Sol-gel glass as a matrix for chemical and biochemical sensing

Lin, Jie; Brown, Chris W.

doi:10.1016/s0165-9936(97)00021-6

Cited by 269 publications

(196 citation statements)

References 62 publications

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“…The distribution, packing density and orientation of the attached probe may affect the performance of DNA biosensors. Several references review the design of DNA biosensors with aspect of transducer surface and probe immobilization [8,[116][117][118][119][120][121][122][123][124]. Immobilization methods vary depending on the kind of transducer surface and the application.…”

Section: Probe and Its Immobilizationmentioning

confidence: 99%

DNA Electrochemical Behaviors, Recognition and Sensing by Combining with PCR Technique

2003

Sensors

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Abstract:The electrochemical studies on the behaviors and recognition of DNA have attracted considerable attention. DNA biosensors based on nucleic acid hybridization process are rapidly being developed towards the goal of rapid and inexpensive diagnosis of genetic and infectious diseases. This brief review focuses on the current state of the DNA electrochemical sensors with emphasis on recent advances, challenges and trends. The works on DNA electrochemical behaviors, recognition and detection in our group in the last three years are also introduced.

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Section: Probe and Its Immobilizationmentioning

confidence: 99%

DNA Electrochemical Behaviors, Recognition and Sensing by Combining with PCR Technique

2003

Sensors

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“…Journal of the Ceramic Society of Japan 122 [2] 134-140 2014 JCS-Japan Japan). The surface area and pore diameter were measured using nitrogen (N 2 ) adsorption/desorption measurements in a TriStar 3000 system (Shimadzu Co., Kyoto, Japan).…”

Section: Characterizationmentioning

confidence: 99%

“…1), 2) This gel has found applications across many fields, such as optics, electronics, nanotechnology, medicine, biology, chemistry, materials science, and separation science. At the interface of biology, chemistry, and materials science, the immobilization of biomolecules via encapsulation within a solgel-derived matrix has been studied in recent years.…”

Section: Introductionmentioning

confidence: 99%

Preparation of silica hydrogels using a synthetic peptide for application as carriers for controlled drug release and mesoporous oxides

Kawachi¹,

Kugimiya²,

Kato³

2014

J. Ceram. Soc. Japan

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Solgel methods is a commonly used methods for encapsulation of enzyme and drug, but this method has two disadvantages of using acid or base as a catalyst and being difficult to control pore size of silica material. Even though synthesis under mild condition or silica with controlled pore size in the mesopore region have been reported, it is still difficult to achieve these two characteristics simultaneously. In this work, we chose 10-mer peptides of lysine (K), histidine (H), and block and alternate K and aspartic acid (D) as catalysts for silica mineralization, and silica gels were prepared using the synthetic peptides and a "leave to stand" synthesis method. The resulting silica hydrogels were lyophilized, and their surface areas and morphologies were characterized using the BrunauerEmmettTeller (BET) method and field-emission scanning electron microscopy (FE-SEM), respectively. Silica gels prepared by the "leave to stand" method with K 10 and H 10 exhibited a mesoporous structure with high surface area (576 and 451 m 2 g ¹1, respectively) and pore volume (0.35 and 0.30 cm 3 g ¹1 , respectively). SEM images confirmed the mesoporous structure of these gels. We encapsulated fluorescein sodium salt as a model drug within silica hydrogels using K 10 and H 10 as a catalyst. The silica hydrogel prepared using H 10 exhibited faster release of the drug (approximately 2.5-fold) than gels prepared using K 10 . These results demonstrate that by changing isoelectric point binding between the peptide and pore structure, the synthesized silica hydrogel-peptide composites can be designed to control the release rate of an encapsulated drug.

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“…Another way for bulk modification of electrode is using of carbon ceramic as matrix which can hold modifier and carbon nanotubes simultaneously. The carbon ceramic electrodes prepared by sol-gel techniques are interesting materials in the fields of electrochemical sensors and biosensors owing to their renewability, polishibility, chemical stability, physical rigidity, porosity, and permeability in electroanalysis (Lin & Brown, 1997).…”

Section: Carbon Nanotubes In Bulk Modificationmentioning

confidence: 99%