No abstract

In this paper, effect of NaHS, a hydrogen sulfide (H 2 S) donor on chlorophyll and antioxidant metabolism in seedling leaves of sweetpotato under osmotic stress was investigated. With the enhancement of osmotic stress, which was mimicked by PEG-6000, chlorophyll in seedling leaves of sweetpotato (Ipomoea batatas) decreased dramatically. At 15% PEG (w/v), chlorophyll concentration reached only 50% compared with that of the controls. The osmotic-induced decrease in chlorophyll concentration could be alleviated by spraying exogenous H 2 S donor, NaHS in a dose-dependent manner, while little visible symptoms were observed in leaves sprayed with NaHS under control conditions. It was also shown that H 2 S or HS -rather than other sulfur-containing components derived from NaHS contributed to the protective role against chlorophyll degradation during osmotic stress. Further studies showed that NaHS spraying dramatically promoted the activities of superoxide dismutase, catalase, ascorbate peroxidase and decreased that of lipoxygenase and the concentrations of hydrogen peroxide (H 2 O 2 ) and malondialdehyde. In addition, concentrations of endogenous H 2 S in NaHS-sprayed seedlings were higher than that in water-spraying control under osmotic stress. These data indicated that H 2 S plays a protective role in sweetpotato seedlings during osmotic stress.

Aim: CD147 and MMPs have been demonstrated to be involved in tumor invasion and angiogenesis. The aim of this study was to analyze the clinicopathological significance of CD147, MMP-1, MMP-2 and MMP-9 expression in human prostate cancer (PCa) and to evaluate their involvement in the progression of PCa. Methods: CD147, MMP-1, MMP-2 and MMP-9 expression was assessed in paraffin-embedded specimens collected from 62 cases of PCa and 15 cases of benign prostatic hyperplasia (BPH) by immunohistochemistry. Spearman’s correlation was applied to determine possible relationships between CD147, MMP-1, MMP-2 and MMP-9 expression and PCa. The association of CD147 and MMP-2 protein expression with the clinicopathological characteristics and the prognosis of PCa was subsequently assessed. Results: CD147was expressed in 51/62 (82.3%) PCa patients and in 2/15 (13.3%) BPH cases. MMP-1, MMP-2 and MMP-9 expression was significantly higher in PCa tissue than in BPH tissue. Using Spearman analysis, a significant positive correlation between CD147 and MMP-1, MMP-2 and MMP-9 expression was found (p <0.05). CD147 and MMP-2 expression was correlated with TMN grade and Gleason score. Patients with concurrent expression of CD147+ and MMP-2+ had the lowest survival (p <0.01). Conclusion: The results suggest that concurrent expression of CD147 and MMP may be an important characteristic of PCa which may help in the prediction of PCa progression.

No abstract

The expression of CD147 or VEGF may be an important feature of advanced RCC. A combined detection of CD147/VEGF coexpression may benefit us in the prediction of the prognosis of advanced RCC.