PL and PM3 groups and difference when comparing these groups to smoother surfaces group (PM03). Therefore, in this study, the experimental coating was not effective to reduce colonization by C. albicans biofilm on PMMA surfaces.Nevertheless, further investigations are required since sol-gel ceramic coating process eases the features modification of the material, possibly leading to an ideal coating development.

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Sol-gel Chemistry in Medicinal Science

Cited by 113 publications

References 132 publications

Extended release of adenovirus from silica implants in vitro and in vivo

Extended release of adenovirus from silica implants in vitro and in vivo

Calcium Phosphate Coatings by Sol-Gel on Acrylonitrile-butadiene-styrene Substrate

Estudo in vitro da formação do biofilme de Candida albicans em resina acrílica termopolimerizável revestida por nanopartículas de dióxido de silício (revestimento cerâmico)

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