Sol-gel Titania-Coated Needles for Solid Phase Dynamic Extraction-GC/MS Analysis of Desomorphine and Desocodeine

Abstract

Novel sol-gel titania film coated needles for solid-phase dynamic extraction (SPDE)-GC/MS analysis of desomorphine and desocodeine are described. The high thermal stability of titania film permits efficient extraction and analysis of poorly volatile opiate drugs. The influences of sol-gel reaction time, coating layer, extraction and desorption time and temperature on the SPDE needle performance were investigated. The deuterium labeled internal standard was introduced either during the extraction of analyte or directly injected to GC after the extraction process. The latter method was shown to be more sensitive for the analysis of water and urine samples containing opiate drugs. The proposed conditions provided a wide linear range (from 5 -5000 ppb), and satisfactory linearity, with R 2 values from 0.9958 to 0.9999, and prominent sensitivity, LOQs (1.0 -5.0 ng/g). The sol-gel titania film coated needle with SPDE-GC/MS will be a promising technique for desomorphine and desocodeine analysis in urine.

DARK Classics in Chemical Neuroscience: Krokodil

“…Several studies on the validation of analytical methods for the detection of desomorphine in different samples have been published. Su et al developed a solid-phase dynamic extraction–gas chromatography–mass spectrometry (SPDE–GC–MS) method using sol–gel titanium film-coated needles for the detection and determination of desocodeine and desomorphine at trace levels in urine samples . SPDE is a modification of SPME that increases the sensitivity of the assay.…”

“…Su et al developed a solid-phase dynamic extraction− gas chromatography−mass spectrometry (SPDE−GC−MS) method using sol−gel titanium film-coated needles for the detection and determination of desocodeine and desomorphine at trace levels in urine samples. 101 SPDE is a modification of SPME that increases the sensitivity of the assay. This method showed a low limit of quantitation (LOQ) ranging from 1.0 to 5.0 ng/g for desocodeine and desomorphine, respectively.…”